Granted Patent
B2
US 12,403,109 · App. 17/725,189 · Granted Sep 2, 2025
Sotalol hydrochloride dosing
Inventors:
John Somberg (Chicago, IL); Brandon Ira Kashfian (Chicago, IL); Janos Molnar (Chicago, IL)
Assignee:
AltaThera Pharmaceuticals LLC
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Abstract
The present invention provides novel methods of administering sotalol hydrochloride to patients in need thereof.
Claims (14)
1. A method of administering sotalol hydrochloride, comprising:
a. administering an intravenous (IV) dose of 125-135 mg sotalol hydrochloride over a period of 1 hour to a subject having had symptomatic atrial fibrillation or atrial flutter, wherein the subject is currently in sinus rhythm; and
b. after completion of the IV dose, administering oral dosing of one or more oral dose of sotalol hydrochloride to the subject in an amount of 120 mg.
2. The method of claim 1 , wherein the oral dosing is initiated 4-12 hours after completion of the IV dose.
3. The method of claim 1 , wherein one or more of the oral doses are administered at a 12-48 hour interval from initiation of the oral dosing.
4. The method of claim 3 , wherein:
the oral dosing is initiated 4-6 hours after completion of the IV dose; and
one or more of the oral doses are administered at a 12-24 hour interval from initiation of the oral dosing.
5. The method of claim 3 , wherein the oral dosing is initiated 4-12 hours after completion of the IV dose.
6. The method of claim 2 , wherein:
the oral dosing is initiated 4-6 hours after completion of the IV dose; and
one or more of the oral doses are administered at a 12-48 hour interval from initiation of the oral dosing.
7. The method of claim 6 , wherein:
one or more of the oral doses are administered at a 12 hour interval from initiation of the oral dosing.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 29, 2022
From: SOMBERG, JOHN CHARIN; KASHFIAN, BRANDON IRA; MOLNAR, JANOS
To: ALTATHERA PHARMACEUTICALS LLC
Reel/Frame 059825/0868 →
Continuity (10)
Continuation In Part
16103815
· Aug 14, 2018
Continuation
16103815
· Aug 14, 2018
Continuation In Part
16849099
· Apr 15, 2020
Provisional Application
63009511
· Apr 14, 2020
Provisional Application
62987832
· Mar 10, 2020
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