IP Library › Granted Patent US 11,672,789
Granted Patent B2
US 11,672,789 · App. 17/728,485 · Granted Jun 13, 2023

Radiation mitigator and method of use thereof

Inventors: Milton L. Brown (Brookeville, MD); Yali Kong (Fairfax, VA); Courtney Houchen (Edmond, OK); Sripathi M. Sureban (Oklahoma City, OK); Parthasarathy Chandrakesan (Edmond, OK)
Assignees: Georgetown University; The Board of Regents of the University of Oklahoma
A61K31/454A61K31/4184A61P39/00
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Quick Facts
Patent No.
US 11,672,789
App. No.
17/728,485
Granted
Jun 13, 2023
Kind
B2
Abstract

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

Claims (20)

1. A method for treating or preventing radiation-induced tissue injury, comprising co-administering to a subject in need thereof a therapeutically effective amount of a compound represented by formula II

or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of a compound represented by formula III

or a pharmaceutically acceptable salt thereof, thereby treating or preventing radiation-induced tissue injury in the subject.

2. The method of claim 1 , wherein the compounds are co-administered prior to exposure of the subject to radiation.

3. The method of claim 1 , wherein the compounds are co-administered after exposure of the subject to radiation.

4. The method of claim 1 , wherein the radiation-induced tissue injury is acute radiation-induced tissue injury.

5. The method of claim 1 , wherein the radiation-induced tissue injury is chronic radiation-induced tissue injury.

6. The method of claim 2 , wherein the radiation-induced tissue injury is acute radiation-induced tissue injury.

7. The method of claim 2 , wherein the radiation-induced tissue injury is chronic radiation-induced tissue injury.

8. The method of claim 3 , wherein the radiation-induced tissue injury is acute radiation-induced tissue injury.

9. The method of claim 3 , wherein the radiation-induced tissue injury is chronic radiation-induced tissue injury.

10. The method of claim 1 , wherein the tissue comprises gastrointestinal tissue.

11. The method of claim 1 , wherein the tissue comprises hematopoietic tissue.

12. The method of claim 1 , wherein the tissue comprises neural tissue.

13. The method of claim 1 , wherein the compound is administered orally.

14. The method of claim 1 , wherein the compound is administered parenterally.

15. The method of claim 1 , wherein the subject is a mammal.

16. The method of claim 1 , wherein the subject is a human.

17. The method of claim 1 , wherein the radiation-induced tissue injury is prevented.

18. The method of claim 1 , wherein the radiation-induced tissue injury is treated.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2023
From: BROWN, MILTON L.; KONG, YALI
To: GEORGETOWN UNIVERSITY
Reel/Frame 063464/0013 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2023
From: HOUCHEN, COURTNEY W.; SUREBAN, SRIPATHI M.; CHANDRAKESAN, PARTHASARATHY
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Reel/Frame 063464/0084 →
Continuity (3)
Continuation 16089794
Provisional Application 62316121 · Mar 31, 2016
Related Publication 20230033749A1 · Feb 2, 2023
Cited By (1)
US 12,246,011