Uses of indolinone compounds
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
1. A pharmaceutical composition for combination therapy, comprising:
at least one therapeutic agent selected from the group consisting of rituximab, bendamustine, ibrutinib, idelalisib, birabresib, bimiralisib, selinexor, and ACP196; and
a compound having a structure:
or a stereoisomer, a pharmaceutically acceptable salt, or solvate thereof.
2. The pharmaceutical composition for combination therapy of claim 1 , wherein the compound has a structure:
3. The pharmaceutical composition for combination therapy of claim 1 , wherein the compound has a structure:
4. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is rituximab.
5. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is bendamustine.
6. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is ibrutinib.
7. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is idelalisib.
8. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is birabresib.
9. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is bimiralisib.
10. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is selinexor.
11. The pharmaceutical combination of claim 1 , wherein the at least one therapeutic agent is ACP196.
12. A method for inducing apoptosis in a cell comprising a myeloblast produced in acute myeloid leukemia or a lymphocyte produced in diffuse large B cell lymphoma, comprising contacting the cell with an effective amount of a combination of:
at least one therapeutic agent selected from the group consisting of rituximab, bendamustine, ibrutinib, idelalisib, birabresib, bimiralisib, selinexor, and ACP196; and
a compound having a structure:
or a stereoisomer, a pharmaceutically acceptable salt, or solvate thereof.
13. The method of claim 12 , wherein the compound has a structure:
14. The method of claim 12 , wherein the compound has a structure:
15. The method of claim 12 , wherein the cell is a myeloblast produced in acute myeloid leukemia.
16. The method of claim 12 , wherein the cell is a lymphocyte produced in diffuse large B cell lymphoma.
17. The method of claim 12 , wherein the at least one therapeutic agent is rituximab.
18. The method of claim 12 , wherein the at least one therapeutic agent is bendamustine.
19. The method of claim 12 , wherein the at least one therapeutic agent is ibrutinib.
20. The method of claim 12 , wherein the at least one therapeutic agent is idelalisib.