Granted Patent
B2
US 12,478,503 · App. 17/822,716 · Granted Nov 25, 2025
Implants with controlled drug delivery features and methods of using same
Inventors:
David S. Haffner (Mission Viejo, CA); Thomas W. Burns (Dana Point, CA); Harold A. Heitzmann (Irvine, CA); Kenneth M. Curry (Oceanside, CA)
Assignee:
Glaukos Corporation
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Claims (29)
1 . A drug delivery ocular implant comprising:
an outer shell having a proximal end and a distal end, the outer shell being shaped to define an at least partially enclosed space;
a drug positioned within the at least partially enclosed space;
a cap having compressible regions configured to seal the cap to the proximal end of the outer shell;
a permeable or semi-permeable material positioned between the cap and the proximal end of the outer shell; and
at least one fluid inflow pathway and one fluid outflow pathway positioned adjacent the distal end of the outer shell,
wherein the at least one fluid inflow pathway and one fluid outflow pathway are configured to deliver ocular fluid to a physiological outflow pathway.
2 . The implant of claim 1 , wherein the cap is a crimp cap.
3 . The implant of claim 1 , wherein the cap extends toward the distal end of the outer shell and encloses only a portion of the outer shell.
4 . The implant of claim 1 , further comprising a retention feature configured to anchor the implant in place.
5 . The implant of claim 1 , wherein the permeable or semi-permeable material has a thickness of between about 50 and about 100 microns.
6 . The implant of claim 5 , wherein the drug elutes from the drug delivery ocular implant for a period of time ranging from about 12 to about 24 months.
7 . The implant of claim 1 , wherein the permeable or semi-permeable material has a thickness of between about 90 and about 200 microns.
8 . The implant of claim 7 , wherein the drug elutes from the drug delivery ocular implant for a period of time ranging from about 24 to about 48 months.
9 . The implant of claim 1 , further comprising a distally-positioned seal limiting fluid communication between the at least partially enclosed space and an ocular space in which the implant is positioned to that occurring through the permeable or semi-permeable material.
10 . The implant of claim 1 , wherein the physiological outflow pathway is Schlemm's Canal.
11 . A drug delivery ocular implant comprising:
an outer shell having a proximal end and a distal end, the outer shell being shaped to define an at least partially enclosed space;
a drug positioned within the at least partially enclosed space;
a cap disposed at the proximal end of the outer shell, the cap having compressible regions configured to seal the cap to the proximal end of the outer shell;
a coating positioned between the cap and the proximal end of the outer shell, the coating being compressed by the cap; and
at least one fluid inflow pathway and one fluid outflow pathway positioned adjacent the distal end of the outer shell,
wherein the at least one fluid inflow pathway and one fluid outflow pathway are configured to deliver ocular fluid to a physiological outflow pathway.
12 . The implant of claim 11 , wherein the coating is a permeable or semi-permeable membrane.
13 . The implant of claim 11 , wherein the cap extends toward the distal end of the outer shell and encloses only a portion of the outer shell.
14 . The implant of claim 11 , further comprising a retention feature configured to anchor the implant in place.
15 . The implant of claim 11 , wherein the cap comprises at least one aperture.
16 . The implant of claim 11 , wherein the cap has compressed regions configured to seal the cap to the proximal end of the outer shell.
17 . The implant of claim 11 , wherein the physiological outflow pathway is Schlemm's Canal.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 30, 2025
From: DOSE MEDICAL CORPORATION
To: GLAUKOS CORPORATION
Reel/Frame 070066/0322 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 29, 2025
From: HAFFNER, DAVID S.; BURNS, THOMAS W.; HEITZMANN, HAROLD A.; CURRY, KENNETH M.
To: DOSE MEDICAL CORPORATION
Reel/Frame 070050/0982 →
Continuity (10)
Continuation In Part
13321144
Provisional Application
61788731
· Mar 15, 2013
Provisional Application
61264594
· Nov 25, 2009
Provisional Application
61264615
· Nov 25, 2009
Provisional Application
61264604
· Nov 25, 2009
Provisional Application
61220527
· Jun 25, 2009
Provisional Application
61179332
· May 18, 2009
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