Methods and compositions to inhibit dependence on opioids
The present invention provides a method of inhibiting dependence to an opioid by a human subject in need thereof. The method comprises administering an effective amount of a pharmaceutical composition to the subject during opioid therapy. The pharmaceutical composition comprises a) a non-steroidal anti-inflammatory drug (NSAID); and b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine, salts thereof and combinations thereof.
1. A method of inhibiting dependence to an opioid by a human subject in need thereof, comprising:
administering an effective amount of a pharmaceutical composition to the subject during opioid therapy,
wherein the pharmaceutical composition comprises:
a) a non-steroidal anti-inflammatory drug (NSAID); and
b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine, salts thereof and combinations thereof;
wherein dependence to an opioid is inhibited in the human subject.
2. The method of claim 1 wherein the NSAID is selected from the group consisting of: aspirin, ibuprofen, naproxen, diclofenac, diflunisal, etodolac, indomethacin, ketoprofen, ketorolac, meloxicam, nabumetone, oxaprozin, piroxicam, salsalate, sulindac, and tolmetin.
3. The method of claim 1 wherein the NSAID is ibuprofen and the co-agent is fexofenadine.
4. The method of claim 3 wherein the amount of ibuprofen is about 150 mg to about 900 mg, and the amount of fexofenadine is about 60 mg to about 180 mg.
5. The method of claim 3 wherein the composition is in the form of a tablet, lozenge or chewing gum.
6. The method of claim 2 wherein the NSAID is ibuprofen and the co-agent is ketotifen.
7. The method of claim 6 wherein the amount of ibuprofen is about 1200 mg to about 1600 mg, and the amount of ketotifen is about 0.5 mg to about 3 mg.
8. The method of claim 7 wherein a daily dose of about 2400 mg of ibuprofen and a daily dose of about 2 mg ketotifen are administered.
9. The method of claim 6 wherein the composition is in the form of a tablet, lozenge or chewing gum.
10. A method of inhibiting dependence to an opioid by a human subject in need thereof, comprising:
administering to the subject an effective amount of a pharmaceutical composition during an opioid therapy, wherein the pharmaceutical composition consists of active agents:
a) about 1200 mg to about 1600 mg of ibuprofen, and
b) about 0.5 mg to about 3 mg ketotifen,
wherein dependence to an opioid is inhibited in the human subject.
11. The method of claim 10 wherein a daily dose of about 2400 mg of ibuprofen and a daily dose of about 2 mg ketotifen are administered.
12. The method of claim 10 wherein the composition is in the form of a tablet, lozenge or chewing gum.