IP Library Granted Patent US 11,684,626
Granted Patent B2
US 11,684,626 · App. 17/233,455 · Granted Jun 27, 2023

Methods and compositions comprising ursolic acid and/or resveratrol for treating obesity, diabetes, or cancer

Inventors: Thomas J. Slaga (San Antonio, TX); Jacob Junco (San Antonio, TX); Huiyun Liang (San Antonio, TX); Sara Reyna (San Antonio, TX)
Assignee: Board of Regents, The University of Texas System
A61K31/56A61K9/0053A61K31/05A61K31/19A61P3/04A61P3/10
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Quick Facts
Patent No.
US 11,684,626
App. No.
17/233,455
Granted
Jun 27, 2023
Kind
B2
Abstract

Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.

Claims (24)

1. A method of decreasing inflammation in a human, the method comprising:

orally administering an effective amount of the nutritional supplement to decrease inflammation in the human, wherein the nutritional supplement is formulated to be orally administered one or mores time per day;

continuing the oral administration for multiple days; and

decreasing inflammation in the human;

wherein the nutritional supplement comprises ursolic acid and resveratrol in a ratio of ursolic acid to resveratrol of 3:1 to 1:3,

wherein the nutritional supplement is a tablet, a capsule, a concentrate, a powder, a drink, or a food, and

wherein the nutritional supplement is orally administered in addition to food in a normal diet.

2. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 50 to 600 mg of ursolic acid.

3. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 200 mg of ursolic acid.

4. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 50 to 600 mg resveratrol.

5. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 600 mg of resveratrol.

6. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 200 mg of ursolic acid and 600 mg of resveratrol.

7. The method of claim 1 , wherein the effective amount of the nutritional supplement comprises 100 mg of ursolic acid and 200 mg of resveratrol.

8. The method of claim 1 , wherein the nutritional supplement comprises one or more of a preserving, an emulsifying, or a dispersing agent.

9. The method of claim 1 , wherein the nutritional supplement comprises one or more of a filler or extender, a binder, a humectant, a disintegrating agent, solution retarder, absorption accelerator, wetting agent, an adsorbent, lubricant, or buffering agent.

10. The method of claim 9 , wherein the filler is starch, lactose, sucrose, mannitol, or silicic acid.

11. The method of claim 9 , wherein the binder is carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidone, sucrose, or acacia.

12. The method of claim 9 , wherein the humectant is glycerol.

13. The method of claim 9 , wherein the disintegrating agent is agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, complex silicates, or sodium carbonate.

14. The method of claim 9 , wherein the solution retarder is paraffin.

15. The method of claim 9 wherein the wetting agent is cetyl alcohol or glycerol monostearate.

16. The method of claim 9 , wherein the lubricant is talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, or mixtures thereof.

17. The method of claim 9 , wherein the nutritional supplement is a baked good, chocolate, caramel, cookie, or bar.

18. The method of claim 1 , wherein the nutritional supplement is a baked good, chocolate, caramel, cookie, or bar.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2021
From: SLAGA, THOMAS J; JUNCO, JACOB; LIANG, HUIYUN; REYNA, SARA
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 057318/0832 →
Continuity (6)
Continuation 16918378 · Jul 1, 2020
Continuation 16813017 · Mar 9, 2020
Continuation 16221094 · Dec 14, 2018
Continuation 15308427
Provisional Application 61988859 · May 5, 2014
Related Publication 20220023241A1 · Jan 27, 2022