Granted Patent B2

US 12,498,379 · App. 17/282,976 · Granted Dec 16, 2025

Inventors: Eric Anslyn (Austin, TX); Edward Marcotte (Austin, TX); Cecil J. Howard, II (Austin, TX); Jagannath Swaminathan (Austin, TX); Angela M. Bardo (Austin, TX); Brendan M. Floyd (Austin, TX); James Reuther (Lowell, MA)

Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

G01N33/6824B01J20/0229B01J20/22C07K1/042C07K17/06C07K17/14C12Q1/6804

Abstract

Claims (13)

1 . A conjugating group selected from the group consisting of:

wherein the aromatic or heteroaromatic ring of the above formulas is optionally substituted with one or more functional groups, each independently selected from the group consisting of amino, cyano, halo, hydroxy, nitro, and a group of the formula: —[N(R a )(R b )(R c )]*, wherein R a , R b , and R c are each independently selected from the group consisting of hydrogen and optionally substituted C 1 -C 8 alkyl;

represents an attachment point to a solid support; and

R comprises a Rink linker and/or a polyethylene glycol linker.

2 . The conjugating group of claim 1 , wherein said solid support comprises a resin or a bead.

3 . The conjugating group of claim 1 , wherein R is coupled to an amine of said solid support.

4 . The conjugating group of claim 1 , wherein said conjugating group is configured to couple to an N-terminal amino acid of a peptide.

5 . The conjugating group of claim 4 , wherein said conjugating group is configured to reversibly couple to said N-terminal amino acid of said peptide.

6 . The conjugating group of claim 4 , wherein said conjugating group is configured to couple to said N-terminal amino acid of said peptide to generate a structure comprising:

wherein,

X 1 and Y 1 is the conjugating group;

R 1 is a side chain of an N-terminal amino acid of said peptide, and

R 2 comprises additional amino acids of said peptide.

Assignments (2)

Continuity (3)

References Cited (400)