Wearable optical microfibrous material with encapsulated nanosensors for wireless monitoring of chemical analytes
An optical core-shell microfibrous textile incorporates single-walled carbon nanotubes (SWCNTs) for the real-time optical monitoring of hydrogen peroxide concentrations and other biochemicals in in vitro wounds. The environmentally sensitive and non-photo-bleachable fluorescence of SWCNTs enable continuous analyte monitoring without a decay in signal over time. The microfibrous textiles spatially resolve chemical indicator concentrations using a camera and are integrated into commercial wound bandages without significant degradation in their optical properties.
1. An optically reactive core-shell microfiber comprising:
a core comprising:
a first polymer; and
a plurality of optically reactive, functionalized single walled carbon nano tubes (SWCNTs) dispersed within the polymer; and
a shell comprising:
a second polymer disposed coaxially about the core,
said second polymer comprising a biocompatible, biodegradable, bioresorbable polymer,
said microfiber having a diameter (Df) in the range of 0.5 μm to 30 μm, a core diameter size (Dc) in the range of 0.25 μm to 20 μm, and a shell thickness (Ts) range of 0.25 μm to 10 μm.
2. The optically reactive core-shell microfiber of claim 1 wherein said microfiber has a diameter (Df) in the range of 5 μm to 10 μm, a core diameter size (Dc) in the range of 1 μm to 3 μm, and a shell thickness (Ts) range of 4 μm to 7 μm.
3. The optically reactive core-shell microfiber of claim 2 wherein said first polymer is selected from the group consisting of: Polyethylene oxide, Polyvinyl alcohol (PVA), Polyvinylpyrrolidone (PVP), Collagen, Gelatin, Chitosan, Alginate, Polyacrylic acid (PAA), Polyacrylamides, Dextran, Cellulose, Hyaluronic acid (HA), Starch, Glycerol and combinations thereof.
4. The optically reactive core-shell microfiber of claim 2 wherein said second polymer is selected from the group consisting of: Polycaprolactone, Polyurethane (PU), Polycarbonate (PC), Nylon, Polystyrene, Polytetrafluoroethylene (PTFE), Polylactic acid (PLA), Polymethyl methacrylate (PMMA), Polyaniline (PANI), Polyacrylonitrile (PAN), Polylactic-co-glycolic acid (PLGA), Polydimethylsiloxane (PDMS) and combinations thereof.
5. The optically reactive core-shell microfiber of claim 2 wherein said second polymer comprises polycaprolactone.
6. The optically reactive core-shell microfiber of claim 1 , wherein said optically reactive, functionalized SWCNT is optically reactive to changes in levels of an oxidation-reduction (REDOX) analyte.
7. The optically reactive core-shell microfiber of claim 6 , wherein said optically reactive, functionalized SWCNT is optically reactive to changes in levels of hydrogen peroxide.
8. The optically reactive core-shell microfiber of claim 6 , wherein said optically reactive, functionalized SWCNT is optically reactive to changes in levels of dopamine.
9. The optically reactive core-shell microfiber of claim 1 wherein a density of said functionalized SWCNTs within said fiber is in the range of 0.001 wt/wt % to 0.0005 wt/wt % (weight of SWCNT/(weight of SWCNT+total weight of core and shell polymers)).
10. The optically reactive core-shell microfiber of claim 9 wherein said first polymer is selected from the group consisting of: Polyethylene oxide, Polyvinyl alcohol (PVA), Polyvinylpyrrolidone (PVP), Collagen, Gelatin, Chitosan, Alginate, Polyacrylic acid (PAA), Polyacrylamides, Dextran, Cellulose, Hyaluronic acid (HA), Starch, Glycerol and combinations thereof.
11. The optically reactive core-shell microfiber of claim 9 wherein said first polymer comprises Polyethylene oxide.
12. The optically reactive core-shell microfiber of claim 9 wherein said second polymer is selected from the group consisting of: Polycaprolactone, Polyurethane (PU), Polycarbonate (PC), Nylon, Polystyrene, Polytetrafluoroethylene (PTFE), Polylactic acid (PLA), Polymethyl methacrylate (PMMA), Polyaniline (PANI), Polyacrylonitrile (PAN), Polylactic-co-glycolic acid (PLGA), Polydimethylsiloxane (PDMS) and combinations thereof.
13. The optically reactive core-shell microfiber of claim 9 wherein said second polymer comprises polycaprolactone.
14. The optically reactive core-shell microfiber of claim 1 wherein said first polymer is selected from the group consisting of: Polyethylene oxide, Polyvinyl alcohol (PVA), Polyvinylpyrrolidone (PVP), Collagen, Gelatin, Chitosan, Alginate, Polyacrylic acid (PAA), Polyacrylamides, Dextran, Cellulose, Hyaluronic acid (HA), Starch, Glycerol and combinations thereof.
15. The optically reactive core-shell microfiber of claim 1 wherein said first polymer comprises Polyethylene oxide.
16. The optically reactive core-shell microfiber of claim 1 wherein said second polymer is selected from the group consisting of: Polycaprolactone, Polyurethane (PU), Polycarbonate (PC), Nylon, Polystyrene, Polytetrafluoroethylene (PTFE), Polylactic acid (PLA), Polymethyl methacrylate (PMMA), Polyaniline (PANI), Polyacrylonitrile (PAN), Polylactic-co-glycolic acid (PLGA), Polydimethylsiloxane (PDMS) and combinations thereof.
17. The optically reactive core-shell microfiber of claim 1 wherein said second polymer comprises polycaprolactone.
18. A core-shell microfiber comprising:
a core comprising:
a first polymer; and
a plurality of functionalized single walled carbon nano tubes (SWCNTs) dispersed within the polymer; and
a shell comprising:
a second polymer disposed coaxially about the core,
said second polymer comprising a biocompatible, biodegradable, bioresorbable polymer,
said microfiber having a diameter (Df) in the range of 0.2 μm to 30 μm, a core diameter size (Dc) in the range of 0.1 μm to 20 μm, and a shell thickness (Ts) range of 0.1 μm to 10 μm,
wherein said functionalized SWCNT is functionalized to detect hydrogen peroxide.
19. A core-shell microfiber comprising:
a core comprising:
a first polymer; and
a plurality of functionalized single walled carbon nano tubes (SWCNTs) dispersed within the polymer; and
a shell comprising:
a second polymer disposed coaxially about the core,
said second polymer comprising a biocompatible, biodegradable, bioresorbable polymer,
said microfiber having a diameter (Df) in the range of 0.2 μm to 30 μm, a core diameter size (Dc) in the range of 0.1 μm to 20 μm, and a shell thickness (Ts) range of 0.1 μm to 10 μm,
wherein said functionalized SWCNT is functionalized to detect dopamine.