IP Library › Granted Patent US 12,226,377
Granted Patent B2
US 12,226,377 · App. 17/837,740 · Granted Feb 18, 2025

Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state

Inventors: Julien Grassot (Lyons, FR); Cendrine Grangeon (Lyons, FR); Jordan Dubow (Chicago, IL)
Assignee: Flamel Ireland Limited
A61K31/19A61K9/0053A61K9/009A61K9/0095
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Quick Facts
Patent No.
US 12,226,377
App. No.
17/837,740
Granted
Feb 18, 2025
Kind
B2
Abstract

Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.

Claims (1)

1. An oral pharmaceutical composition for the treatment of a disorder treatable with gamma-hydroxybutyrate in a human subject in need thereof, the pharmaceutical composition comprising gamma-hydroxybutyrate in a unit dose, wherein absorption of the gamma-hydroxybutyrate in the gastro-intestinal tract is not substantially changed by the presence of food.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 21, 2026
From: RTW INVESTMENTS, LP, AS COLLATERAL AGENT
To: AVADEL CNS PHARMACEUTICALS, LLC; FLAMEL IRELAND LTD.
Reel/Frame 074729/0205 →
PATENT COLLATERAL AGREEMENT Recorded Aug 1, 2023
From: AVADEL CNS PHARMACEUTICALS, LLC; FLAMEL IRELAND LTD.
To: RTW INVESTMENTS, LP
Reel/Frame 064463/0907 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2022
From: GRASSOT, JULIEN; GRANGEON, CENDRINE; DUBOW, JORDAN
To: FLAMEL IRELAND LIMITED
Reel/Frame 061106/0165 →
Continuity (4)
Continuation 16804966 · Feb 28, 2020
Provisional Application 62857008 · Jun 4, 2019
Provisional Application 62812699 · Mar 1, 2019
Related Publication 20220313635A1 · Oct 6, 2022
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