IP Library › Granted Patent US 12,337,180
Granted Patent B2
US 12,337,180 · App. 17/706,378 · Granted Jun 24, 2025

Apparatus for brain stimulation

Inventors: Sara Renata Francesca Marceglia (La Spezia, IT); Alberto Priori (Virgilio, IT); Mattia Arlotti (Monza Brianza, IT)
Assignee: Newronika S.p.A.
A61N1/36082A61N1/0534A61N1/36135A61N1/36171A61N1/36175A61N1/36178
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Quick Facts
Patent No.
US 12,337,180
App. No.
17/706,378
Granted
Jun 24, 2025
Kind
B2
Abstract

Disclosed herein are deep-brain stimulation (DBS) systems and methods for the treatment of Tourette Syndrome (TS). The DBS methods described herein comprise a stimulation paradigm that may help to reduce the frequency and/or severity of motor and vocal tics, as well as rapid and involuntary muscle motions that are characteristic of TS. One variation of a method for the treatment of TS comprises adjusting electrical stimulation to a target brain region based on changes or variations in the neural activity signals in the target brain region. One example of a method described herein comprises monitoring the power values (e.g., spectral power values) of one or more frequency bands of the acquired neural activity signals and adjusting electrical stimulation parameters based on at least one variation or change of the monitored power values.

Claims (21)

1. An apparatus comprising:

an implantable probe comprising an electrode configured for brain implantation; and

a stimulation device in communication with the implantable probe, wherein the stimulation device comprises:

an acquisition module in electrical communication with the implantable probe to acquire a neural activity signal from the electrode, and configured to be responsive to an acquisition processor to:

detect a decrease of a first power of the acquired neural activity signal in a first frequency band with respect to a first baseline value for a first predetermined duration followed by an increase in the first power with respect to the first baseline value for a second predetermined duration, and

modify an electrical stimulation parameter if the decrease followed by the increase of the first power of the acquired neural activity signal is detected; and

a stimulation module having a voltage source or current source configured to generate and transmit to the electrode a stimulation signal in accordance with the modified electrical stimulation parameter.

2. The apparatus of claim 1 , wherein the detecting the further comprises determining whether a second power of the acquired neural activity signal in a second frequency band increases for a third predetermined duration with respect to a second baseline value simultaneously with the decrease of the first power.

3. Apparatus of claim 2 , wherein the second frequency band comprises frequencies in the low-frequency band (about 2 Hz to about 7 Hz).

4. The apparatus of claim 1 , wherein the first predetermined duration is at least 250 ms, and the second predetermined duration is at least 250 ms.

5. The apparatus of claim 1 , wherein the increase in the first power is at least 2.5 times greater than the first baseline value.

6. The apparatus of claim 1 , wherein the decrease of the first power is at least 20% below the first baseline value and the following increase of the first power is at least 150% above the first baseline value.

7. The apparatus of claim 1 , wherein the first frequency band comprises frequencies in the alpha band (about 8 Hz to about 12 Hz).

8. The apparatus of claim 1 , wherein the electrical stimulation parameter is an electrical pulse frequency, and modifying the parameter comprises assigning the electrical pulse frequency to a frequency that is from about 30 Hz to about 40 Hz.

9. The apparatus of claim 1 , wherein the electrical stimulation parameter is an electrical pulse frequency, and the initial electrical stimulation parameter is an initial electrical pulse frequency value, and modifying the parameter value comprises assigning the electrical pulse frequency to a frequency value that is about 50% less than the initial electrical pulse frequency value.

10. The apparatus of claim 1 , wherein the electrical stimulation parameter is an electrical pulse width value, and modifying the parameter value comprises assigning the electrical pulse width to a width value from about 10 us to about 30 μs.

11. The apparatus of claim 1 , wherein the acquisition module is further configured to be responsive to the acquisition processor to:

determining whether the first power has returned to approximately the first baseline value, and

reverting the modified electrical stimulation parameter to an initial electrical stimulation parameter if the first power has returned to approximately the first baseline value.

12. The apparatus of claim 11 , wherein the modified electrical stimulation parameter is reverted to the initial electrical stimulation parameter if the first power has returned to within about 50% of the first baseline value.

13. The apparatus of claim 1 , wherein the acquisition module circuitry comprises a band pass filter, a rectifier, and an average filter for determining the first power of the acquired neural activity signal in the first frequency band.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2022
From: MARCEGLIA, SARA RENATA FRANCESCA; PRIORI, ALBERTO; ARLOTTI, MATTIA
To: NEWRONIKA S.P.A.
Reel/Frame 060288/0225 →
Continuity (3)
Continuation 16706552 · Dec 6, 2019
Provisional Application 62779216 · Dec 13, 2018
Related Publication 20220323762A1 · Oct 13, 2022
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