System and process for purification of Astatine-211 from target materials
A new column-based purification system and approach are described for rapid separation and purification of the alpha-emitting therapeutic radioisotope 211 At from dissolved cyclotron targets that provide highly reproducible product results with excellent 211 At species distributions and high antibody labeling yields compared with prior art manual extraction results of the prior art that can be expected to enable enhanced production of purified 211 At isotope products suitable for therapeutic medical applications such as treatment of cancer in human patients.
1. A method for producing a purified 211 At isotope product from dissolved cyclotron targets, the method comprising:
providing a separation media associated with 211 At isotopes; and
passing an At elution solution comprising HNO 3 through the separation media to elute 211 At isotopes from the separation media and provide 211 At isotopes in an HNO 3 solution.
2. The method of claim 1 wherein the providing the separation media associated with 211 At isotopes comprises:
preparing the separation media with conditioning solution comprising HCl to acidify the separation media; and
passing a 211 At/Bi solution through the separation media to associate 211 At isotopes with the media and recover Bi as an eluent.
3. The method of claim 2 further comprises dissolving a composition of 211 At and Bi-nitrate salts in an HCl solution to form the 211 At/Bi solution comprising the 211 At and Bi in an HCl solution.
4. The method of claim 3 further comprising dissolving a cyclotron target containing 211 At and Bi in a nitric acid solution to form the composition comprising 211 At and Bi-nitrate salts.
5. The method of claim 1 wherein the At elution solution has a molarity between 7.5M and 15.8M.
6. The method of claim 4 wherein the cyclotron target is a bismuth target.
7. The method of claim 1 wherein the separation media is a non-PEG media.
8. The method of claim 1 wherein the separation media is a macroporous polymer resin.