Granted Patent
B2
US 12,208,034 · App. 17/303,857 · Granted Jan 28, 2025
Implants with controlled drug delivery features and methods of using same
Inventors:
David S. Haffner (Mission Viejo, CA); Thomas W. Burns (Dana Point, CA); Harold A. Heitzmann (Irvine, CA); Kenneth M. Curry (Oceanside, CA)
Assignee:
Dose Medical Corporation
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Claims (22)
1. An implant for insertion into a punctum of an eye of a subject, comprising:
an outer shell having a proximal end, a distal end, and a side wall extending from the proximal end to the distal end, said side wall of the outer shell being shaped to define an interior space and being made of a first material,
the outer shell dimensioned for placement into the punctum of the eye of the subject;
at least a first drug positioned within said interior space; and
a cap at the proximal end of the outer shell and being made of a second material, different from the first material, wherein the second material is permeable or semi-permeable to at least the first drug and wherein the cap is positioned at least partially external to the outer shell;
wherein the first drug elutes from the implant to a tear film of an eye by passing through the cap.
2. The implant of claim 1 , wherein the second material is elastic or semi-elastic to allow the cap to be attached to the outer shell and retained in place at least in part by an elastic rebound of the second material.
3. The implant of claim 1 , wherein the implant is dimensioned to be implanted with the distal end of the outer shell positioned in a lacrimal duct or caniliculus.
4. The implant of claim 1 , wherein the implant is dimensioned to be implanted with the distal end of the outer shell positioned in a lacrimal sac.
5. The implant of claim 1 , wherein the implant is dimensioned to be implanted with the distal end of the outer shell positioned in a nasolacrimal duct.
6. The implant of claim 1 , wherein the cap comprises at least one aperture, further comprising at least one membrane that occludes said at least one aperture, wherein said membrane is permeable to the first drug, wherein said membrane allows elution of the first drug to occur only through the at least one membrane.
7. The implant of claim 1 , wherein the cap is dimensioned based on a permeability of the second material to the first drug and a desired duration of elution.
8. The implant of claim 1 , wherein the cap has a thickness of between about 50 and about 250 microns.
9. The implant of claim 1 , wherein further comprising a one-way valve allowing fluid flow from the interior space out the distal end of the implant.
10. The implant of claim 9 , wherein the one-way valve is configured to open in response to instilled fluid to allow flushing of the interior space to a nasolacrimal duct.
11. The implant of claim 9 , wherein the one-way valve is configured to remain closed until exposed to elevated pressure.
12. The implant of claim 1 , wherein the implant has a length of between about 0.5 and about 2.5 mm.
13. The implant of claim 1 , wherein the implant has a diameter of about 0.2 to about 1.5 mm.
14. The implant of claim 1 , wherein the first drug is a steroid.
15. The implant of claim 1 , wherein the first drug is for the treatment of dry eye.
16. The implant of claim 1 , wherein the first drug is an anti-glaucoma drug.
17. The implant of claim 1 , further comprising a sealing mechanism positioned between the cap and the outer shell, wherein the sealing mechanism comprises an o-ring.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 30, 2025
From: DOSE MEDICAL CORPORATION
To: GLAUKOS CORPORATION
Reel/Frame 070066/0322 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 16, 2024
From: HAFFNER, DAVID S.; BURNS, THOMAS W.; HEITZMANN, HAROLD A.; CURRY, KENNETH M.
To: DOSE MEDICAL CORPORATION
Reel/Frame 069594/0451 →
Continuity (4)
Continuation
14776666
Provisional Application
61788731
· Mar 15, 2013
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