Method for preparing N-[4-(2-{[2-(4-methane sulfonamidophenoxy) ethyl] (methyl)amino}ethyl)phenyl]methanesulfonamide (dofetilide)
A method for preparing 1-(4-methanesulfonamidophenoxy)-2-[N-(4-methanesulfonamidophenethyl)-N-methylamino]ethane (Dofetilide) of formula I by sulfonylation of 1-(4-aminophenoxy)-2-[N-(4-aminophenethyl)-N-methylamino]ethane of formula II with N-methylsulfonyl-N′-methylimidazolium chloride of formula III.
1. A method for preparing 1-(4-methanesulfonamidophenoxy)-2-[N-(4-methane-sulfonamidophenethyl)-N-methylamino]ethane (Dofetilide) of formula I
by sulfonylation of 1-(4-aminophenoxy)-2-[N-(4-aminophenethyl)-N-methylamino]ethane of formula II,
characterized in that the sulfonylation is carried out with N-methylsulfonyl-N′-methylimidazolium chloride of formula III
in an organic solvent.
2. The method according to claim 1 , characterized in that N-methylsulfonyl-N′-methylimidazolium chloride prepared by reaction of 1-methylimidazole with methanesulfonyl chloride is used.
3. The method according to claim 1 , characterized in that the organic solvent is N-methylpyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide or their mixture.
4. The method according to claim 1 , characterized in that the reaction is carried out at a temperature of −20 to −5° C.