Heterocyclic inhibitors of MCT4
Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.
1 . A method for treating idiopathic pulmonary fibrosis in a subject in need thereof, comprising administering to the subject a compound of structural Formula VIII:
or a salt thereof, wherein:
L is chosen from a bond and methylene;
Y is chosen from
R 2c is chosen from H, C 1 -C 4 alkoxy and C 1 -C 4 cycloalkoxy;
R 2d is chosen from null and C 1 -C 4 alkoxy;
R 2e is C 1 -C 4 alkyl;
n is 1 or 2;
R 4 and R 5 are independently chosen from C 1 -C 3 alkyl; and
R 6 is chosen from H and C 1 -C 4 alkyl.
2 . The method as recited in claim 1 , wherein n is 1.
3 . The method as recited in claim 1 , wherein L is a bond.
4 . The method as recited in claim 1 , wherein Y is
5 . A method for treating idiopathic pulmonary fibrosis in a subject in need thereof, comprising administering to the subject a compound of structural Formula XI:
or a salt thereof, wherein:
W is chosen from
m is 1, 2, or 3;
L is chosen from a bond and methylene;
Z is chosen from
n is 1 or 2;
R 4 and R 5 are independently chosen from C 1 -C 3 alkyl;
R 6 is chosen from H and C 1 -C 4 alkyl; and
R 9 is chosen from halo, amino, and C 1 -C 4 alkoxy.
6 . The method as recited in claim 5 , wherein W is
7 . The method as recited in claim 5 , wherein L is a bond.
8 . The method as recited in claim 5 , wherein n is 1.
9 . A method for treating idiopathic pulmonary fibrosis in a subject in need thereof, comprising administering to the subject a compound of structural formula:
or a salt thereof.