IP Library › Granted Patent US 12,247,919
Granted Patent B2
US 12,247,919 · App. 17/360,667 · Granted Mar 11, 2025

Methods and systems utilizing optically-powered sensing integrated circuit(s) with optical information transfer

Inventors: Kenneth L. Shepard (Ossining, NY); Girish Ramakrishnan (New York, NY)
G01N21/6428A61B5/0031G02F1/025H01L31/02327A61B2560/0214G02F1/0157
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Quick Facts
Patent No.
US 12,247,919
App. No.
17/360,667
Granted
Mar 11, 2025
Kind
B2
Abstract

Systems and methods for performing non-destructive sensing of a cell or tissue, in vivo or in culture, are provided. The disclosed systems and methods include fabricating and powering one or more implantable integrated circuit (IC) chips that include a network of Photovoltaic (PV) cells for energy harvesting from an optical energy source, an optical modulator integrating Quantum Dot capacitors (QD-caps) for optical data transfer using fluorescence modulation, and sensing circuitry. The IC chip disclosed herein can measure a thickness of around 10 μm, allowing injection into small cells and diffusion through tissue, it is powered and imaged under a microscope and communicates using fluorescence modulation imaged under a microscope.

Claims (50)

1. A method for performing non-destructive sensing of a cell or a tissue, the method comprising:

implanting an integrated circuit into the cell or the tissue, wherein the integrated circuit comprises:

an energy harvestor configured to collect light from an optical source,

a sensor, coupled to the energy harvestor to be powered thereby, and configured to measure one or more signals associated with the cell or the tissue, and

at least one electro-optical modulator comprising a plurality of fluorescent materials and configured to receive the one or more signals and generate one or more optical signals;

receiving, by the integrated circuit, light transmitted by the optical source;

modulating the one or more signals with the transmitted light, by the optical modulator, to generate the one or more optical signals; and

transmitting the one or more optical signals, by the optical modulator.

2. The method of claim 1 , wherein the energy harvestor comprises one or more photovoltaic cells.

3. The method of claim 2 , wherein the one or more photovoltaic cells are comprised of one or more diodes.

4. The method of claim 1 , wherein the non-destructive sensing of the cell or the tissue is performed in vivo.

5. The method of claim 1 , wherein the one or more measured signals are electrical signals.

6. The method of claim 1 , wherein the one or more measured signals are electrochemical signals.

7. The method of claim 1 , wherein the integrated circuit is implanted into the cell or the tissue by injection.

8. The method of claim 1 , wherein modulating the transmitted light, by the optical modulator, comprises at least one of (i) modulating an intensity of the transmitted light, (ii) modulating a wavelength of the transmitted light, or (iii) modulating the intensity and wavelength of the transmitted light.

9. The method of claim 1 , wherein modulating the transmitted light is caused by the Quantum-confined Stark Effect exhibited by the plurality of the fluorescent materials.

10. The method of claim 1 , wherein the plurality of fluorescent materials form a capacitor comprising a layer of quantum dots.

11. The method of claim 1 , further comprising:

detecting the one or more optical signals, by an image sensor, wherein the image sensor is configured to measure and display the one or more optical signals.

12. The method of claim 1 , further comprising driving the at least one optical modulator by a relaxation oscillator.

13. The method of claim 1 , wherein the cell or the tissue is sensed in culture.

14. The method of claim 1 , wherein the at least one electro-optical modulator is coupled to the sensor.

15. A method for performing non-destructive sensing of a cell or a tissue, the method comprising:

implanting an integrated circuit into the cell or the tissue, wherein the integrated circuit comprises:

an energy harvestor configured to collect light from an optical source,

a sensor, coupled to the energy harvestor to be powered thereby, and configured to measure one or more signals associated with the cell or the tissue, and

at least one electro-optical modulator comprising a plurality of fluorescent materials and configured to receive the one or more signals and generate one or more optical signals;

receiving, by the integrated circuit, light transmitted by the optical source;

modulating the one or more signals with the transmitted light, by the optical modulator, to generate the one or more optical signals; and

transmitting the one or more optical signals, by the optical modulator, wherein the integrated circuit is implanted in the cell or the tissue by a microinjection or a micropipette from a solution or a dispersion in a solvent.

16. The method of claim 1 , wherein the integrated circuit is implanted into the cell by endocytosis.

17. The method of claim 16 , where endocytosis is facilitated by coating the integrated circuit with a biocompatible material associated with the cell.

18. The method of claim 15 , wherein the solvent is a deionized water.

19. A method for performing non-destructive sensing of a cell or a tissue, the method comprising:

implanting an integrated circuit into the cell or the tissue, wherein the integrated circuit comprises:

an energy harvestor configured to collect light from an optical source,

a sensor, coupled to the energy harvestor to be powered thereby, and configured to measure one or more signals associated with the cell or the tissue, and

at least one electro-optical modulator comprising a plurality of fluorescent materials and configured to receive the one or more signals and generate one or more optical signals;

receiving, by the integrated circuit, light transmitted by the optical source;

modulating the one or more signals with the transmitted light, by the optical modulator, to generate the one or more optical signals; and

transmitting the one or more optical signals, by the optical modulator, wherein modulating the transmitted light is caused by fluorescence quenching of the plurality of fluorescent materials.

20. A method for performing non-destructive sensing of a cell or a tissue, the method comprising:

implanting an integrated circuit into the cell or the tissue, wherein the integrated circuit comprises:

an energy harvestor configured to collect light from an optical source,

a sensor, coupled to the energy harvestor to be powered thereby, and configured to measure one or more signals associated with the cell or the tissue, and

at least one electro-optical modulator comprising a plurality of fluorescent materials and configured to receive the one or more signals and generate one or more optical signals;

receiving, by the integrated circuit, light transmitted by the optical source;

modulating the one or more signals with the transmitted light, by the optical modulator, to generate the one or more optical signals;

detecting the one or more optical signals, by an image sensor, wherein the image sensor is configured to measure and display the one or more optical signals, and wherein the optical source and the image sensor are integrated in a microscope; and

transmitting the one or more optical signals, by the optical modulator.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 9, 2025
From: SHEPARD, KENNETH L; RAMAKRISHNAN, GIRISH
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 073160/0671 →
GOVERNMENT INTEREST AGREEMENT Recorded Jun 6, 2025
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
Reel/Frame 071491/0088 →
Continuity (4)
Division 16041373 · Jul 20, 2018
Continuation PCTUS2017014569 · Jan 23, 2017
Provisional Application 62281566 · Jan 21, 2016
Related Publication 20210404963A1 · Dec 30, 2021
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