Polyurethane gels
The present invention relates to gel compositions comprising a polyurethane elastomer. The polyurethane elastomer is formed from the reaction of a polyol, a polyisocyanate, and optionally a polyurethane reaction catalyst, optionally in the presence of a topically acceptable carrier fluid. In some embodiments, the gel composition comprises a personal active ingredient or a healthcare active ingredient, which may be incorporated into the gel composition via a pre-load method or a post-load method. Also provided herein are gel pastes and topical formulations comprising the polyurethane elastomers, and methods of making the same.
1 . A gel composition comprising a polyurethane elastomer gel containing a reaction product of:
(A) a polyisocyanate or a mixture of polyisocyanates comprising two or more isocyanate functional groups;
(B) a polyol or mixture of polyols comprising two or more hydroxyl functional groups;
(C) polyurethane reaction catalyst; and
(D) topically acceptable carrier fluid acting as a solvent, the topically acceptable carrier fluid being selected from the group consisting of esters, triglycerides, hydrocarbons, oils, and combinations thereof, and the solvent being acceptable for cutaneous surfaces;
wherein the reaction product has an elastomeric matrix with the topically acceptable carrier fluid entrapped in the elastomeric matrix; and
wherein the composition is silicone-free.
2 . The gel composition of claim 1 , wherein the topically acceptable carrier fluid comprises diisooctyl succinate, heptyl undecylenate, neopentyl glycol diheptanoate, coco-caprylate/caprate, triheptanoin, caprylic/capric triglyceride, dodecane, tridecane, C13-15 alkane, squalene, squalene, isoamyl laurate, isopentyl laurate, caprylic/capric/myristic/stearic triglyceride, caprylic/capric/succinic triglyceride, isopropyl myristate, jojoba esters, tricaprylin, palm oil or combinations thereof.
3 . The gel composition of claim 1 , wherein a pharmaceutically active ingredient is dissolved in the topically acceptable carrier fluid.
4 . The gel composition of claim 1 , wherein the polyurethane reaction catalyst is a bismuth group containing catalyst.
5 . The gel composition of claim 1 , wherein greater than 50% of the carbon content of the topically acceptable carrier fluid is derived from one or more plant sources.
6 . The gel composition of claim 1 , wherein the polyol is a branched C 36 dicarboxylic acid/diol copolymer.
7 . The gel composition of claim 6 , wherein the branched C 36 dicarboxylic acid/diol copolymer is dilinoleic acid/propane diol copolymer or dilinoleic acid/dilinoleic diol copolymer.
8 . The gel composition of claim 1 , wherein the composition is in the form of a sunscreen, an oil-in-water emulsion, or a water-in-emulsion.
9 . A gel composition comprising a polyurethane elastomer gel containing a reaction product of:
(A) castor oil, dilinoleic acid/propane diol copolymer, or dilinoleic acid/dilinoleic diol copolymer;
(B) isophorone diisocyanate, pentamethylene diisocyanate trimer or hexamethylene diisocyanate trimer, wherein a molar ratio of isocyanate groups to hydroxyl groups is about 1:1 to about 1:2;
(C) polyurethane reaction catalyst; and
(D) topically acceptable carrier fluid acting as a solvent at a concentration of 60% (w/w) to 99.9% (w/w) of the gel composition, the topically acceptable carrier fluid being selected from the group consisting of esters, triglycerides, hydrocarbons, oils, and combinations thereof, and the solvent being acceptable for cutaneous surfaces;
wherein a personal care or healthcare active ingredient is optionally incorporated into the polyurethane elastomer gel by dissolving the personal care or healthcare active ingredient in the topically acceptable carrier fluid during formation of the polyurethane elastomer gel, or by admixing the personal care or healthcare active ingredient with a formed polyurethane elastomer gel;
wherein the reaction product has an elastomeric matrix with the topically acceptable carrier fluid entrapped in the elastomeric matrix; and
wherein the composition is silicone-free.
10 . The gel composition of claim 9 , wherein the topically acceptable carrier fluid comprises diisooctyl succinate, heptyl undecylenate, neopentyl glycol diheptanoate, and coco-caprylate/caprate or combinations thereof.
11 . The gel composition of claim 9 , wherein a pharmaceutically active ingredient is dissolved in the topically acceptable carrier fluid.
12 . The gel composition of claim 9 , wherein the polyurethane reaction catalyst is a bismuth group containing catalyst.
13 . The gel composition of claim 9 , wherein greater than 50% of the carbon content of the topically acceptable carrier fluid is derived from one or more plant sources.