Radiopaque monomers, polymers, microspheres, and methods related thereto
Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
1. A method of embolization, comprising:
injecting an embolic composition into a blood vessel of a patient, the composition comprising:
a polymeric microsphere comprising a polymerized monomer having a structure according to Formula I:
wherein n is 0-12 and wherein R is either an oxygen-containing moiety or a nitrogen-containing moiety.
2. The method of claim 1 , wherein the monomer has a structure according to Formula Ia:
or a salt thereof.
3. The method of claim 1 , wherein the monomer has a structure according to Formula Ib:
or a salt thereof.
4. The method of claim 1 , wherein the polymeric microsphere is non-resorbable within a body of a patient.
5. The method of claim 1 , wherein the polymeric microsphere is radiopaque.
6. The method of claim 1 , wherein the composition comprises a plurality of polymeric microspheres.
7. The method of claim 1 , wherein the composition further comprises at least one of a cross-linker, a gelatin, or a coloring agent.
8. The method of claim 1 , wherein the composition further comprises an additional radiopaque agent.
9. The method of claim 1 , wherein the composition further comprises a magnetic agent.
10. The method of claim 1 , further comprising:
detecting a location of the polymeric microsphere more than about 24 hours, more than about 48 hours, more than about a week, or more than about a month after introduction of the polymeric microsphere.
11. A method of embolization, comprising:
injecting an embolic composition into a blood vessel of a patient, the composition comprising:
a polymeric microsphere comprising a polymerized monomer having a structure according to Formula I:
wherein n is 0-12 and wherein R is either an oxygen-containing moiety or a nitrogen-containing moiety;
wherein the polymeric microsphere is non-resorbable within a body of the patient,
wherein the polymeric microsphere is radiopaque, and
detecting a location of the polymeric microsphere more than about 24 hours, more than about 48 hours, more than about a week, or more than about a month after introduction of the polymeric microsphere structure.
12. The method of claim 11 , comprising:
detecting a location of the polymeric microsphere more than about a week, or more than about a month after introduction of the polymeric microsphere.
13. The method of claim 12 , wherein the composition comprises a plurality of polymeric microspheres .