Smart storage container for health logistics
Provided herein are methods and related devices for preprocessing a biological sample during transit. The method may comprise the steps of: storing a biological sample in a storage container having walls that defines a storage volume; transporting the storage container with the stored biological sample to a sample processing facility; controlling one or more storage container parameters during the transporting step to initiate preprocessing of the biological sample; wherein the controlling step improves a processing parameter at the sample processing facility.
1. A method of preprocessing a biological sample during transit, the method comprising the steps of:
storing a biological sample in a storage container having walls that define a storage volume;
transporting the storage container with the stored biological sample to a sample processing facility;
controlling one or more storage container parameters during the transporting step to initiate preprocessing of the biological sample;
wherein the controlling step improves a biological sample processing parameter at the sample processing facility;
wherein the one or more controlled storage container parameters is one or more of: temperature, reagent introduction, fixative introduction, centrifugation, mixing, washing, isolation, separation of one or more sample constituents, liquid manipulation, gas manipulation, or environmental control;
wherein the transporting step begins at a location different than the sample processing facility, such that the transporting step occurs in a separate location than the sample processing facility; and
wherein preprocessing refers to a processing of the sample during transit, that does not occur in the sample processing facility, such as chemical application, incubation, temperature cycling, physical separation or cell culturing,
and wherein the preprocessing results in a reduction of time required at the sample processing facility.
2. The method of claim 1 , wherein the improved biological sample processing parameter is one or more of:
a decrease in a number of processing steps at the sample processing facility;
a decrease in a processing time required at the sample processing facility upon delivery of the biological sample to the sample processing facility; or
an improved integrity of the sample processing outcome.
3. The method of claim 1 , further comprising the step of sensing a storage container parameter during the transporting step with one or more sensors.
4. The method of claim 1 , further comprising the step of collecting the biological sample, wherein the biological sample comprises a body fluid sample, a tissue sample, or an environmental sample.
5. The method of claim 1 , wherein the biological sample is used in an assay selected from the group consisting of: a radiological exposure assay; a cancer assay; a chemical assay; a biothreat exposure assay; a diagnostic assay; a molecular imaging assay; and a spectroscopic assay.
6. The method of claim 1 , further comprising the step of culturing cells in the biological sample during transport.
7. The method of claim 1 , wherein the controlled storage container parameters vary over time during the transporting step.
8. The method of claim 1 , wherein the storage container is vacuum-insulated comprising a plurality of sensors and actuators for controlling temperature in the storage container.
9. The method of claim 1 , wherein the storage container comprises:
a plurality of sensors selected from the group consisting of: a temperature sensor, an accelerometer; a position (GPS) sensor, a time sensor, a humidity sensor, a mechanical shock sensor, a tilt sensor, a radiation sensor, an optical sensor, a magnetic sensor, and any combinations thereof; and
a plurality of actuators selected from the group consisting of: a thermal actuator, a fluidic actuator, a mechanical actuator, an optical actuator, an electronic actuator, and any combinations thereof.
10. The method of claim 1 , wherein the storage container walls correspond to six surfaces, wherein a thermal actuator and a temperature sensor is connected to each surface, and a tethered temperature sensor is connected to the storage container to measure a container volume temperature or an external environmental temperature.
11. The method of claim 1 , wherein the storage container comprises temperature sensors and thermal actuators that provide a steady-state temperature control of between 1° C. and 100° C. with a steady state temperature deviation that is within ±0.5° C. of a selected steady-state temperature over the transporting step, including a user-selected time-varying steady-state temperature.
12. The method of claim 1 , wherein the storage container comprises an energy source, optionally a primary cell and/or a secondary cell, to provide power and control of the one or more storage container parameters for a time period that is greater than 0.25 hours and less than 7 days.
13. The method of claim 1 , wherein the storage container further comprises a wireless transmitter and a receiver for two-way communication with an external controller, the method further comprising the step of remotely controlling the one or more storage container parameters by sending from the external controller a control signal to the actuators.
14. The method of claim 1 , further comprising the step of recording a time course of system parameters, wherein the system parameters are selected from the group consisting of storage container location, storage container orientation, an impact force on the storage container, thermal actuator power level, temperature sensor reading, and any combinations thereof.
15. The method of claim 1 , wherein each of a plurality of thermal actuators are independently controlled to accommodate a spatially-varying thermal load over an external surface of the storage container.
16. The method of claim 1 , further comprising the step of automatically actuating thermal actuators to maintain the storage container volume within a user-specified temperature range.
17. The method of claim 1 , further comprising monitoring an operation parameter selected from the group consisting of: main battery voltage, power disconnect event due to impact, thermal actuator disabled due to battery depletion, and internal error.
18. The method of claim 1 , wherein the transporting step comprises transporting the storage container by an aerial drone.
19. The method of claim 1 , wherein the preprocessing comprises the addition of a reagent to the biological sample by a centrifugal system positioned in the storage volume.