IP Library › Granted Patent US 12,605,070
Granted Patent B2
US 12,605,070 · App. 17/804,645 · Granted Apr 21, 2026

System and method for determining segments for ablation

Inventors: Clifford Robinson (St. Louis, MO); Phillip Cuculich (St. Louis, MO); Geoffrey Hugo (St. Louis, MO)
Assignee: Washington University
A61B5/0036A61B5/0035A61B5/0044A61B5/055A61B5/364A61B5/7275A61B6/032A61B6/037A61B8/14G16H10/60
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Quick Facts
Patent No.
US 12,605,070
App. No.
17/804,645
Granted
Apr 21, 2026
Kind
B2
Abstract

A method for selecting one or more targets for non-invasively treating a cardiac arrhythmia in a patient includes receiving a mapping associated with the patient's heart and generating a segmented model of the mapping associated with the patient's heart. The segmented model divides the mapping into a plurality of segments. The method includes identifying one or more abnormality in the segmented model of the mapping associated with the patient's heart, determining which segment or segments of the plurality of segments include the identified one or more abnormality, and selecting a target for non-invasive treatment of the cardiac arrhythmia based on the determined segment or segments of the plurality of segments that include the identified one or more abnormality.

Claims (22)

1 . A method for selecting one or more targets and non-invasively treating a cardiac arrhythmia in a heart of a patient, the method comprising:

receiving a plurality of mappings associated with the patient's heart;

identifying one or more abnormality in the received plurality of mappings associated with the patient's heart;

providing a two-dimensional (2D) segmented model of the patient's heart for each mapping of the plurality of mappings, each 2D segmented model including a plurality of segments, wherein the plurality of segments is a predetermined number of segments each corresponding to a different portion of the patient's heart;

determining which segment or segments of the plurality of segments of each of the 2D segmented models include the identified one or more abnormality;

combining the 2D segmented models;

generating a three dimensional (3D) segmented model of the combined 2D segmented models including the determined segment or segments of the plurality of segments;

overlaying the generated 3D segmented model on a 3D image of the patient's heart;

selecting a target for non-invasive treatment of the cardiac arrhythmia based on the determined segment or segments of the plurality of segments; and

non-invasively treating the cardiac arrythmia by directing therapy at the selected target for ablation.

2 . The method of claim 1 , wherein non-invasively treating the cardiac arrythmia comprises performing non-invasive ablation by one or more of stereotactic body radiotherapy, stereotactic ablative radiotherapy, stereotactic radiosurgery, fractionated radiotherapy, or hypofractionated radiotherapy.

3 . The method claim 1 , wherein non-invasively treating the cardiac arrythmia by directing therapy at the selected target for ablation comprises outputting the selected target for ablation to a non-invasive treatment system and non-invasively treating the cardiac arrythmia by directing therapy at the selected target for ablation using the non-invasive treatment system.

4 . The method of claim 1 , wherein the 2D segmented model comprises a seventeen segment model in which the plurality of segments consists of seventeen segments.

5 . The method of claim 1 , wherein selecting a target for non-invasive treatment of the cardiac arrhythmia based on the determined segment or segments of the plurality of segments in the plurality of 2D segmented models comprises selecting as a target for non-invasive treatment of the cardiac arrhythmia any segment in the 3D model that is determined to include the identified one or more abnormality from more than one 2D segmented model of the plurality of 2D segmented models.

6 . The method of claim 1 , wherein selecting a target for non-invasive treatment of the cardiac arrhythmia based on the determined segment or segments of the plurality of segments in the plurality of 2D segmented models comprises selecting a target for non-invasive treatment of the cardiac arrhythmia based on how many 2D segmented models of the plurality of segmented models include the identified one or more abnormality in a same segment of the plurality of segments.

7 . The method of claim 1 , wherein the mappings of the plurality of mappings are selected from an electrical mapping, an anatomic mapping, a functional mapping, and combinations thereof.

8 . The method of claim 7 , wherein the electrical mapping comprises an electrocardiograph image, the anatomic mapping comprises one or more of a computer tomography image or a magnetic resonance image, and the functional mapping comprises one or more of a photon emission computed tomographic image, a positron emission tomography image or an echocardiogram image.

9 . The method of claim 1 , wherein determining which segment or segments of the plurality of segments of the 2D segmented model include the identified one or more abnormality comprises receiving a manual identification of the segment or segments of the plurality of segments of the 2D segmented model.

10 . The method of claim 1 , wherein determining which segment or segments of the plurality of segments of the 2D segmented model include one or more abnormality comprises automatically detecting the segment or segments of the plurality of segments of the 2D segmented model that include one or more abnormality.

11 . A non-transitory computer readable medium storing instructions which when executed by at least one processor, cause the at least one processor to non-invasively treat a cardiac arrhythmia in a patient by: receiving a plurality of mappings associated with the patient's heart; identifying one or more abnormality in the received plurality of mappings associated with the patient's heart; providing a two-dimensional (2D) segmented model of the patient's heart for each mapping of the plurality of mappings, each 2D segmented model including a plurality of segments, wherein the plurality of segments is a predetermined number of segments each corresponding to a different portion of the patient's heart; determining which segment or segments of the plurality of segments of each of the 2D segmented models include the identified one or more abnormality; combining the 2D segmented models; generating a three dimensional (3D) segmented model of the combined 2D segmented models including the determined segment or segments of the plurality of segments; overlaying the generated 3D segmented model on a 3D image of the patient's heart; selecting a target for non-invasive treatment of the cardiac arrhythmia based on the determined segment or segments of the plurality of segments that include the identified one or more abnormality; and directing non-invasive therapy at the selected target for ablation.

12 . The non-transitory computer readable medium of claim 11 , wherein the instructions cause the processor to direct non-invasive therapy at the selected target for ablation by outputting the selected target for ablation to a non-invasive treatment system for directing therapy at the selected target for ablation using the non-invasive treatment system.

13 . The non-transitory computer readable medium of claim 11 , wherein the 2D segmented model comprises a seventeen segment model in which the plurality of segments consists of seventeen segments.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2022
From: ROBINSON, CLIFFORD; CUCULICH, PHILLIP; HUGO, GEOFFREY
To: WASHINGTON UNIVERSITY
Reel/Frame 060057/0945 →
Continuity (4)
Continuation 16771981
Provisional Application 62607084 · Dec 18, 2017
Provisional Application 62598162 · Dec 13, 2017
Related Publication 20220369930A1 · Nov 24, 2022
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