Devices, systems, and methods for treating disease using electrical stimulation
Electrical stimulation devices and associated systems and methods are disclosed herein. In some embodiments, the electrical stimulation device comprises an elongated member configured to be orally or nasally inserted into a patient's pharynx. The device may further include a conductive element carried by a distal portion of the elongated member and configured to deliver stimulation energy to nearby tissue. A stiffness of the elongated member may vary along its length to facilitate insertion of the elongated member through the nasopharyngeal junction and provide a restoring force necessary to hold the conductive element in apposition with tissue at the treatment site.
1 . A device comprising:
an elongated member for nasal insertion into a patient's pharynx, the elongated member having a proximal portion, a distal portion, and a longitudinal axis, wherein the elongated member comprises a first region having a first stiffness and a second region proximal of the first region along the longitudinal axis, and wherein the second region has a second stiffness less than the first stiffness; and
a conductive element carried by the distal portion of the elongated member and configured to be electrically coupled to an energy source for delivering electric current to nerves proximate the pharynx,
wherein, when the elongated member is inserted through a nostril of the patient such that the distal portion is positioned at a treatment site within the pharynx, the conductive element is placed in apposition with the pharyngeal wall, the first region extends along at least a portion of the nasal cavity and at least a portion of the nasopharynx, and the second region is positioned at or proximal of the patient's nostril.
2 . The device of claim 1 , wherein the elongated member further comprises a third region distal of the first region along the longitudinal axis of the elongated member, and wherein the third region has a stiffness different than the stiffness of the first region.
3 . The device of claim 1 , further comprising a distal element at the distal portion of the elongated member and positioned distal to the first region, wherein the distal element has a curved distal end portion configured to guide the distal portion of the elongated member around the nasopharynx and into the oropharynx during insertion of the device through the nasal cavity.
4 . The device of claim 1 , wherein the conductive element is positioned along the first region of the elongated member.
5 . The device of claim 1 , wherein a sidewall of the elongated member comprises a structural member coextensive with the first and second regions, wherein the structural member is at least one of a coil or a braid.
6 . The device of claim 1 , wherein the device further comprises a structural member disposed within a lumen of the elongated member, wherein the structural member is at least one of a coil or a braid.
7 . The device of claim 5 , wherein the structural member comprises a coil having a first length with a first pitch and a second length with a second pitch different than the first pitch.
8 . The device of claim 7 , wherein the first length of the coil is coextensive with the first region of the shaft and the second length of the coil is coextensive with the second region of the shaft.
9 . The device of claim 5 , wherein the structural member comprises a braid having a variable stiffness along its length.
10 . The device of claim 1 , wherein the first region of the elongated member is configured to be positioned proximal to an upper esophageal sphincter of the patient when the conductive element is delivering electric current to the nerves.
11 . The device of claim 1 , wherein the elongated member has a closed distal end.
12 . The device of claim 1 , wherein the electric current delivered to the nerves proximate the pharynx is configured to treat dysphagia.
13 . A device comprising:
an elongated member for nasal insertion into a patient's pharynx, the elongated member having a proximal portion, a distal portion, a biasing region between the proximal and distal portions, and a longitudinal axis, wherein the elongated member has a variable stiffness along the longitudinal axis; and
a conductive element carried by the distal portion of the elongated member and configured to be electrically coupled to an energy source for delivering electric current to nerves proximate the pharynx,
wherein the biasing region is biased towards a straight configuration such that, when the elongated member is inserted through a nostril of the patient and the biasing region bends around the nasopharyngeal junction, the elongated member applies a restoring force that holds the conductive element in contact with a posterior region of the pharyngeal wall.
14 . The device of claim 13 , wherein a stiffness of the elongated member along the biasing region is greater than a stiffness of a portion of the elongated member proximal of the biasing region.
15 . The device of claim 14 , wherein the portion of the elongated member is configured to be positioned at or proximal of the patient's nostril when the elongated member is positioned within the pharynx and delivering electric current.
16 . The device of claim 13 , further comprising a distal element at the distal portion of the elongated member and positioned distal to the second region, wherein the distal element has a curved distal end portion configured to guide the distal portion of the elongated member around the nasopharynx and into the oropharynx during insertion of the device through the nasal cavity.
17 . The device of claim 13 , wherein the conductive element is positioned along the biasing region of the elongated member.
18 . The device of claim 13 , wherein a sidewall of the elongated member comprises a structural member coextensive with the biasing region, wherein the structural member is at least one of a coil or a braid.
19 . The device of claim 13 , wherein the distal portion of the elongated member is configured to be positioned proximal to an upper esophageal sphincter of the patient when the conductive element is delivering electric current to the nerves.
20 . The device of claim 13 , wherein the elongated member has a closed distal end.
21 . The device of claim 13 , wherein the electric current delivered to the nerves proximate the pharynx is configured to improve a swallowing reflex of the patient.
22 . A method comprising:
inserting an elongated member through a nostril of a patient, the elongated member comprising a first region having a first stiffness and a second region having a second stiffness less than the first stiffness;
advancing the elongated member through the nasal cavity and into the pharynx such that a distal portion of the elongated member is positioned in the pharynx, wherein, when the distal portion is positioned in the pharynx, the first region spans a nasopharyngeal junction and the second region is positioned at or proximal of the patient's nostril; and
stimulating nerves proximate a treatment site via a conductive element carried by the distal portion of the elongated member.
23 . The method of claim 22 , further comprising urging the conductive element into contact with a posterior wall of the pharynx via a restoring force provided by the first region.
24 . The method of claim 22 , wherein the distal portion of the elongated member does not extend distally through the upper esophageal sphincter.
25 . The method of claim 22 , wherein stimulation of the nerves proximate the treatment site improves a swallowing reflex of the patient.