Granted Patent
B2
US 12,515,186 · App. 17/455,313 · Granted Jan 6, 2026
Droplet assembly by 3D printing
Inventors:
John Hagan Pryce Bayley (Oxford, GB); Gabriel Villar (Oxford, GB); Alexander D. Graham (Oxford, GB)
Assignee:
OXFORD UNIVERSITY INNOVATION LIMITED
B01J13/04A61K9/127A61K9/1277B01L3/0268B29C64/112B29C69/00C09B57/001C09B67/0097B01L2300/0819B01L2400/0433B29K2105/0058B29L2031/753B33Y10/00B33Y30/00B33Y50/02B33Y80/00
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Abstract
The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises a droplet generator. A process for producing a droplet assembly, using an apparatus comprising a droplet generator is also described. The invention also relates to droplet assemblies comprising a plurality of droplets. Various uses of the droplet assemblies are also described.
Claims (12)
1 . A droplet assembly which comprises a plurality of droplets, wherein each of said droplets comprises (i) an aqueous medium, and (ii) an outer layer of amphipathic molecules around the surface of the aqueous medium, and wherein each of said droplets contacts another of said droplets to form a bilayer of said amphipathic molecules as an interface between the contacting droplets,
wherein the plurality of droplets comprises a first region of said droplets and a second region of said droplets, wherein each droplet in the first region contacts at least one other droplet in the first region to form a bilayer of said amphipathic molecules as an interface between the contacting droplets, and each droplet in the second region contacts at least one other droplet in the second region to form a bilayer of said amphipathic molecules as an interface between the contacting droplets,
wherein the aqueous medium of the droplets in the first region has a first osmolarity and the aqueous medium of the droplets in the second region has a second osmolarity, wherein the first osmolarity is different from the second osmolarity.
2 . The droplet assembly according to claim 1 , wherein the ratio of the first osmolarity to the second osmolarity is from 2:1 to 50:1.
3 . The droplet assembly according to claim 1 , wherein the aqueous medium of the droplets in the first region is an aqueous solution of a salt, which salt has a first concentration in the aqueous solution, and the aqueous medium of the droplets in the second region is an aqueous solution of the same salt, which salt has a second concentration in the aqueous solution, wherein the first concentration is different from the second concentration.
4 . The droplet assembly according to claim 3 , wherein the ratio of the first concentration to the second concentration is from 2:1 to 50:1.
5 . The droplet assembly according to claim 1 , wherein the droplets in the first region are arranged in a row, a plurality of rows, a layer or a plurality of layers, and the droplets in the second region are arranged in a row, a plurality of rows, a layer or a plurality of layers.
6 . The droplet assembly according to claim 1 , wherein the droplets in the first region are arranged in a layer or a plurality of layers, and the droplets in the second region are arranged in a layer or a plurality of layers, wherein droplets in the second layer or plurality of layers are disposed on or adjacent to droplets in the first layer or plurality of layers, so that droplets in the first layer contact droplets in the second layer to form bilayers of said amphipathic molecules as interfaces between the contacting droplets.
7 . The droplet assembly according to claim 6 , wherein the first and second layers or pluralities of layers comprise petal-shaped regions.
8 . The droplet assembly according to claim 7 , wherein the petal-shaped regions are capable of folding inwards and joining to form a hollow droplet assembly.
9 . The droplet assembly according to claim 2 , wherein the ratio of the osmolarity to the second osmolarity is from 5:1 to 20:1.
10 . The droplet assembly according to claim 4 , wherein the ratio of the first concentration to the second concentration is from 5:1 to 20:1.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 17, 2021
From: BAYLEY, JOHN HAGAN PRYCE; VILLAR, GABRIEL; GRAHAM, ALEXANDER D.
To: ISIS INNOVATION LIMITED
Reel/Frame 058417/0480 →
CHANGE OF NAME
Recorded Dec 17, 2021
From: ISIS INNOVATION LIMITED
To: OXFORD UNIVERSITY INNOVATION LIMITED
Reel/Frame 058417/0522 →
Priority Claims (1)
GB 1222052
· Dec 7, 2012
· national
Continuity (2)
Division
14649394
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