IP Library › Granted Patent US 12,252,708
Granted Patent B2
US 12,252,708 · App. 17/277,256 · Granted Mar 18, 2025

Living mammalian cells modified with functional modular nanoparticles

Inventors: Jimin Guo (Albuquerque, NM); C. Jeffrey Brinker (Albuquerque, NM); Wei Zhu (Albuquerque, NM); Jacob Ongudi Agola (Albuquerque, NM)
Assignee: UNM Rainforest Innovations
C12N5/0012C12N5/0602
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Quick Facts
Patent No.
US 12,252,708
App. No.
17/277,256
Granted
Mar 18, 2025
Kind
B2
Abstract

An encapsulated living (viable) mammalian cell, and methods of making and using that cell, are provided.

Claims (14)

1. An enveloped viable mammalian cell comprising:

a viable mammalian cell; and

a plurality of linked nanoparticles enveloping the cell,

wherein each of the nanoparticles has a diameter of 15 nm to 250 nm, and wherein the nanoparticles are linked via a metal-phenolic interaction, a boronic acid-phenolic acid interaction, or via a thiolated polyethylene glycol.

2. The enveloped mammalian cell of claim 1 wherein the cell is a human cell.

3. The enveloped mammalian cell of claim 1 wherein each of the nanoparticles has a diameter of 50 nm to 250 nm.

4. The enveloped mammalian cell of claim 1 wherein the nanoparticles are metal-organic nanoparticles.

5. The enveloped mammalian cell of claim 4 wherein the nanoparticles comprise Zn, Fe, Zr, Co or iron oxide.

6. The enveloped mammalian cell of claim 1 wherein the nanoparticles comprise silica.

7. The enveloped mammalian cell of claim 1 wherein the nanoparticles are functionalized with amine or phenol prior to linking.

8. The enveloped mammalian cell of claim 1 wherein the linkage is reversible.

9. The enveloped mammalian cell of claim 8 wherein the linkage is reversible with a metal chelator.

10. The mammalian cell of claim 1 wherein the linked nanoparticles are not permeable by a molecule having a diameter of about 5 nm or greater.

11. The enveloped mammalian cell of claim 1 wherein the linked nanoparticles are permeable by a molecule having a diameter of less than about 3 nm.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 10, 2024
From: BRINKER, C. JEFFREY; AGOLA, JACOB ONGUDI; ZHU, WEI; GUO, JIMIN
To: THE REGENTS OF THE UNIVERSITY OF NEW MEXICO
Reel/Frame 069542/0464 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 10, 2024
From: THE REGENTS OF THE UNIVERSITY OF NEW MEXICO
To: UNM RAINFOREST INNOVATIONS
Reel/Frame 069542/0574 →
CONFIRMATORY LICENSE Recorded Jan 9, 2024
From: UNIVERSITY OF NEW MEXICO
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 066241/0731 →
Continuity (2)
Provisional Application 62735585 · Sep 24, 2018
Related Publication 20220033768A1 · Feb 3, 2022
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