IP Library › Granted Patent US 12,285,263
Granted Patent B2
US 12,285,263 · App. 17/804,846 · Granted Apr 29, 2025

Assessing neural state from action potentials

Inventor: John Louis Parker (Artarmon, AU)
Assignee: Saluda Medical Pty Ltd
A61B5/4076A61B5/388A61B5/4041A61B5/407A61B5/4824A61B5/4836A61N1/36071A61N1/36135A61N1/36185
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Quick Facts
Patent No.
US 12,285,263
App. No.
17/804,846
Granted
Apr 29, 2025
Kind
B2
Abstract

The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.

Claims (42)

1. A method of assessing a neural state of a subject, the method comprising:

obtaining a recording of a compound action potential arising in neural tissue of the subject from one or more implanted sense electrodes of an implantable neurostimulator;

providing to a processor of a control device the recording of the compound action potential;

processing, by the processor, the recording to detect an anomaly in a profile of the recorded compound action potential by determining whether a peak in the recorded compound action potential has an atypically swift rate of rise;

generating, by the processor, an indication regarding the neural state of the subject based on detected anomalies in the recorded compound action potential;

outputting, by the processor, the indication regarding the neural state of the subject; and

configuring, by the processor, the implantable neurostimulator using the indication regarding the neural state of the subject.

2. The method of claim 1 wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises determining whether more than three peaks exist in the recorded compound action potential.

3. The method of claim 1 wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises determining whether a peak in the recorded compound action potential is unexpectedly broad.

4. The method of claim 1 wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises determining whether anomalous frequency components exist in the recorded compound action potential when assessed in the frequency domain.

5. The method of claim 1 wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises:

determining a degree of deviation of the profile of the recorded compound action potential from a predefined expected compound action potential profile; and

comparing the degree of deviation with a predetermined threshold.

6. The method of claim 1 wherein the detection of an anomaly in the profile of the recorded compound action potential comprises identifying a locus of neuropathic pain by applying stimuli to first and second neural sites and determining which stimulus gives rise to greatest anomalies in a recorded compound action potential profile.

7. The method of claim 1 wherein configuring the implantable neurostimulator is performed intra-operatively to effect electrode array implantation site optimisation.

8. The method of claim 1 wherein configuring the implantable neurostimulator is performed during a programming stage in order to optimise electrode selection.

9. The method of claim 1 wherein configuring the implantable neurostimulator is performed intra-operatively during a sympathectomy procedure, in order to provide an intra-operative progressive indication of efficacy of the sympathectomy.

10. The method of claim 1 , further comprising administering or modifying a therapy in a manner responsive to the indication regarding the neural state of the subject.

11. A neural state measurement system, comprising:

an implantable neurostimulator, comprising:

at least one implantable sense electrode;

a telemetry module;

a module controller; and

a memory, where the memory comprises a control program capable of directing a processor to:

obtain a recording of a compound action potential arising in neural tissue of a subject using the at least one implantable sense electrode; and

provide the recording of the compound action potential to a processor of a control device; and

the control device, where the processor of the control device is configured to:

process the recording to detect an anomaly in a profile of the recorded compound action potential by determining whether a peak in the recorded compound action potential has an atypically swift rate of rise;

generate, based on detected anomalies in the recorded compound action potential, an indication regarding the neural state of the subject;

output the indication regarding the neural state of the subject; and

configure the implantable neurostimulator using the indication regarding the neural state of the subject.

12. The neural state measurement system of claim 11 , wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises determining whether more than three peaks exist in the recorded compound action potential.

13. The neural state measurement system of claim 11 , wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises determining whether a peak in the recorded compound action potential is unexpectedly broad.

14. The neural state measurement system of claim 11 , wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises determining whether anomalous frequency components exist in the recorded compound action potential when assessed in the frequency domain.

15. The neural state measurement system of claim 11 , wherein the detection of an anomaly in the profile of the recorded compound action potential further comprises:

determining a degree of deviation of the profile of the recorded compound action potential from a predefined expected compound action potential profile; and

comparing the degree of deviation with a predetermined threshold.

16. The neural state measurement system of claim 11 wherein the detection of an anomaly in the profile of the recorded compound action potential comprises identifying a locus of neuropathic pain by applying stimuli to first and second neural sites and determining which stimulus gives rise to greatest anomalies in a recorded compound action potential profile.

17. The neural state measurement system of claim 11 , wherein configuring the implantable neurostimulator is performed intra-operatively to effect electrode array implantation site optimisation.

18. The neural state measurement system of claim 11 , wherein configuring the implantable neurostimulator is performed during a programming stage in order to optimise electrode selection.

19. The neural state measurement system of claim 11 , wherein configuring the implantable neurostimulator is performed intra-operatively during a sympathectomy procedure, in order to provide an intra-operative progressive indication of efficacy of the sympathectomy.

20. The neural state measurement system of claim 11 , wherein the processor of the control device is further configured to administer or modify a therapy in a manner responsive to the indication regarding the neural state of the subject.

Assignments (2)
SECURITY INTEREST Recorded Mar 14, 2025
From: SALUDA MEDICAL PTY LTD
To: PERCEPTIVE CREDIT HOLDINGS IV, LP
Reel/Frame 070518/0710 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2022
From: PARKER, JOHN LOUIS
To: SALUDA MEDICAL PTY LTD
Reel/Frame 061220/0361 →
Priority Claims (1)
AU 2014901110 · Mar 28, 2014 · national
Continuity (2)
Continuation 15129407
Related Publication 20220287620A1 · Sep 15, 2022
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