IP Library › Granted Patent US 12,257,325
Granted Patent B2
US 12,257,325 · App. 17/643,734 · Granted Mar 25, 2025

Chelating platform for delivery of radionuclides

Inventors: Roland K. Strong (Seattle, WA); Peter Rupert (Seattle, WA); Rebecca J. Abergel (Berkeley, CA); Ilya Captain (Moraga, CA); Gauthier J P Deblonde (Berkeley, CA)
Assignees: Fred Hutchinson Cancer Research Center; The Regents of the University of California
A61K51/0482A61K51/0478B01D15/34B01D15/3804C07K14/47C22B60/02
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Quick Facts
Patent No.
US 12,257,325
App. No.
17/643,734
Filed
Dec 10, 2021
Granted
Mar 25, 2025
Kind
B2
Art Unit
1618
USPC
424/1.69
Abstract

Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.

Claims (32)

1. A composition comprising a compound or a salt thereof bound to a metal and a siderocalin, the compound having a structure of Formula II:

wherein:

at least one of R 1 , R 2 , R 3 , R 4 , and R 5 , individually, is

(CAM group);

(HA group), wherein R a is H or a C1-C5 alkyl group; or

(1,2-HOPO group);

at least another one of R 1 , R 2 , R 3 , R 4 , and R 5 , individually, is H, an alkyl group having from 1 to 10 carbon atoms;

R 6 is (i) H, (ii) an alkyl group having from 1 to 10 carbon atoms, or (iii) an alkyl group having from 1 to 10 carbon atoms and substituted by at least one of SH, NH 2 , or C(═O) OH;

m is from 1 to 6;

n is from 1 to 6; and

o is from 1 to 6, and wherein the siderocalin comprises any one of SEQ ID NOs: 1-25.

2. The composition of claim 1 , the compound having a structure of Formula III:

wherein:

at least one of R 1 , R 2 , R 3 , R 4 , and R 5 , individually, is a CAM group, a HA group, or a 1,2-HOPO group; optionally, another one of R 1 , R 3 , R 4 , or R 5 , individually, is H or an alkyl group having from 1 to 10 carbon atoms;

R 2 is H or a C1-C5 alkyl group;

R 7 is SH, C(═O) OH, or NH 2 ; and

p is from 0 to 4;

and optionally, wherein:

R 1 is a CAM group or a 1,2-HOPO group;

each of R 3 and R 4 , individually, is a HA group, wherein R a is H or a C1-C5 alkyl group; and

R 5 is a CAM group, a 1,2-HOPO group, or a HA group, wherein R a is H or a C1-C5 alkyl group.

3. The composition of claim 2 , the compound having a structure of Formula IV, V, VI or VII:

wherein:

R 7 is SH, NH 2 , or C(═O) OH;

each of R 2 , R 8 , and R 9 , individually, is H or a C1-C5 alkyl group; and

p is from 0 to 4.

4. The composition of claim 2 , the compound having a structure of Formula VIII or IX:

wherein:

R 7 is SH, C(═O) OH, or NH 2 ;

each of R 2 , R 8 , R 9 , and R 10 , individually, is an H or a C1-C5 alkyl group; and

p is from 0 to 4.

5. The composition of claim 2 , the compound having a structure of Formula X or XI:

Assignments (3)
MERGER AND CHANGE OF NAME Recorded Jun 23, 2022
From: FRED HUTCHINSON CANCER RESEARCH CENTER; SEATTLE CANCER CARE ALLIANCE
To: FRED HUTCHINSON CANCER CENTER
Reel/Frame 060438/0369 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 16, 2021
From: STRONG, RONALD K.; RUPERT, PETER
To: FRED HUTCHINSON CANCER RESEARCH CENTER
Reel/Frame 058403/0533 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 16, 2021
From: ABERGEL, REBECCA J.; CAPTAIN, ILYA; DEBLONDE, GAUTHIER JP
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 058403/0603 →
Continuity (5)
Division 16329178
Provisional Application 62505458 · May 12, 2017
Provisional Application 62401687 · Sep 29, 2016
Provisional Application 62380885 · Aug 29, 2016
Related Publication 20220160904A1 · May 26, 2022
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