IP Library Granted Patent US 12,533,319
Granted Patent B2
US 12,533,319 · App. 17/600,208 · Granted Jan 27, 2026

Dynamic clusters of atom particles activated in extracellular fluid

Inventors: Sookjai Wutthinitikornkit (Bangkok, TH); Yanee Wutthinitikornkit (Bangkok, TH); Yongsheng Qiu (Bangkok, TH)
Assignee: Seawagen Research Institute Zhengzhou
A61K9/1611
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Quick Facts
Patent No.
US 12,533,319
App. No.
17/600,208
Granted
Jan 27, 2026
Kind
B2
Abstract

Provided herein are dynamic clusters of atom particles activated in extracellular fluid intended to reverse the accumulation of advanced glycation end products which are closely related to chronic diseases. The manufacturing process involves material preparation, particle fragmentation, pH adjustment, selection of atom particles and construction of dynamic clusters through electromagnetic field and flow velocity adjustment, and separation of dynamic clusters from the liquid. The dynamic clusters of atom particles deal with advanced glycation end products, which are diverse in chemical nature, by responding to irregularities in the electromagnetic field disrupted by highly reactive free radicals advanced glycation end products emit. Such mechanism makes it possible to extend the applications to diseases related to irregular free radical activities other than chronic diseases like in HIV replication or neural signalling.

Claims (17)

1 . A process of manufacturing clusters of atom particles, comprising:

a. performing a material preparation, wherein the material preparation comprises processing a liquid, the liquid comprising at least one of plant extract, animal extract, or an electrolyte, by:

removing liquid contaminants immiscible in the liquid, wherein the liquid contaminants are at least oil particles; and

removing precipitated substances by phase separation or filtration from the liquid;

b. performing a particle fragmentation;

c. performing a pH adjustment, wherein the pH adjustment comprises adding calcium hydroxide or hydrochloric acid to the liquid to adjust pH level to 7.0-7.8;

d. performing a selection of atom particles and construction of clusters, wherein the selection of atom particles and construction of clusters are processed at temperatures below 310K,

wherein the selection of atom particles and construction of clusters comprises manipulating an electromagnetic field and providing a liquid flow velocity to control behaviors of particles in the liquid as the particles flow across a non-uniform electromagnetic field that turns a clear liquid into a colloidal suspension,

wherein the particles in the liquid regardless of their charge and polarity are propelled by the non-uniform electromagnetic field, wherein the liquid comprises 12.5604 g/l of chlorine, 6.8786 g/l of sodium, 0.8232 g/l of magnesium, 0.2638 g/l of calcium, 0.2566 g/l of potassium, 0.1159 g/l of zinc, 0.0644 g/l of strontium, and 0.0406 g/l of manganese; and

e. performing a separation of the clusters.

2 . The process of manufacturing dynamic clusters of atom particles according to claim 1 , wherein performing the material preparation comprises using non-toxic additives to supplement contents of the liquid; and filtering out sediment larger than 50 micrometers from the liquid.

3 . The process of manufacturing clusters of atom particles according to claim 1 , wherein performing the particle fragmentation comprises exposing the liquid to sunlight and applying ultrasonic vibration to fragment particles smaller than 50 micrometers into finer bits.

4 . The process of manufacturing clusters of atom particles according to claim 1 , wherein performing the separation of the clusters comprises sprinkling the colloidal suspension over a water-permeable sheet, thereby leaving the clusters in a form of an opaque white slurry on a surface of the water-permeable sheet.

5 . A cluster of atom particles obtained by the process of manufacturing clusters of atom particles according to claim 1 .

6 . The cluster of atom particles according to claim 5 , wherein the cluster is small enough to flow through capillaries 8 micrometers in diameter.

7 . The cluster of atom particles according to claim 5 , wherein constituent particles of the cluster are detachable at body temperature.

8 . The cluster of atom particles according to claim 5 , wherein the cluster is capable of reversing an accumulation of advanced glycation end products.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2025
From: WUTTHINITIKORNKIT, SOOKJAI; WUTTHINITIKORNKIT, YANEE; QIU, YONGSHENG
To: XICHUAN SEAWAGEN COMPANY LIMITED
Reel/Frame 073332/0042 →
CHANGE OF NAME Recorded Dec 30, 2025
From: XICHUAN SEAWAGEN COMPANY LIMITED
To: SEAWAGEN RESEARCH INSTITUTE ZHENGZHOU
Reel/Frame 074122/0258 →
Continuity (1)
Related Publication 20220202715A1 · Jun 30, 2022
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