Granted Patent
B2
US 12,201,834 · App. 17/649,517 · Granted Jan 21, 2025
Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
Inventors:
Jonathan D. Charlesworth (Menlo Park, CA); Sumon K. Pal (Boston, MA); William J. Tyler (Tempe, AZ); Daniel Z. Wetmore (Brooklyn, NY); Isy Goldwasser (Los Gatos, CA); Alyssa M. Boasso (Brookline, MA); Hailey M. Mortimore (Boston, MA); Rafal Piersiak (Los Gatos, CA)
Assignee:
Thync Global, Inc.
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Abstract
Portable transdermal electrical stimulation (TES) applicators for modifying a subject's cognitive state by applying stimulation to the subject's skin. One or more electrode may be on the subject's mastoid, and/or on or near the back of the subject's neck. The portable applicators are configured and adapted to be lightweight and may be wearable, and to deliver a high-intensity TES able to evoke or enhance a predetermined cognitive effect to stimulate either the trigeminal, facial and/or cervical plexus. These TES applicators may include a pair of electrodes and a TES control module comprising a processor, a timer and a waveform generator.
Claims (27)
1. A method of modifying a subject's sympathetic nervous system, the method comprising:
delivering a transdermal electrical stimulation between an anode at a first location on the subject's skin on the back of the subject's neck, and a cathode positioned at a second location on the subject's skin on the back of the subject's neck;
wherein the transdermal electrical stimulation between the anode and cathode is applied until the subject's sympathetic nervous system is suppressed,
wherein delivering the transdermal electrical stimulation comprises applying a first capacitive discharge current at an end of a positive-going pulse and/or applying a second capacitive discharge current at an end of a negative-going pulse, wherein the first and second capacitive discharge currents correspond to spikes in current.
2. The method of claim 1 , wherein the first location is a medial portion of the subject's neck, and the second location is above the first location.
3. The method of claim 1 , wherein the first location is a medial portion of the subject's neck, and the second location is below the first location.
4. The method of claim 1 , wherein the transdermal electrical stimulation is pulsed, asymmetric and biphasic.
5. The method of claim 4 , wherein the pulsed, asymmetric and biphasic transdermal electrical stimulation is applied in intervals having a frequency of 250 Hz or greater and an intensity of greater than 3 mA.
6. The method of claim 1 , wherein the transdermal electrical stimulation has a frequency of 250 Hz or greater and an intensity of greater than 3 mA.
7. The method of claim 1 , wherein the transdermal electrical stimulation is applied for 10 seconds or longer.
8. The method of claim 1 , wherein a time constant for return of the first capacitive discharge current is sufficiently long such that an adjacent negative-going pulse rides on a return portion of the first capacitive discharge current.
9. The method of claim 1 , wherein the transdermal electrical stimulation has a duty cycle of greater than 10 percent.
10. The method of claim 1 , further comprising varying the transdermal electrical stimulation while the transdermal electrical stimulation is applied.
11. A method of modifying a subject's sympathetic nervous system, the method comprising:
positioning an anode and a cathode on the subject's skin on the back of the subject's neck;
activating a wearable transdermal electrical stimulation applicator to deliver a transdermal electrical stimulation between the anode and the cathode; and
applying the transdermal electrical stimulation between the anode and the cathode until the subject's sympathetic nervous system is suppressed,
wherein applying the transdermal electrical stimulation comprises applying a first capacitive discharge current at an end of a positive-going pulse and/or applying a second capacitive discharge current at an end of a negative-going pulse, wherein the first and second capacitive discharge currents correspond to spikes in current.
12. The method of claim 11 , wherein the anode is smaller than the cathode.
13. The method of claim 11 , wherein the anode is positioned at a first location on the back of the subject's neck, and the cathode is positioned at second location above or below the first location on the back of the subject's neck.
14. The method of claim 11 , wherein the anode is positioned at a first location on the back of the subject's neck, and the cathode is positioned laterally with respect to the first location on the back of the subject's neck.
15. The method of claim 11 , wherein activating the wearable transdermal electrical stimulation applicator comprises wirelessly triggering activation of the wearable transdermal electrical stimulation applicator.
16. A method of modifying a subject's sympathetic nervous system, the method comprising:
positioning an anode and a cathode on a medial portion of the subject's neck;
activating a transdermal electrical stimulation applicator to deliver a transdermal electrical stimulation between the anode and the cathode, wherein the transdermal electrical stimulation is applied between the anode and the cathode until the subject's sympathetic nervous system is suppressed; and
applying a capacitive discharge current to the anode and the cathode to oppose a capacitance built-up during the application of the transdermal electrical stimulation, wherein applying the capacitive discharge current comprises applying a first capacitive discharge current at an end of a positive-going pulse and/or applying a second capacitive discharge current at an end of a negative-going pulse, the first and second capacitive discharge currents corresponding to spikes in current.
17. The method of claim 16 , further comprising ramping the transdermal electrical stimulation by modifying one or more of an intensity, a frequency and a duty cycle from an initial state and then restoring the one or more of the intensity, the frequency and the duty cycle back to the initial state.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 19, 2024
From: CHARLESWORTH, JONATHAN D.; PAL, SUMON K.; TYLER, WILLIAM J.; WETMORE, DANIEL Z.; GOLDWASSER, ISY; BOASSO, ALYSSA M.; MORTIMORE, HAILEY M.; PIERSIAK, RAFAL
To: THYNC GLOBAL, INC.
Reel/Frame 068331/0050 →
Continuity (7)
Provisional Application
62281326
· Jan 21, 2016
Provisional Application
62279992
· Jan 18, 2016
Provisional Application
62269975
· Dec 19, 2015
Provisional Application
62269104
· Dec 18, 2015
References Cited (400)
US 3255753A
· Wing
· 1966
[cited by applicant]
US 3388699A
· Webb et al.
· 1968
[cited by applicant]
US 3620219A
· Barker
· 1971
[cited by applicant]
US 3648708A
· Haeri
· 1972
[cited by applicant]
US 3762396A
· Ballentine et al.
· 1973
[cited by applicant]
US 4418687A
· Matsumoto et al.
· 1983
[cited by applicant]
US 4431000A
· Butler et al.
· 1984
[cited by applicant]
US 4541432A
· Molina-Negro et al.
· 1985
[cited by applicant]
US 4646744A
· Capel
· 1987
[cited by applicant]
US 4664117A
· Beck
· 1987
[cited by applicant]
US 4865048A
· Eckerson
· 1989
[cited by applicant]
US 5144952A
· Frachet et al.
· 1992
[cited by applicant]
US 5183041A
· Toriu et al.
· 1993
[cited by applicant]
US 5222494A
· Baker
· 1993
[cited by applicant]
US 5335657A
· Terry et al.
· 1994
[cited by applicant]
US 5342410A
· Braverman
· 1994
[cited by applicant]
US 5397338A
· Grey et al.
· 1995
[cited by applicant]
US 5476481A
· Schondorf
· 1995
[cited by applicant]
US 5487759A
· Bastyr et al.
· 1996
[cited by applicant]
US 5514175A
· Kim et al.
· 1996
[cited by applicant]
US 5540736A
· Haimovich et al.
· 1996
[cited by applicant]
US 5573552A
· Hansjurgens
· 1996
[cited by applicant]
US 5578065A
· Hattori et al.
· 1996
[cited by applicant]
US 5593427A
· Gliner et al.
· 1997
[cited by applicant]
US 5738647A
· Bernhard et al.
· 1998
[cited by applicant]
US 5792067A
· Karell
· 1998
[cited by applicant]
US 6066163A
· John
· 2000
[cited by applicant]
US 6280454B1
· Wang
· 2001
[cited by applicant]
US 6324432B1
· Rigaux et al.
· 2001
[cited by applicant]
US 6445955B1
· Michelson et al.
· 2002
[cited by applicant]
US 6463328B1
· John
· 2002
[cited by applicant]
US 6516227B1
· Meadows et al.
· 2003
[cited by applicant]
US 6526318B1
· Ansarinia
· 2003
[cited by applicant]
US 6567702B1
· Nekhendzy et al.
· 2003
[cited by applicant]
US 6731987B1
· McAdams et al.
· 2004
[cited by applicant]
US 6983184B2
· Price
· 2006
[cited by applicant]
US 7120499B2
· Thrope et al.
· 2006
[cited by applicant]
US 7146217B2
· Firlik et al.
· 2006
[cited by applicant]
US 7263501B2
· Tirinato et al.
· 2007
[cited by applicant]
US 7376467B2
· Thrope et al.
· 2008
[cited by applicant]
US 7422555B2
· Zabara
· 2008
[cited by applicant]
US 7577481B2
· Firlik et al.
· 2009
[cited by applicant]
US 7660636B2
· Castel et al.
· 2010
[cited by applicant]
US 7801600B1
· Carbunaru et al.
· 2010
[cited by applicant]
US 7891615B2
· Bevirt
· 2011
[cited by applicant]
US 7949403B2
· Palermo et al.
· 2011
[cited by applicant]
US 8029431B2
· Tononi
· 2011
[cited by applicant]
US 8034294B1
· Goldberg
· 2011
[cited by applicant]
US 8086318B2
· Strother et al.
· 2011
[cited by applicant]
US 8097926B2
· De Graff et al.
· 2012
[cited by applicant]
US 8116875B2
· Osypka et al.
· 2012
[cited by applicant]
US 8121695B2
· Gliner et al.
· 2012
[cited by applicant]
US 8150537B2
· Tanaka et al.
· 2012
[cited by applicant]
US 8190248B2
· Besio et al.
· 2012
[cited by applicant]
US 8197276B2
· Egloff et al.
· 2012
[cited by applicant]
US 8204601B2
· Moyer et al.
· 2012
[cited by applicant]
US 8239030B1
· Hagedorn et al.
· 2012
[cited by applicant]
US 8265761B2
· Siever
· 2012
[cited by applicant]
US 8280502B2
· Hargrove et al.
· 2012
[cited by applicant]
US 8346337B2
· Heller et al.
· 2013
[cited by applicant]
US 8380315B2
· DeGiorgio et al.
· 2013
[cited by applicant]
US 8428738B2
· Valencia
· 2013
[cited by applicant]
US 8463383B2
· Sakai et al.
· 2013
[cited by applicant]
US 8494625B2
· Hargrove
· 2013
[cited by applicant]
US 8494627B2
· Bikson et al.
· 2013
[cited by applicant]
US 8506469B2
· Dietrich et al.
· 2013
[cited by applicant]
US 8532758B2
· Silverstone
· 2013
[cited by applicant]
US 8560075B2
· Covalin
· 2013
[cited by applicant]
US 8571651B2
· Ben-Ezra et al.
· 2013
[cited by applicant]
US 8583238B1
· Heldman et al.
· 2013
[cited by applicant]
US 8583256B2
· Tracey et al.
· 2013
[cited by applicant]
US 8612005B2
· Rezal et al.
· 2013
[cited by applicant]
US 8639343B2
· De Vos
· 2014
[cited by applicant]
US 8660644B2
· Jaax et al.
· 2014
[cited by applicant]
US 8688239B2
· Hartlep et al.
· 2014
[cited by applicant]
US 8843210B2
· Simon et al.
· 2014
[cited by applicant]
US 8874219B2
· Trier et al.
· 2014
[cited by applicant]
US 8903494B2
· Goldwasser et al.
· 2014
[cited by applicant]
US 8983621B2
· Hou et al.
· 2015
[cited by applicant]
US 9002458B2
· Pal et al.
· 2015
[cited by applicant]
US 9014811B2
· Pal et al.
· 2015
[cited by applicant]
US 9067054B2
· Simon et al.
· 2015
[cited by applicant]
US 9168374B2
· Su
· 2015
[cited by applicant]
US 9205258B2
· Simon et al.
· 2015
[cited by applicant]
US 9233244B2
· Pal et al.
· 2016
[cited by applicant]
US 9248292B2
· Trier et al.
· 2016
[cited by applicant]
US 9333334B2
· Jeffery et al.
· 2016
[cited by applicant]
US 9364674B2
· Cook et al.
· 2016
[cited by applicant]
US 9393401B2
· Goldwasser et al.
· 2016
[cited by applicant]
US 9393430B2
· Demers et al.
· 2016
[cited by applicant]
US 9399126B2
· Pal et al.
· 2016
[cited by applicant]
US 9415219B2
· Simon et al.
· 2016
[cited by applicant]
US 9440070B2
· Goldwasser et al.
· 2016
[cited by applicant]
US 9446242B2
· Griffith
· 2016
[cited by applicant]
US 9474891B2
· Demers et al.
· 2016
[cited by applicant]
US 9474905B2
· Doan et al.
· 2016
[cited by applicant]
US 9517351B2
· Charlesworth et al.
· 2016
[cited by applicant]
US 9655772B2
· Smith et al.
· 2017
[cited by applicant]
US 9656076B2
· Trier et al.
· 2017
[cited by applicant]
US 9700725B2
· Zhu
· 2017
[cited by applicant]
US 9731116B2
· Chen
· 2017
[cited by applicant]
US 9744347B2
· Chen et al.
· 2017
[cited by applicant]
US 9764133B2
· Thomas et al.
· 2017
[cited by applicant]
US 9782587B2
· Trier et al.
· 2017
[cited by applicant]
US 9956405B2
· Goldwasser et al.
· 2018
[cited by applicant]
US 9968780B2
· Pal et al.
· 2018
[cited by applicant]
US 20010000187A1
· Peckham et al.
· 2001
[cited by applicant]
US 20030134545A1
· McAdams et al.
· 2003
[cited by applicant]
US 20040098065A1
· Hagglof et al.
· 2004
[cited by applicant]
US 20050165460A1
· Erfan
· 2005
[cited by applicant]
US 20050267388A1
· Hanna
· 2005
[cited by applicant]
US 20050283259A1
· Wolpow
· 2005
[cited by applicant]
US 20060047215A1
· Newman et al.
· 2006
[cited by applicant]
US 20060149119A1
· Wang
· 2006
[cited by applicant]
US 20060190057A1
· Reese
· 2006
[cited by applicant]
US 20060247985A1
· Liamos et al.
· 2006
[cited by applicant]
US 20070053466A1
· Klostermann
· 2007
[cited by applicant]
US 20070088419A1
· Fiorina et al.
· 2007
[cited by applicant]
US 20070173890A1
· Armstrong
· 2007
[cited by applicant]
US 20080045882A1
· Finsterwald
· 2008
[cited by applicant]
US 20080071626A1
· Hill
· 2008
[cited by applicant]
US 20080097564A1
· Lathrop
· 2008
[cited by applicant]
US 20080281368A1
· Bulkes et al.
· 2008
[cited by applicant]
US 20080319505A1
· Boyden et al.
· 2008
[cited by applicant]
US 20090048642A1
· Goroszeniuk
· 2009
[cited by applicant]
US 20090076559A1
· Libbus et al.
· 2009
[cited by applicant]
US 20090099623A1
· Bentwich
· 2009
[cited by applicant]
US 20090177243A1
· Lebedev et al.
· 2009
[cited by applicant]
US 20090287108A1
· Levy
· 2009
[cited by applicant]
US 20100057154A1
· Dietrich et al.
· 2010
[cited by applicant]
US 20100145399A1
· Johari et al.
· 2010
[cited by applicant]
US 20100145428A1
· Cameron et al.
· 2010
[cited by applicant]
US 20100222734A1
· Jayes et al.
· 2010
[cited by applicant]
US 20100256436A1
· Partsch et al.
· 2010
[cited by applicant]
US 20110034756A1
· Hacking et al.
· 2011
[cited by applicant]
US 20110082326A1
· Mishelevich et al.
· 2011
[cited by applicant]
US 20110112394A1
· Mishelevich
· 2011
[cited by applicant]
US 20110172752A1
· Bingham et al.
· 2011
[cited by applicant]
US 20110230702A1
· Honour
· 2011
[cited by applicant]
US 20110270345A1
· Johnston et al.
· 2011
[cited by applicant]
US 20110307029A1
· Hargrove
· 2011
[cited by applicant]
US 20120109251A1
· Lebedev et al.
· 2012
[cited by applicant]
US 20120245409A1
· Liang
· 2012
[cited by applicant]
US 20120245653A1
· Bikson et al.
· 2012
[cited by applicant]
US 20120306628A1
· Singhal
· 2012
[cited by applicant]
US 20130060304A1
· La Tendresse et al.
· 2013
[cited by applicant]
US 20130079659A1
· Akhadov et al.
· 2013
[cited by applicant]
US 20130131551A1
· Raghunathan et al.
· 2013
[cited by applicant]
US 20130155561A1
· Chein-Feng
· 2013
[cited by applicant]
US 20130204315A1
· Wongsampigoon et al.
· 2013
[cited by applicant]
US 20130253613A1
· Salahovic et al.
· 2013
[cited by applicant]
US 20130318168A1
· Demain et al.
· 2013
[cited by applicant]
US 20140128944A1
· Stern et al.
· 2014
[cited by applicant]
US 20140222102A1
· Lemus et al.
· 2014
[cited by applicant]
US 20140257449A1
· Helmer
· 2014
[cited by applicant]
US 20140275933A1
· Meyer et al.
· 2014
[cited by applicant]
US 20140324138A1
· Wentz et al.
· 2014
[cited by applicant]
US 20140371814A1
· Spizzirri et al.
· 2014
[cited by applicant]
US 20150224310A1
· Sharma et al.
· 2015
[cited by applicant]
US 20150257970A1
· Mucke et al.
· 2015
[cited by applicant]
US 20150335877A1
· Jeffery et al.
· 2015
[cited by applicant]
US 20150360038A1
· Zottola
· 2015
[cited by examiner]
US 20160008632A1
· Wetmore et al.
· 2016
[cited by applicant]
US 20160074657A1
· Kwan et al.
· 2016
[cited by applicant]
US 20170076414A1
· Egnal et al.
· 2017
[cited by applicant]
US 20200147340A1
· Tyler et al.
· 2020
[cited by applicant]
US 20200155790A9
· Tyler et al.
· 2020
[cited by applicant]
US 20200297999A1
· Pal
· 2020
[cited by applicant]
CN 1204268A
· 1999
[cited by applicant]
CN 1607970A
· 2005
[cited by applicant]
CN 1704131A
· 2005
[cited by applicant]
CN 1842356A
· 2006
[cited by applicant]
CN 101234233A
· 2008
[cited by applicant]
CN 101244314A
· 2008
[cited by applicant]
CN 201353374Y
· 2009
[cited by applicant]
CN 102245253A
· 2011
[cited by applicant]
CN 102725021A
· 2012
[cited by applicant]
CN 102906752A
· 2013
[cited by applicant]
CN 103517732A
· 2014
[cited by applicant]
EP 502919B1
· 1993
[cited by applicant]
EP 801957A1
· 1997
[cited by applicant]
EP 09965358A2
· 1999
[cited by applicant]
EP 1529550A1
· 2005
[cited by applicant]
EP 1502623B1
· 2007
[cited by applicant]
EP 1551290B1
· 2008
[cited by applicant]
EP 2024018A2
· 2009
[cited by applicant]
EP 2314346A1
· 2011
[cited by applicant]
EP 1559369B1
· 2012
[cited by applicant]
EP 2069001B1
· 2013
[cited by applicant]
JP 49061984A
· 1974
[cited by applicant]
JP 05031197A
· 1993
[cited by applicant]
JP 06339531A
· 1994
[cited by applicant]
JP 10108913A
· 1998
[cited by applicant]
JP 2001129100A
· 2001
[cited by applicant]
JP 2001293097A
· 2001
[cited by applicant]
JP 2002306604A
· 2002
[cited by applicant]
JP 200310230A
· 2003
[cited by applicant]
JP 2006192302A
· 2006
[cited by applicant]
JP 3129187U
· 2007
[cited by applicant]
JP 2007535372A
· 2007
[cited by applicant]
JP 200985901A
· 2009
[cited by applicant]
JP 2009513248A
· 2009
[cited by applicant]
JP 2011118293A
· 2011
[cited by applicant]
JP 2011519654A
· 2011
[cited by applicant]
JP 2013512076A
· 2013
[cited by applicant]
WO WO9009810A1
· 1990
[cited by applicant]
WO WO9206737A1
· 1992
[cited by applicant]
WO WO9317628A1
· 1993
[cited by applicant]
WO WO9400188A1
· 1994
[cited by applicant]
WO WO9400189A1
· 1994
[cited by applicant]
WO WO0108071A1
· 2001
[cited by applicant]
WO WO0178834A1
· 2001
[cited by applicant]
WO WO03018120A1
· 2003
[cited by applicant]
WO WO03105945A2
· 2003
[cited by applicant]
WO WO2005110531A1
· 2005
[cited by applicant]
WO WO2006113801A2
· 2006
[cited by applicant]
WO WO2006138702A2
· 2006
[cited by applicant]
WO WO2008155114A1
· 2008
[cited by applicant]
WO WO2009089014A1
· 2009
[cited by applicant]
WO WO2009137683A2
· 2009
[cited by applicant]
WO WO2009147599A1
· 2009
[cited by applicant]
WO WO2010047834A1
· 2010
[cited by applicant]
WO WO2010067145A1
· 2010
[cited by applicant]
WO WO2010120823A2
· 2010
[cited by applicant]
WO WO2011044176A1
· 2011
[cited by applicant]
WO WO2011147546A1
· 2011
[cited by applicant]
WO WO2012082960A2
· 2012
[cited by applicant]
WO WO2012089588A1
· 2012
[cited by applicant]
WO WO2012116407A1
· 2012
[cited by applicant]
WO WO2012129574A2
· 2012
[cited by applicant]
WO WO2012150600A2
· 2012
[cited by applicant]
WO WO2012156051A1
· 2012
[cited by applicant]
WO WO2012156052A2
· 2012
[cited by applicant]
WO WO2013071307A1
· 2013
[cited by applicant]
WO WO2013192582A1
· 2013
[cited by applicant]
WO WO2014022215A1
· 2014
[cited by applicant]
WO WO2014107624A1
· 2014
[cited by applicant]
WO WO2014195516A1
· 2014
[cited by applicant]
WO WO2015036420A1
· 2015
[cited by applicant]
WO WO2015061663A1
· 2015
[cited by applicant]
WO WO2015143053A1
· 2015
[cited by applicant]
WO WO2017201525A1
· 2017
[cited by applicant]
Aston-Jones et al.; An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance; Annu. Rev. Neurosci .; 28: pp. 403-450; Jul. 21, 2005.
[cited by applicant]
Aston-Jones et al.; Role of locus coeruleus in attention and behavioral flexibility; Biological Psychiatry; 46(9); pp. 1309-1320; Nov. 1, 1999.
[cited by applicant]
Axelgaard Manufacturing Co. Ltd .; Little PALS® (product information); 2 pgs .; printed Feb. 11, 2013 from http://www.axelgaard.com/prod_little-pals.html.
[cited by applicant]
Axelgaard Manufacturing Co. Ltd .; PALS® Platinum Blue (product information); 2 pgs .; printed Feb. 11, 2013 from http://www.axelgaard.com/prod_pals-platinum-blue.html.
[cited by applicant]
Backhaus et al.; Sleep disturbances are correlated with decreased morning awakening salivary cortisol; Psychoneuroendocrinology; 29(9): pp. 1184-1191; Oct. 31, 2004.
[cited by applicant]
Basta et al.; Chronic Insomnia and the Stress System; Sleep Medicine Clinics; 2(2): pp. 279-291; (Author Manuscript, 20 pages); Jun. 30, 2007.
[cited by applicant]
Berlad et al.; Power spectrum analysis and heart rate variability in Stage 4 and REM sleep: evidence for state-specific changes in autonomic dominance; Journal of Sleep Research; 2(2): pp. 88-90; Jun. 1, 1993.
[cited by applicant]
Berridge et al.; The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes; Brain Research Reviews; 42(1); pp. 33-84; Apr. 30, 2003.
[cited by applicant]
Brown et al.; Control of sleep and wakefulness; Physiological reviews; 92(3); pp. 1087-1187; Jul. 1, 2012.
[cited by applicant]
Brown et al.; Locus ceruleus activation suppresses feedforward interneurons and reduces beta-gamma electroencephalogram frequencies while it enhances theta frequencies in rat dentate gyrus; Journals of Neuroscience; 25(…
[cited by applicant]
Buchanan et al.; Salivary alpha-amylase levels as a biomarker of experienced fear; Communicative and Integrative Biology; 3(6); pp. 525-527; Nov. 1, 2010.
[cited by applicant]
Buckley et al.; On the Interactions of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Sleep: Normal HPA Axis Activity and Circadian Rhythm, Exemplary Sleep Disorders; The Journal of Clinical Endocrinology and Metabol…
[cited by applicant]
Buysse et al.; The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research; Psychiatric Research; 28(2); pp. 193-213; May 31, 1989.
[cited by applicant]
Carter et al.; Tuning arousal with optogenetic modulation of locus coeruleus neurons; Nature Neuroscience; 13(12); pp. 1526-1533; Dec. 1, 2010.
[cited by applicant]
Chaieb et al.; Transcranial alternating current stimulation in the low kHz range increases motor cortex excitability; Restor Neurol Neurosci; 29(3); pp. 167-175; Mar. 2011.
[cited by applicant]
Cook et al.; Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study; Epilepsy and Behavior; 28(2): pp. 221-226; Aug. 31, 2013.
[cited by applicant]
Coutinho et al.; Musical emotions: predicting second-by-second subjective feelings of emotion from low-level psychoacoustic features and physiological measurements; Emotion; 11(4); pp. 921-937; Aug. 2011.
[cited by applicant]
DaSilva et al.; Electrode positioning and montage in transcranial direct current stimulation; J Vis Exp; 51; e2744; 11 pgs .; May 2011.
[cited by applicant]
Degiorgio et al., Trigeminal nerve stimulation for epilepsy: long-term feasibility and efficacy; Neurology; 72(10): pp. 936-938; Mar. 10, 2009.
[cited by applicant]
Degiorgio et al.; Randomized controlled trial of trigeminal nerve stimulation for drug-resistant epilepsy; Neurology; 80(9); pp. 786-791; Feb. 26, 2013.
[cited by applicant]
Digitimer Ltd.; DS2 and DS3 Isolated Stimulator (product information); 2 pgs.; downloaded from http://www.digitimer.com/research/stimulators/index.htm on Feb. 10, 2014.
[cited by applicant]
Elder et al.; The cortisol awakening response—applications and implications for sleep medicine; Sleep Medicine Reviews; 18(3): pp. 215-224; Jun. 30, 2014.
[cited by applicant]
Electozyme; Company and Product Information; 3 pgs.; printed Feb. 11, 2014 from http://electrozyme.com/applications/.
[cited by applicant]
Eschenko et al.; Noradrenergic neurons of the locus coeruleus are phase locked to cortical up-down states during sleep; Cerebral Cortex; 22(2); pp. 426-435; Feb. 1, 2012.
[cited by applicant]
Feurra et al.; Frequency specific modulation of human somatosensory cortex; Front Psychol; 2(13); 6 pgs.; Feburary 2011.
[cited by applicant]
Franowicz et al.; Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys; Neuropsychopharmacology; 21(5); pp. 611-621; Nov. 1, 1999.
[cited by applicant]
Garraway et al.; Modulatory actions of serotonin, norepinephrine, dopamine, and acetylcholine in spinal cord deep dorsal horn neurons; Journal of Neurophysiology; 86(5); pp. 2183-2194; Nov. 1, 2001.
[cited by applicant]
GoFLOW; tDCS Kit; product information; 9 pgs..; printed Feb. 10, 2014 (http://flowstateengaged.com/).
[cited by applicant]
Golestanirad et al; Analysis of fractal electrodes for efficient neural stimulation; Frontiers in Neurengineering; 6(3); 10 pages; Jul. 2013.
[cited by applicant]
Gracenote; Timeline-metadata-api; 3 pages; retrieved from the internet Jul. 7, 2015; (https://github.com/gracenote/timeline-metadata-api/blob/master/README.md).
[cited by applicant]
Granger et al.; Salivary alpha-amylase in biobehavioral research: recent developments and applications; Annals of the New York Academy of Sciences; 1098(1); pp. 122-144; Mar. 1, 2007.
[cited by applicant]
Grindhouse Wetware; Thinking Cap; product information; 1 pg.; printed Feb. 10, 2014 (http://www.grindhousewetware.com/thinkingcap.html).
[cited by applicant]
Gummadavelli et al.; Neurostimulation to improve level of consciousness in patients with epilepsy. Neurosurgical Focus; 38(6); pp. E10; (manuscript version, 14 pages); Jun. 2015.
[cited by applicant]
Hajos et al.; Norepinephrine but not serotonin reuptake inhibitors enhance theta and gamma activity of the septo-hippocampal system; Neuropsychopharmacology; 28(5); pp. 857-864; May 1, 2003.
[cited by applicant]
Hass et al.; Waking with the hypothalamus. Pflugers Arch R Eur. J. Physiol.; 463(1): pp. 31-42; Jan. 1, 2012.
[cited by applicant]
Herwig et al.; Intracortical excitability is modulated by a norepinephrine-reuptake inhibitor as measured with paired-pulse transcranial magnetic stimulation; Psychopharmacology (Berl): 164(2): pp. 228-232; Nov. 18, 200…
[cited by applicant]
Hirotsu et al.; Interactions between sleep, stress, and metabolism; From physiological to pathological conditions; Sleep Science; 8(3); pp. 143-152; Nov. 2015.
[cited by applicant]
Horvath et al.; Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: A systematic review; Neurop…
[cited by applicant]
Just et al.; Bold responses to trigeminal nerve stimulation; Magnetic Resonance Imaging; 28(8): pp. 1143-1151; Oct. 31, 2010.
[cited by applicant]
Kanai et al.; Frequency-dependent electrical stimulation of the visual cortex; Curr. Biol.; 18(23); pp. 1839-1843; Dec. 9, 2008.
[cited by applicant]
Kubota et al.; Role of the brain stem in cardiovascular changes induced by stimulation of the trigeminal nerve; Anesthesia Progress; 36(4-5); pp. 236-237; Jul. 1989.
[cited by applicant]
Lee et al.; Neuromodulation of Brain States; Neuron; 76(1): pp. 209-222. Oct. 4, 2012.
[cited by applicant]
Leproult et al.; Sleep loss results in an elevation of cortisol levels the next evening; Sleep; 20(10): pp. 865-870; Oct. 1997.
[cited by applicant]
Lovibond et al.; The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories; Behaviour Research and Therapy; 33(3); pp. 335-343…
[cited by applicant]
Lu et al.; A putative flip-flop switch for control of REM sleep; Nature; 441 (7093): pp. 589-594; Jun. 1, 2006.
[cited by applicant]
Magis et al.; Safety and patients' satisfaction of transcutaneous supraorbital neurostimulation (tSNS) with the Cefaly(R) device in headache treatment: a survey of 2,313 headache sufferers in the general population, The…
[cited by applicant]
McGough et al.; An eight-week, open-trial, pilot feasibility study of trigeminal nerve stimulation in youth with attention-deficit/hyperactivity disorder; Brain Stimulation; 8(2); pp. 299-304; Apr. 30, 2015.
[cited by applicant]
Meltzer et al; Direct comparison of two new actigraphs and polysomnography in children and adolescents; Sleep; 35(1); pp. 159-166; Jan. 1, 2012.
[cited by applicant]
Nash et al.; Differential activation of the human trigeminal nuclear complex by noxious and non-noxious orofacial stimulation; Human Brain Mapping; 30(11); pp. 3772-3782; Nov. 1, 2009.
[cited by applicant]
Nieuwenhuis et al.; Decision making, the P3, and the locus coeruleus-norepinephrine system; Psychological Bulletin; 131(4); pp. 510-532; Jul. 2005.
[cited by applicant]
Parvizi et al.; Consciousness and the brainstem; Cognition; 79(1): pp. 135-160; Apr. 30, 2001.
[cited by applicant]
Paulus, W.; Transcranial electrical stimulation (tES-tDCS; tRNS, tACS) methods; Neuropsychol Rehabil.; 21(5); pp. 602-617; Oct. 2011.
[cited by applicant]
Penzel et al.; Dynamics of Heart Rate and Sleep Stages in Normals and Patients with Sleep Apnea; Neuropsychopharmacology; 28(S1); pp. S48-S53; Jul. 1, 2003.
[cited by applicant]
Piquet et al.; Supraorbital transcutaneous neurostimulation has sedative effects in healthy subjects; BMC Neurology; 11(1); p. 135; (manual transcript, 8 pages); Oct. 28, 2011.
[cited by applicant]
Plewnia et al.; Enhancement of human cortico-motoneuronal excitability by the selective norepinephrine reuptake inhibitor reboxetine; Neuroscience Letters; 330(3); pp. 231-234; Sep. 27, 2002.
[cited by applicant]
Prausnitz; The effects of electric current applied to skin: a review for transdermal drug delivery; Advanced Drug Delivery Reviews; vol. 18; pp. 395-425; Feb. 8, 1996.
[cited by applicant]
Pusch et al.; Electrical stimulation of the vestibular system prevents postoperative nausea and vomiting: Acta Annesthesiol Scand.; 44(9); pp. 1145-1148; Oct. 2000.
[cited by applicant]
Riemann et al.; The hyperarousal model of insomnia: A review of the concept and its evidence; Sleep Medicine Reviews; 14(1); pp. 19-31; Feb. 28, 2010.
[cited by applicant]
Rill et al.; Pedunculopontine arousal system physiology—implications for insomnia; Sleep Science; 8(2); pp. 92-99; Jun. 30, 2015.
[cited by applicant]
Rohleder et al.; Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity; Annals of the New York Academy of Sciences; 1032(1); pp. 258-263; Dec. 1, 2004.
[cited by applicant]
Saiote et al.; High-frequency TRNS reduces BOLD activity during visuomotor learning; PLOS one; 8(3); e59669; 8 pgs.; Mar. 2013.
[cited by applicant]
Sara; The locus coeruleus and noradrenergic modulation of cognition; Nature Reviews Neuroscience; 10(3): pp. 211-223. Mar. 1, 2009.
[cited by applicant]
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