Patent
The present invention generally relates to the field of probiotic bacteria. In particular, it relates to methods for treating or preventing functional GI disorders comprising administering Bifidobacterium longum , such as Bifidobacterium longum ATCC BAA-999.
1. A method for treatment of irritable bowel syndrome and anxiety in a subject in need thereof, the method comprising:
administering to the subject a composition comprising Bifidobacterium longum ATCC BAA-999 and a B vitamin,
wherein the composition is selected from the group consisting of a dietary supplement, a nutraceutical, a drink, and a medical composition.
2. The method of claim 1 , wherein the composition comprises at least one other type of food grade bacteria.
3. The method of claim 2 , wherein the at least one other type of food grade bacteria is selected from the group consisting of lactic acid bacteria and propionibacteria.
4. The method of claim 1 , wherein the composition comprises at least one prebiotic.
5. The method of claim 4 , wherein the at least one prebiotic is selected from the group consisting of oligosaccharides and dietary fibers.
6. The method of claim 1 , wherein at least 5% of Bifidobacterium longum ATCC BAA-999 cells are viable in the composition.
7. The method of claim 1 , wherein at least 80% of Bifidobacterium longum ATCC BAA-999 cells are non-replicating in the composition.
8. The method of claim 1 , wherein the composition comprises between 10 4 and 10 10 cells of Bifidobacterium longum ATCC BAA-999 per daily dose.
9. The method of claim 1 , wherein the composition comprises between 10 2 and 10 8 cells of Bifidobacterium longum ATCC BAA-999 per g dry weight of the composition.
10. The method of claim 1 , wherein the composition comprises a protein source comprising hydrolyzed whey protein.
11. The method of claim 1 , wherein the composition is in powder form having a water activity of less than 0.2.
12. The method of claim 1 , wherein the B vitamin is selected from the group consisting of Vitamin B1, Vitamin B6, Vitamin B2, niacin, Vitamin B12, folic acid, biotin, and mixtures thereof.
13. The method of claim 1 , wherein the composition comprises at least one of 1 to 2 mg Vitamin B1, 0.5 to 1.5 mg Vitamin B6, 0.5 to 2 mg Vitamin B2, 5 to 18 mg niacin, 0.5 to 2.0 μg Vitamin B12, 100 to 800 μg folic acid, or 30 to 70 μg biotin.
14. The method of claim 1 , wherein the composition further comprises at least one of a protein, a fat source, and a source of carbohydrates.
15. The method of claim 14 , wherein the composition further comprises at least one of 5 wt. % to 40 wt. % of a fat source and 40 wt. % to 80 wt. % of a source of carbohydrates.