Compositions and method of use for hair straightening and shaping
Peptides are provided herein, wherein the peptide bearing one or more amino acid sequence differences relative to SEQ ID NO: 1, with the amino acid sequence differences comprising at least one cysteine replacement.
1. A peptide comprising substitution of at least one amino acid of SEQ ID NO:1 with a cysteine, wherein the peptide comprises at least 50% sequence identity to SEQ ID NO:1.
2. The peptide of claim 1 , wherein at least one cysteine substitution occurs at any one or more of a glutamine amino acid position, a valine amino acid position, an alanine amino acid position, and a serine amino acid position.
3. The peptide of claim 1 , wherein the peptide forms an alpha helix and at least one cysteine substitution is located on the outside region of the alpha helix.
4. The peptide of claim 1 , wherein one cysteine substitution is located in the region of SEQ ID NO: 1 consisting of SEQ ID NO: 2.
5. The peptide of claim 2 comprising a Q13C substitution relative to amino acid sequence of SEQ ID NO: 1.
6. The peptide of claim 2 comprising an H6C substitution relative to amino acid sequence of SEQ ID NO:1.
7. The peptide of claim 1 comprising a H6C substitution relative to the amino acid sequence of SEQ ID NO:1.
8. The peptide of claim 1 comprising an Q13C or H6C substitution and at least one additional cysteine substitution at any other amino acid position relative to SEQ ID NO 1.
9. The peptide of claim 8 , wherein the at least one additional cysteine substitution is ≥1 and ≤11 amino acids relative to SEQ ID NO: 1.
10. The peptide of claim 1 comprising substitution of at least 3 amino acids of SEQ ID NO: 1 with cysteine.
11. The peptide of claim 10 , wherein the at least one cysteine substitution is ≥3 and ≤11 amino acids relative to SEQ ID NO: 1.
12. The peptide of claim 1 comprising the amino acid sequence of any one of SEQ ID NOS:3-109, or a variant thereof with at least 70% sequence identity thereto.
13. The peptide of claim 1 , wherein the peptide has the amino acid sequence of SEQ ID NO: 8 or a variant thereof with at least 70% sequence identity thereto.
14. A hair composition comprising a plurality of the peptide of claim 1 .
15. The composition of claim 14 comprising about 0.001% to about 25%, about 0.001% to about 20%, about 0.001% to about 15%, about 0.001% to about 10%, about 0.001% to about 5%, about 0.001% to about 1%, or about 0.01 to about 0.1% wt/wt of the peptide to the total weight of the hair composition.
16. A kit comprising the peptide of claim 12 .