Nanoclusters for delivery of therapeutics
The present invention discloses a nano-cluster that includes a plurality of nano-particles, wherein the nano-particles can disperse in response to an environmental cue. Also disclosed is a method of preventing, treating, or diagnosing a disease or condition in a subject comprising administering a therapeutically effective amount of a composition comprising nano-clusters of the present invention.
1. A nano-cluster comprising a plurality of nano-particles, wherein the nano-particles include an active ingredient and a polymer, and wherein the nano-cluster is not hollow.
2. The nano-cluster of claim 1 , wherein the active ingredient is bound to the surface of the nano-particles.
3. The nano-cluster of claim 1 , wherein the size of the nano-cluster is from about 1 to about 200 microns.
4. The nano-cluster of claim 1 , wherein the nano-cluster is solid.
5. The nano-cluster of claim 1 , wherein the nano-particles are not covalently bonded together.
6. The nano-cluster of claim 1 , wherein the nano-particles are not encapsulated.
7. The nano-cluster of claim 1 , wherein the nano-particles disperse in response to an environmental cue.
8. The nano-cluster of claim 1 , wherein the nano-particle is solid.
9. The nano-cluster of claim 1 , wherein the nano-particle is hollow.
10. The nano-cluster of claim 1 , further comprising a dispersing material that disperses the nano-particles in response to an environmental cue.
11. The nano-cluster of claim 10 , wherein the dispersing material comprises a water soluble polymer, a biodegradable polymer, a polyelectrolyte, a metal, a polymeric cross-linker, a small molecule cross-linker, a pH sensitive material, a surfactant, or a temperature sensitive material.
12. The nano-cluster of claim 10 , wherein the environmental cue is water, a selected pH, a selected temperature, the presence of a selected enzyme, the presence of a selected chemical, the presence of a selected electromagnetic wavelength range, or the presence of vibration or shearing.
13. The nano-cluster of claim 1 , comprising at least 50% by weight of nano-particles.
14. The nano-cluster of claim 1 , wherein the nano-cluster is comprised in a composition.
15. The nano-cluster of claim 14 , wherein the composition further comprises an active ingredient.
16. The nano-cluster of claim 14 , wherein the composition is formulated into a dry powder, an aerosol, a spray, a tablet, or a liquid.
17. The nano-cluster of claim 14 , wherein the composition is formulated into a pharmaceutically acceptable carrier.
18. A nano-cluster comprising a plurality of nano-particles, wherein the nano-particles include an active ingredient and a biodegradable polymer, and wherein the nano-cluster is not hollow.
19. The nano-cluster of claim 18 , wherein the active ingredient is bound to the surface of the nano-particles.
20. The nano-cluster of claim 18 , wherein the size of the nano-cluster is from about 1 to about 200 microns.
21. The nano-cluster of claim 18 , wherein the nano-cluster is solid.
22. The nano-cluster of claim 18 , wherein the nano-particles are not covalently bonded together.
23. The nano-cluster of claim 18 , wherein the nano-particles are not encapsulated.
24. The nano-cluster of claim 18 , wherein the nano-particles disperse in response to an environmental cue.
25. The nano-cluster of claim 18 , wherein the nano-particle is solid.
26. The nano-cluster of claim 18 , wherein the nano-particle is hollow.
27. The nano-cluster of claim 18 , further comprising a dispersing material that disperses the nano-particles in response to an environmental cue.
28. The nano-cluster of claim 27 , wherein the dispersing material comprises a water soluble polymer, a biodegradable polymer, a polyelectrolyte, a metal, a polymeric cross-linker, a small molecule cross-linker, a pH sensitive material, a surfactant, or a temperature sensitive material.
29. The nano-cluster of claim 27 , wherein the environmental cue is water, a selected pH, a selected temperature, the presence of a selected enzyme, the presence of a selected chemical, the presence of a selected electromagnetic wavelength range, or the presence of vibration or shearing.
30. The nano-cluster of claim 18 , comprising at least 50% by weight of nano-particles.
31. The nano-cluster of claim 18 , wherein the nano-cluster is comprised in a composition.
32. The nano-cluster of claim 31 , wherein the composition further comprises an active ingredient.
33. The nano-cluster of claim 31 , wherein the composition is formulated into a dry powder, an aerosol, a spray, a tablet, or a liquid.
34. The nano-cluster of claim 31 , wherein the composition is formulated into a pharmaceutically acceptable carrier.
35. A nano-cluster comprising a plurality of nano-particles, wherein the nano-particles include an active ingredient, and wherein the nano-cluster is not hollow and is comprised in a composition formulated into a dry powder, an aerosol, a spray, a tablet, or a liquid.
36. The nano-cluster of claim 35 , wherein the active ingredient is bound to the surface of the nano-particles.
37. The nano-cluster of claim 35 , wherein the size of the nano-cluster is from about 1 to about 200 microns.
38. The nano-cluster of claim 35 , wherein the nano-cluster is solid.
39. The nano-cluster of claim 35 , wherein the nano-particles are not covalently bonded together.
40. The nano-cluster of claim 35 , wherein the nano-particles are not encapsulated.
41. The nano-cluster of claim 35 , wherein the nano-particles disperse in response to an environmental cue.
42. The nano-cluster of claim 35 , wherein the nano-particle is solid.
43. The nano-cluster of claim 35 , wherein the nano-particle is hollow.
44. The nano-cluster of claim 35 , further comprising a dispersing material that disperses the nano-particles in response to an environmental cue.
45. The nano-cluster of claim 44 , wherein the dispersing material comprises a water soluble polymer, a biodegradable polymer, a polyelectrolyte, a metal, a polymeric cross-linker, a small molecule cross-linker, a pH sensitive material, a surfactant, or a temperature sensitive material.
46. The nab-cluster of claim 44 , wherein the environmental cue is water, a selected pH, a selected temperature, the presence of a selected enzyme, the presence of a selected chemical, the presence of a selected electromagnetic wavelength range, or the presence of vibration or shearing.
47. The nano-cluster of claim 35 , comprising at least 50% by weight of nano-particles.
48. The nano-cluster of claim 35 , wherein the composition further comprises an active ingredient.
49. A nano-cluster comprising a plurality of nano-particles, wherein the nano-particles include an active ingredient, and wherein the nano-cluster is not hollow and is comprised in a composition formulated into a pharmaceutically acceptable carrier.
50. The nano-cluster of claim 49 , wherein the active ingredient is bound to the surface of the nano-particles.
51. The nano-cluster of claim 49 , wherein the size of the nano-cluster is from about 1 to about 200 microns.
52. The nano-cluster of claim 49 , wherein the nano-cluster is solid.
53. The nano-cluster of claim 49 , wherein the nano-particles are not covalently bonded together.
54. The nano-cluster of claim 49 , wherein the nano-particles are not encapsulated.
55. The nano-cluster of claim 49 , wherein the nano-particles disperse in response to an environmental cue.
56. The nano-cluster of claim 49 , wherein the nano-particle is solid.
57. The nano-cluster of claim 49 , wherein the nano-particle is hollow.
58. The nano-cluster of claim 49 , further comprising a dispersing material that disperses the nano-particles in response to an environmental cue.
59. The nano-cluster of claim 58 , wherein the dispersing material comprises a water soluble polymer, a biodegradable polymer, a polyelectrolyte, a metal, a polymeric cross-linker, a small molecule cross-linker, a pH sensitive material, a surfactant, or a temperature sensitive material.
60. The nano-cluster of claim 58 , wherein the environmental cue is water, a selected pH, a selected temperature, the presence of a selected enzyme, the presence of a selected chemical, the presence of a selected electromagnetic wavelength range, or the presence of vibration or shearing.
61. The nano-cluster of claim 49 , comprising at least 50% by weight of nano-particles.
62. The nano-cluster of claim 49 , wherein the composition further comprises an active ingredient.