Granted Patent B2

US 12,420,084 · App. 17/247,179 · Granted Sep 23, 2025

Inventors: Conor Mulrooney (Manchester, GB); Veronika Matei-Rascu (Manchester, GB)

Assignee: Phagenesis Limited

A61N1/0517A61B5/037A61B5/6852A61J15/0003A61L29/04A61L29/041A61M25/0009A61M25/0041A61M39/10A61N1/0519A61N1/36007A61N1/3601

Abstract

Claims (30)

1. A catheter configured to be inserted along an insertion path into a gastrointestinal lumen of a patient, the insertion path including (a) a first curve between an external nares of the patient and a nasal cavity of the patient, and (b) a second curve between the nasal cavity and a nasopharynx of the patient, the catheter comprising:

a proximal portion, a distal portion, and a longitudinal axis extending between the proximal and distal portions, wherein the distal portion is configured to be positioned within the lumen of the patient during treatment;

a first portion having a first preset bend along the longitudinal axis corresponding to a shape of the first curve such that, when the catheter is removed from a storage container, the first portion assumes the first preset bend and is biased towards the first preset bend when positioned along the insertion path; and

a second portion having a second preset bend along the longitudinal axis corresponding to a shape of the second curve such that, when the catheter is removed from the storage container, the second portion assumes the second preset bend and is biased towards the second preset bend when positioned along the insertion path,

wherein, when the catheter is positioned along the insertion path, the first preset bend is positioned at the first curve and the second preset bend is positioned at the second curve.

2. The catheter of claim 1 , further comprising an electrode at the distal portion.

3. The catheter of claim 2 , wherein the electrode is configured to deliver stimulation energy to tissue proximate the lumen.

4. The catheter of claim 3 , wherein the stimulation energy is configured to treat dysphagia.

5. The catheter of claim 4 , wherein the distal portion is configured to be positioned in apposition with a posterior pharyngeal wall during treatment.

6. The catheter of claim 1 , wherein the distal portion is configured to be positioned in a pharynx of the patient.

7. The catheter of claim 1 , further comprising a lumen configured to slidably receive a feeding tube.

8. A device, comprising:

a treatment catheter having a preset shape such that sections of the catheter have varying radii of curvature based on the anatomical regions the catheter is configured to pass through, wherein the catheter has (a) a first portion with a first radius of curvature corresponding to a curve between an external nares and a nasal cavity of a patient, such that, wherein the catheter is removed from a storage container, the first portion assumes the first radius of curvature and is biased towards the first radius of curvature and (b) a second portion having a second radius of curvature corresponding to a curve between the nasal cavity and a nasopharynx of the patient, such that, when the catheter is removed from the storage container, the second portion assumes the second radius of curvature and is biased towards the second radius of curvature.

9. The device of claim 8 , further comprising an electrode at a distal portion of the catheter.

10. The device of claim 9 , wherein the electrode is configured to deliver stimulation energy to tissue proximate a lumen of the patient.

11. The device of claim 10 , wherein the stimulation energy is configured to treat dysphagia.

12. The device of claim 8 , wherein a distal portion of the catheter is configured to be positioned in a pharynx of the patient.

13. The device of claim 12 , wherein the distal portion is configured to be positioned in contact with a posterior pharyngeal wall during treatment.

14. The device of claim 8 , wherein the catheter further comprises a lumen configured to slidably receive a feeding tube.

15. A stimulation device configured to be nasally-inserted into a body of a patient, the device comprising:

an elongated shaft comprising:

a proximal portion configured to be extracorporeally positioned,

a distal portion configured to be positioned in contact with a pharyngeal wall at a treatment site, and

a region having a preset curvature based on a curvature of an anatomical transition between a nostril of the patient and a nasal cavity of the patient such that, when the elongated shaft is removed from a storage container, the region assumes the preset curvature and is biased towards the preset curvature when positioned in the anatomical transition between the nostril and the nasal cavity of the patient; and

an electrode at the distal portion of the shaft, the electrode configured to deliver stimulation energy to nerves proximate the treatment site to treat a pharyngeal disorder.

16. The stimulation device of claim 15 , wherein the distal portion is configured to be positioned in contact with a posterior pharyngeal wall during delivery of the stimulation energy.

17. The stimulation device of claim 15 , wherein the elongated shaft defines a lumen configured to slidably receive a feeding tube.

18. The stimulation device of claim 17 , wherein the feeding tube assumes the preset curvature of the region when positioned within the elongated shaft.

19. The stimulation device of claim 15 , wherein the region is a first region having a first preset curvature and the elongated shaft comprises a second region having a second preset curvature based on a curvature of an anatomical transition between the nasal cavity of the patient and a nasopharynx of the patient, wherein the second region assumes the second preset curvature and is biased towards the second preset curvature when removed from the storage container.

20. The stimulation device of claim 15 , wherein the elongated shaft has a flexible distal tip.

Assignments (1)

Priority Claims (1)

Continuity (3)

References Cited (225)

Cited By (1)

US 12,582,821