Bioprocess vessels with integrated pump
A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.
1. A bioprocess vessel having an integrated pump comprising:
a flexible bag defining an interior volume and having a bottom surface, the bottom surface containing an aperture therein for the passage of fluid;
a port disposed in the aperture and secured to the bottom surface of the flexible bag; and
a pump head and having an inlet and an outlet, the pump head having a flanged end that is secured to the port and further including a plurality of diaphragms, each diaphragm associated with a check-valve, wherein sequential actuation of the plurality of diaphragms pumps fluid from the interior volume of the flexible bag into the inlet and out of the outlet.
2. The bioprocess vessel of claim 1 , wherein the port comprises a flanged end and wherein the flanged end of the pump head is secured to the flanged end of the port.
3. The bioprocess vessel of claim 1 , further comprising a mixing adapter secured to the pump head and disposed at least partially in the interior volume of the flexible bag, the mixing adapter at least partially covering the inlet of the pump head.
4. The bioprocess vessel of claim 1 , the pump head further comprising a nutating disk or wobble plate configured to sequentially actuate the plurality of diaphragms.
5. The bioprocess vessel of claim 4 , further comprising a detachable motor secured to the pump head.
6. The bioprocess vessel of claim 1 , further comprising a plurality of actuators configured to sequentially actuate the plurality of diaphragms.
7. A bioprocess vessel having an integrated pump comprising:
a substantially rigid container formed from a resin or polymer material defining an interior volume and having a bottom surface; and
a port disposed in the bottom surface of the substantially rigid container; and
a pump head and having an inlet and an outlet, the pump head having a flanged end that is secured to the port and further including a plurality of diaphragms, each diaphragm associated with a check-valve, wherein sequential actuation of the plurality of diaphragms pumps fluid from the interior volume of the substantially rigid container into the inlet and out of the outlet.
8. The bioprocess vessel of claim 7 , wherein the port comprises a flanged end and wherein the flanged end of the pump head is secured to the flanged end of the port.
9. The bioprocess vessel of claim 7 , further comprising a mixing adapter secured to the pump head and disposed at least partially in the interior volume of the substantially rigid container, the mixing adapter at least partially covering the inlet of the pump head.
10. The bioprocess vessel of claim 7 , the pump head further comprising a nutating disk or wobble plate configured to sequentially actuate the plurality of diaphragms.
11. The bioprocess vessel having an integrated pump of claim 10 , further comprising a detachable motor secured to the pump head.
12. The bioprocess vessel of claim 7 , further comprising a plurality of actuators configured to sequentially actuate the plurality of diaphragms.
13. The bioprocess vessel of claim 7 , further comprising a lid having one or more ports formed therein.
14. The bioprocess vessel of claim 13 , further comprising a rotating shaft extending through the lid and into the interior of the substantially rigid container and having an impeller thereon.