IP Library › Granted Patent US 12,276,624
Granted Patent B2
US 12,276,624 · App. 17/829,565 · Granted Apr 15, 2025

Systems and methods for quantum sensing with signal amplification by reversible exchange

Inventors: Ronald Walsworth (Newton, MA); Nithya Arunkumar (Waltham, MA); Dominik Bucher (Puchheim, DE); Matthew Turner (Cambridge, MA); David Glenn (Cambridge, MA); Matthew S. Rosen (Somerville, MA); Thomas Theis (Durham, NC)
Assignees: University of Maryland, College Park; The President and Fellows of Harvard College; North Carolina State University
G01N24/006G01N24/08G01N33/389
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Quick Facts
Patent No.
US 12,276,624
App. No.
17/829,565
Granted
Apr 15, 2025
Kind
B2
Abstract

Systems and methods of quantum sensing include depositing a sample volume onto an ensemble of quantum defects, hyperpolarizing spins in the sample volume, performing a sensing sequence, and reading out information regarding electronic spin states of the quantum defects in the ensemble of quantum defects, which sense the hyperpolarized spins in the sample volume.

Claims (45)

1. A method of quantum sensing, comprising:

depositing a sample volume onto an ensemble of quantum defects;

hyperpolarizing spins in the sample volume;

performing a sensing sequence; and

reading out information regarding electronic spin states of the quantum defects in the ensemble of quantum defects, which sense the hyperpolarized spins in the sample volume.

2. The method according to claim 1 , further comprising preparing the sample volume by introducing a catalyst into the sample volume.

3. The method according to claim 2 , further comprising dispersing parahydrogen into the sample volume to activate the catalyst.

4. The method according to claim 3 , further comprising performing parahydrogen bubbling, wherein the parahydrogen bubbling hyperpolarizes the spins in the sample volume.

5. The method according to claim 1 , wherein hyperpolarizing the spins includes performing signal amplification by reversible exchange (SABRE).

6. The method according to claim 1 , further comprising applying a magnetic bias field to the ensemble of quantum defects.

7. The method according to claim 1 , further comprising applying a radio frequency (RF) pulse to the ensemble of quantum defects after hyperpolarizing the spins and before performing the sensing sequence.

8. The method according to claim 7 , wherein the RF pulse is π/2 RF pulse.

9. The method according to claim 7 , further comprising implementing a wait time after hyperpolarizing the spins and before applying the RF pulse.

10. The method according to claim 1 , wherein performing the sensing sequence includes performing a coherently averaged synchronized readout (CASR) sequence.

11. The method according to claim 1 , wherein reading out the information regarding electronic spin states includes reading out a population difference of the electronic spin states.

12. The method according to claim 1 , wherein the ensemble of quantum defects includes a plurality of nitrogen vacancy (NV) centers in diamond.

13. The method according to claim 1 , further comprising repeating, a plurality of times: hyperpolarizing the spins in the sample volume, performing the sensing sequence, and reading out the information regarding the electronic spin states.

14. The method according to claim 13 , further comprising implementing a wait time after reading out the information regarding the electronic spin states and before repeating hyperpolarizing the spins in the sample volume.

15. The method according to claim 1 , further comprising, after reading out the information regarding electronic spin states, re-initializing the electronic spin states of the quantum defects.

16. The method according to claim 1 , wherein re-initializing includes applying an optical re-initialization pulse to the ensemble of quantum defects.

17. A quantum sensing system, comprising:

an ensemble of quantum defects configured to receive a sample volume thereon;

a tube configured to deliver parahydrogen to the sample volume to hyperpolarize spins in the sample volume;

a laser source configured to deliver a sensing sequence of light pulses to the ensemble of quantum defects; and

a sensor configured to read out information regarding electronic spin states of the quantum defects in the ensemble of quantum defects, which sense the hyperpolarized spins in the sample volume.

18. The quantum sensing system according to claim 17 , further comprising an antenna configured to deliver radio frequency (RF) pulses to the ensemble of quantum defects.

19. The quantum sensing system according to claim 17 , wherein the ensemble of quantum defects includes a plurality of nitrogen vacancy (NV) centers in diamond.

20. The quantum sensing system according to claim 17 , further comprising a controller including at least one processor and at least one associated memory storing instructions to be executed by the at least one processor to cause the at least one controller to repeatedly:

direct the delivery of parahydrogen to the sample volume via the tube;

direct the laser source to deliver the sensing sequence of light pulses to the ensemble of quantum defects; and

obtain, from the sensor, the read out information regarding the electronic spin states of the quantum defects in the ensemble of quantum defects.

21. A method of quantum sensing, comprising:

providing an ensemble of quantum defects having a sample volume deposited on the ensemble of quantum defects, wherein spins in the sample volume are hyperpolarized; and

performing a quantum sensing protocol to read out information regarding electronic spin states of the quantum defects in the ensemble of quantum defects, which sense the hyperpolarized spins in the sample volume.

22. The method according to claim 21 , wherein the quantum sensing protocol includes a sensing sequence.

23. The method according to claim 22 , wherein the sensing sequence includes a coherently averaged synchronized readout (CASR) sequence.

24. The method according to claim 21 , wherein the quantum sensing protocol includes a read out pulse.

25. The method according to claim 24 , wherein the read out pulse reads out a population difference of the electronic spin states of the quantum defects in the ensemble of quantum defects.

26. The method according to claim 21 , wherein providing the ensemble of quantum defects having the sample volume deposited on the ensemble of quantum defects includes:

depositing the sample volume on the ensemble of quantum defects; and

hyperpolarizing the spins in the sample volume deposited on the ensemble of quantum defects.

27. The method according to claim 21 , further comprising, repeating at least once after performing the quantum sensing protocol:

hyperpolarizing the spins in the sample volume; and

performing the quantum sensing protocol again.

28. The method according to claim 27 , further comprising, for each repeat, re-initializing the electronic spin states of the quantum defects after a prior quantum sensing protocol and before a next hyperpolarizing.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 18, 2025
From: BUCHER, DOMINIK; GLENN, DAVID R.
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 070550/0792 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 18, 2025
From: THEIS, THOMAS
To: NORTH CAROLINA STATE UNIVERSITY
Reel/Frame 070550/0892 →
Continuity (3)
Provisional Application 63197309 · Jun 4, 2021
Provisional Application 63195591 · Jun 1, 2021
Related Publication 20230081886A1 · Mar 16, 2023
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