(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.
1. A method of treating diabetic neuropathy, comprising administering to a human being an effective amount of a compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof, to treat the diabetic neuropathy.
2. The method of claim 1 , wherein the compound is
3. The method of claim 1 , wherein the compound is administered in the form of a tablet, pill, or capsule.
4. The method of claim 2 , wherein the compound is administered in the form of a tablet, pill, or capsule.
5. A method of treating neuropathic pain due to diabetic peripheral neuropathy, comprising administering to a human being an effective amount of a compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof, to treat the neuropathic pain due to diabetic peripheral neuropathy.
6. The method of claim 5 , wherein the compound is
7. The method of claim 5 , wherein the compound is administered in the form of a tablet, pill, or capsule.
8. The method of claim 6 , wherein the compound is administered in the form of a tablet, pill, or capsule.
9. A method of treating neuropathic pain due to diabetic neuropathy, comprising administering to a human being an effective amount of a compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof, to treat the neuropathic pain due to diabetic neuropathy.
10. The method of claim 9 , wherein the compound is
11. The method of claim 9 , wherein the compound is administered in the form of a tablet, pill, or capsule.
12. The method of claim 10 , wherein the compound is administered in the form of a tablet, pill, or capsule.
13. A method of treating nerve injury-induced neuropathic pain, comprising administering to a human being an effective amount of a compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof, to treat the nerve injury-induced neuropathic pain.
14. The method of claim 13 , wherein the compound is
15. The method of claim 13 , wherein the compound is administered in the form of a tablet, pill, or capsule.
16. The method of claim 14 , wherein the compound is administered in the form of a tablet, pill, or capsule.