Granted Patent
B2
US 12,350,045 · App. 17/302,835 · Granted Jul 8, 2025
Working electrode of a continuous biological sensor
Assignee:
Allez Health Inc.
A61B5/14865A61B5/14532C12N9/0006C12Q1/002C12Q1/006C25D7/0607C25D9/02G01N27/3271G01N27/3275H01M4/02H01M4/0402H01M4/0419H01M4/045H01M4/1395H01M4/1399H01M4/96A61B2562/125C12Y101/01027C12Y101/0103C12Y101/03004H01M2004/024
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Abstract
A working electrode for a subcutaneous sensor for use with a continuous biological monitor for a patient is disclosed. The working electrode includes a conductive substrate and an enzyme layer on the conductive substrate. The enzyme layer includes an enzyme, and the enzyme selected according to a biological function to be monitored. A hydrophobic material cross-linked with an acrylic polyol is included. The enzyme is fully entrapped in the cross-linked hydrophobic material with the acrylic polyol.
Claims (18)
1. A working electrode for a subcutaneous glucose sensor for use with a continuous glucose monitor for a patient, comprising:
a conductive substrate; and
an enzyme layer on the conductive substrate, the enzyme layer comprising:
glucose oxidase (GOx) enzyme;
a hydrophobic material cross-linked with a self cross-linking acrylic polyol; and
wherein the GOx enzyme is fully entrapped within the hydrophobic material cross-linked with the self cross-linking acrylic polyol.
2. The working electrode according to claim 1 , wherein the hydrophobic material is polyurethane.
3. The working electrode according to claim 1 , further comprising a glucose limiting layer over the enzyme layer, the glucose limiting layer limiting an amount of glucose from a patient's blood that passes to the enzyme layer.
4. The working electrode according to claim 3 , wherein the glucose limiting layer comprises a hydrophobic material that is physically cross linked to a hydrophilic material.
5. The working electrode according to claim 1 , wherein the enzyme layer further comprises:
a hydrophile comprised of polyvinylpyrrolidone (PVP); and
an additional cross-linker chosen from imidoesters, hydroxysuccinimide, carbodilite, melamines, epoxies, benzoyl peroxides or dicumyl peroxides.
6. The working electrode according to claim 1 , wherein the enzyme layer further comprises a hydrophile.
7. The working electrode according to claim 6 , wherein the hydrophile is polyvinylpyrrolidone (PVP).
8. The working electrode according to claim 1 , wherein the enzyme layer further comprises an imidoester, hydroxysuccinimide, carbodilite, melamine, epoxy, benzoyl peroxide or dicumyl peroxide.
9. The working electrode according to claim 1 , further comprising an interference layer between the enzyme layer and the conductive substrate.
10. The working electrode according to claim 1 , wherein the conductive substrate is a wire having a coating comprising platinum.
11. The working electrode according to claim 1 , wherein the conductive substrate is a wire having a coating comprising a carbon compound.
Assignments (2)
CHANGE OF NAME
Recorded May 17, 2024
From: ZENSE-LIFE INC.
To: ALLEZ HEALTH INC.
Reel/Frame 067456/0852 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 13, 2021
From: BOOCK, ROBERT JAMES; ZHANG, HUASHI
To: ZENSE-LIFE INC.
Reel/Frame 056235/0190 →
Continuity (5)
Provisional Application
62796842
· Jan 25, 2019
Provisional Application
62796832
· Jan 25, 2019
Provisional Application
62653821
· Apr 6, 2018
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