Compositions and methods for the treatment of allergy
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
1 . A method of treating a food allergy, the method comprising orally administering to a subject in need thereof a therapeutically effective amount of a composition comprising:
(i) a purified bacterial strain belonging to the species Clostridium bolteae;
(ii) a purified bacterial strain belonging to the species Anaerotruncus colihominis;
(iii) a purified bacterial strain belonging to the species Sellimonas intestinalis or Drancourtella massiliensis;
(iv) a purified bacterial strain belonging to the species Clostridium symbiosum;
(v) a purified bacterial strain belonging to the species Blautia producta;
(vi) a purified bacterial strain belonging to the species Clostridium innocuum ; and
(vii) a purified bacterial strain belonging to the species Flavonifractor plautii.
2 . A method of treating a food allergy, the method comprising orally administering to a subject in need thereof a therapeutically effective amount of a composition comprising:
(i) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO: 1;
(ii) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO: 2;
(iii) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO: 3;
(iv) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO: 4;
(v) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO: 5;
(vi) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO: 7; and
(vii) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO: 8.
3 . The method of claim 2 , wherein:
the purified bacterial strain of (i) comprises a 16S rDNA sequence with at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 1;
the purified bacterial strain of (ii) comprises a 16S rDNA sequence with at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 2;
the purified bacterial strain of (iii) comprises a 16S rDNA sequence with at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 3;
the purified bacterial strain of (iv) comprises a 16S rDNA sequence with at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 4;
the purified bacterial strain of (v) comprises a 16S rDNA sequence with at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 5;
the purified bacterial strain of (vi) comprises a 16S rDNA sequence with at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 7; and
the purified bacterial strain of (vii) comprises a 16S rDNA sequence with at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 8.
4 . The method of claim 1 , wherein the composition does not comprise a purified bacterial strain belonging to the species Dorea longicatena.
5 . The method of claim 4 , wherein the composition does not comprise purified bacterial strains other than the purified bacterial strains of (i)-(vii).
6 . The method of claim 1 , wherein the food allergy is selected from the group consisting of a nut allergy, a fish allergy, a wheat allergy, a milk allergy, a peanut allergy, a tree nut allergy, a shellfish allergy, a soy allergy, a seed allergy, a sesame seed allergy, and an egg allergy.
7 . The method of claim 1 , wherein the food allergy is a peanut allergy.
8 . The method of claim 1 , further comprising administering a food allergen to the subject.
9 . The method of claim 1 , wherein the subject is a human.
10 . The method of claim 1 , further comprising administering an antibiotic to the subject prior to administering the composition.
11 . The method of claim 1 , wherein the composition is formulated for delivery to an intestine of the subject.
12 . The method of claim 3 , wherein the composition does not comprise a purified bacterial strain comprising a 16S rDNA sequence with at least 99% sequence identity to SEQ ID NO: 6.
13 . The method of claim 12 , wherein the composition does not comprise purified bacterial strains other than the purified bacterial strains of (i) (vii).
14 . The method of claim 3 , wherein the food allergy is selected from the group consisting of a nut allergy, a fish allergy, a wheat allergy, a milk allergy, a peanut allergy, a tree nut allergy, a shellfish allergy, a soy allergy, a seed allergy, a sesame seed allergy, and an egg allergy.
15 . The method of claim 3 , wherein the food allergy is a peanut allergy.
16 . The method of claim 3 , further comprising administering a food allergen to the subject.
17 . The method of claim 3 , wherein the subject is a human.
18 . The method of claim 3 , further comprising administering an antibiotic to the subject prior to administering the composition.
19 . The method of claim 3 , wherein the composition is formulated for delivery to an intestine of the subject.