Tumescent infiltration drug delivery of high subcutaneous drug concentrations with prolonged local and systemic effects and minimal local or systemic toxicity
A tumescent composition comprising a chemotherapy agent in a tumescent solution, wherein a tumescent concentration of the chemotherapy agent is simultaneously below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; and the tumescent solution comprises a vasoconstrictor; a pharmaceutically acceptable carrier; and optionally a local anesthetic.
1. A tumescent composition comprising a chemotherapy agent dissolved in a tumescent solution, wherein:
(a) a tumescent concentration of the chemotherapy agent is simultaneously:
1) Below a threshold for local, subcutaneous tissue toxicity,
2) above a threshold for positive local therapeutic effect, and
3) above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery;
(b) the tumescent solution comprises:
(i) a vasoconstrictor;
(ii) a pharmaceutically acceptable carrier; and
(iii) optionally a local anesthetic,
(c) the tumescent composition does not contain an antibiotic; and
(d) the chemotherapy agent is selected from the group consisting of an alkylating agent, an antimetabolite, an anti-tumor antibiotic, a topoisomerase inhibitor, a mitotic inhibitor, a corticosteroid, an angiogenesis inhibitor, actinomycin D, adriamycin, alkeran, ara-C, arsenic trioxide (trisenox), avastin, BiCNU, busulfan, carboplatinum, CCNU, cisplatinum, cytoxan, daunorubicin, DTIC, 5-FU, erlotinib, fludarabine, gemcitabine, herceptin, hydrea, idarubicin, ifosfamide, irinotecan, lapatinib, leustatin, 6-MP, methotrexate, mithramycin, mitomycin, mitoxantrone, navelbine, nitrogen mustard, rituxan, 6-TG, taxol, taxotere, topotecan, velban, vincristine, VP-16, and xeloda.
2. The tumescent composition of claim 1 , wherein said optional local anesthetic is lidocaine.
3. The tumescent composition of claim 2 , wherein the concentration of lidocaine is approximately 100 mg to 1,500 mg per L of solution.
4. A tumescent composition comprising a chemotherapy agent dissolved in a tumescent solution, wherein:
(a) a tumescent concentration of the chemotherapy agent is simultaneously:
1) Below a threshold for local, subcutaneous tissue toxicity,
2) above a threshold for positive local therapeutic effect, and
3) above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery;
(b) the tumescent solution comprises:
(i) a vasoconstrictor;
(ii) a pharmaceutically acceptable carrier; and
(iii) optionally a local anesthetic,
(c) the tumescent composition does not contain an antibiotic; and
(d) said tumescent composition further comprises an anti-inflammatory agent.
5. The tumescent composition of claim 1 , wherein said vasoconstrictor comprises epinephrine.
6. The tumescent composition of claim 5 wherein the concentration of epinephrine is approximately 0.2 to 1.5 mg/L.
7. The tumescent composition of claim 1 , wherein said tumescent composition further comprises an agent that reduces neuropathic pain or the risk of developing neuropathic pain.
8. A method of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject the tumescent composition according to claim 1 .
9. The method of claim 8 , wherein infiltration of the tumescent composition achieves both prolonged local drug concentration within a tumescent subcutaneous tissue as well as a prolonged slow constant systemic absorption of drugs from the tumescent tissue into a systemic circulation.
10. The method of claim 8 , wherein a pharmacokinetic profile of the systemic absorption resembles a slow, constant, intravenous (IV) infusion.
11. The method of claim 8 , wherein the subcutaneous concentration of the drug or therapeutic agent achieved is from about 1-100 times the maximum subcutaneous interstitial fluid concentration that can be achieved by conventional IV, IM or oral delivery of the drug or therapeutic agent.
12. The method of claim 8 , wherein local and systemic blood viscosity are reduced in the subject and local and systemic oxygenation of tissues in the subject is increased.
13. The method of claim 8 , wherein said tumescent composition comprises an agent that reduces neuropathic pain or the risk of developing neuropathic pain from a cancer.
14. The method of claim 8 , wherein the method treats a localized cancer.
15. The method of claim 14 , wherein the localized cancer is selected from the group consisting of skin cancer, breast cancer, lymphoma, Pancreatic Adenocarcinoma, Insulinoma, lung cancer, colon cancer, prostate cancer, ovarian cancer and a metastatic cancer.
16. The method of claim 15 , wherein said skin cancer is a malignant or benign skin tumor selected from the group consisting of Basal Cell Carcinoma, Squamous Cell Carcinoma, melanoma, Merkel Cell Carcinoma, Kaposi's Sarcoma, Lymphoma of the Skin and Soft Tissue Cancer.
17. A method of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject the tumescent composition according to claim 4 .
18. The method of claim 17 , wherein said tumescent composition further comprises an agent that reduces neuropathic pain or the risk of developing neuropathic pain from a cancer.
19. The method of claim 17 , wherein the method treats a localized cancer.
20. The method of claim 19 , wherein the localized cancer is selected from the group consisting of skin cancer, breast cancer, lymphoma, Pancreatic Adenocarcinoma, Insulinoma, lung cancer, colon cancer, prostate cancer, ovarian cancer and a metastatic cancer.
21. The method of claim 20 , wherein said skin cancer is a malignant or benign skin tumor selected from the group consisting of Basal Cell Carcinoma, Squamous Cell Carcinoma, melanoma, Merkel Cell Carcinoma, Kaposi's Sarcoma, Lymphoma of the Skin and Soft Tissue Cancer.