Granted Patent
B2
US 11,814,396 · App. 17/246,775 · Granted Nov 14, 2023
Sesquiterpenoid analogs
Inventors:
Mingji Dai (Alpharetta, GA); Dexter Cameron Davis (Watertown, MA); Alexander Adibekian (Palm City, FL); Dominic Gregor Hoch (Jupiter, FL); Zhong-Yin Zhang (West Lafayette, IN)
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Abstract
The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.
Claims (2)
1. A compound of formula I:
2. The compound of claim 1 , wherein the compound is used as an SHP2 inhibitor for cancer treatments.
Assignments (4)
CONFIRMATORY LICENSE
Recorded May 20, 2024
From: PURDUE UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 067464/0790 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 5, 2023
From: ZHANG, ZHONG-YIN; DAI, MINGJI; DAVIS, DEXTER CAMERON
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 064156/0695 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 5, 2023
From: ADIBEKIAN, ALEXANDER; HOCH, DOMINIC GREGOR
To: THE SCRIPPS RESEARCH INSTITUTE
Reel/Frame 064156/0850 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 19, 2023
From: THE SCRIPPS RESEARCH INSTITUTE
To: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Reel/Frame 063696/0050 →
Continuity (4)
Provisional Application
62746126
· Oct 16, 2018
Provisional Application
62714785
· Aug 6, 2018