Wearable device with multimodal diagnostics
A system, device and method for automatically and remotely acquiring sensor data from a wearable patch mounted on a patient. An example device implemented as a wearable patch includes a sensor assembly comprising a plurality of sensors configured to detect a corresponding plurality of sensory modalities and generate electrical signals representing the sensory modalities. A signal converter receives the electrical signals from the plurality of sensors and converts the signals to sensor data signals comprising a data representation of at least one of the electrical signals. A communications interface communicates the sensor data signals to a sensor data processing system.
1. A wearable device for sensing information relating to subcutaneous processes in a patient, the wearable device comprising:
an adhesive patch configured to attach to a body part of the patient at a location that provides subcutaneous access to a vessel being an artery, a vein, or an arteriovenous (AV) access;
a sensor assembly mounted on the adhesive patch, the sensor assembly comprises one or more sensors and each sensor of the one or more sensors is configured to generate one or more electrical signals corresponding to a sensory modality sensed by the sensor;
wherein said one or more sensors comprise a first sensor to detect acceleration and a second sensor configured to detect sound, said first sensor and said second sensor are configured to acquire data synchronously, said first sensor provides an indication of signal quality of the second sensor;
a signal converter configured to receive the electrical signals from the one or more sensors and to convert the electrical signals to one or a plurality of sensor data signals, wherein the one or the plurality of sensor data signals comprises a data representation of at least one of the electrical signals that, when analyzed by a processor, determines stenosis of the vessel; and
a power source and a shelf sensor, wherein the shelf sensor is configured to place the wearable device into a shelf mode in which power is either disconnected from the sensor assembly or the sensor assembly is placed into a low power mode.
2. The wearable device of claim 1 , wherein the second sensor is a photo-plethysmogram (PPG) sensor that comprises at least one light source to direct light towards the vessel and at least one light detector to detect reflected light from fluid flowing through the vessel to obtain a volumetric measurement of the vessel.
3. The wearable device of claim 2 , wherein the second sensor is an electrocardiography sensor.
4. The wearable device of claim 2 , wherein the sensor assembly comprises an ultrasonic transducer and an ultrasonic sensor.
5. The wearable device of claim 2 , wherein the one or more sensors of the sensor assembly comprises an acoustic sensor having a substantially flat sensitivity less than ten kilohertz.
6. The wearable device of claim 2 , wherein the one or more sensors of the sensor assembly comprises a strain gauge having a sensitivity to a mechanical strain between about 0.1 hertz (Hz), and about 9 megahertz (Mhz).
7. The wearable device of claim 2 , wherein the one or more sensors of the sensor assembly comprises a temperature sensor having a resolution below about 0.1 degrees C.
8. The wearable device of claim 2 , wherein the one or more sensors of the sensor assembly comprises a temperature sensor, and wherein the signal converter is configured to sample electrical signals representing a temperature reading from the temperature sensor at about 8 hertz (Hz).
9. The wearable device of claim 2 , wherein the one or more sensors of the sensor assembly comprises two or more temperature sensors configured to provide a differential temperature measurement.
10. The wearable device of claim 9 , wherein a first temperature sensor is positioned within the patch to obtain a temperature reading of a first location distal to the AV access being an arteriovenous (AV) fistula and a second temperature sensor is positioned within the adhesive patch to obtain a temperature reading of a second location adjacent and distal to the AV fistula, wherein an inference of blood flow through the AV fistula is determine based on a difference between the first temperature and the second temperature.
11. The wearable device of claim 2 , wherein the AV access corresponds to an arteriovenous (AV) fistula.
12. The wearable device of claim 1 , wherein the one or more sensors of the sensor assembly comprises an acoustic sensor and an accelerometer.
13. The wearable device of claim 12 , wherein the acoustic sensor is a piezoelectric device.
14. The wearable device of claim 13 , wherein the piezoelectric device is made of one or more materials selected from the group consisting of polyvinylidene fluoride (PVDF), lead zirconate (PZT), and a composite including either PVDF or PZT materials.
15. The wearable device of claim 12 , wherein the acoustic sensor is a microphone.
16. The wearable device of claim 15 , wherein the microphone is implemented using a microelectromechanical system.
17. The wearable device of claim 15 , wherein the vessel is the AV access corresponding to an arteriovenous (AV) fistula, and wherein the microphone is configured to measure an acoustic signature of blood flow through the AV fistula.
18. The wearable device of claim 17 , wherein the adhesive patch is attached to a skin of the patient body in proximity to the AV fistula through a biocompatible adhesive having acoustic impedance.
19. The wearable device of claim 1 further comprising:
a communications interface configured to communicate the one or the plurality of sensor data signals to a sensor data processing system.
20. The wearable device of claim 19 , wherein the communications interface comprises a wireless transmitter configured to transmit the one or a plurality of sensor data signals to the sensor data processing system and the wireless transmitter is configured to communicate radio frequency signals.
21. The wearable device of claim 20 , wherein the radio frequency signals are configured to be communicated using a near field communication protocol.
22. The wearable device of claim 19 , wherein the communications interface comprises a wireless transmitter configured to transmit the one or a plurality of sensor data signals to the sensor data processing system and the wireless transmitter is configured to communicate using a cellular communications system.
23. The wearable device of claim 19 , wherein the communications interface comprises a wireless transmitter configured to communicate using a wireless local area network system or a near field magnetic communication system.
24. The wearable device of claim 1 ,
wherein the shelf mode is configured to be automatically entered based at least in a part on readings from any one or more of:
magnetic sensors or switches;
optical sensors;
motion, acceleration or tilt sensors;
temperature sensors;
capacitive proximity sensors; and
mechanical switches.
25. The wearable device of claim 1 , further comprising:
wherein the shelf mode is configured to be invoked by a microcontroller device and is configured to be exited based at least in part on readings from any one or more of:
magnetic sensors or switches;
optical sensors;
motion, acceleration, or tilt sensors;
temperature sensors;
capacitive proximity sensors; and
mechanical switches.
26. The wearable device of claim 24 or 25 , wherein the readings are based at least in part on an interaction with a product packaging or an adhesive backing liner, and wherein the shelf mode is configured to be exited when the adhesive patch is removed from the product packaging.
27. The wearable device of claim 1 , wherein the adhesive patch is configured to monitor an arteriovenous (AV) fistula being the vessel.
28. The wearable device of claim 27 , wherein each sensor of the one or more sensors of the sensor assembly is configured to monitor a condition or state of the AV fistula.
29. The wearable device of claim 1 , wherein the one or more sensors of the sensor assembly include a photo-plethysmogram (PPG) sensor that includes one or more light sources to detect reflected light from fluid flowing through the vessel.
30. The wearable device of claim 1 , further comprising a third sensor configured to at least detect optical energy.
31. The wearable device of claim 30 , further comprising a fourth sensor configured to measure electrocardiography signals.
32. A wearable device for sensing information relating to subcutaneous processes in a patient, the wearable device comprising:
an adhesive patch configured to attach to a body part of the patient at a location that provides subcutaneous access to an arteriovenous (AV) access;
a sensor assembly mounted on the adhesive patch, the sensor assembly comprises one or more sensors including a photo-plethysmogram (PPG) sensor that includes one or more light sources to detect reflected light from fluid flowing through the AV access to obtain a volumetric measurement of the vessel, the one or more sensors, including the PPG sensor, being configured to generate one or more electrical signals corresponding to a sensory modality sensed by the one or more sensors;
said one or more sensors further comprise a first sensor to detect acceleration and a second sensor configured to detect sound, said first sensor and said second sensor are configured to acquire data synchronously, said first sensor provides an indication of signal quality of the second sensor;
a signal converter configured to receive the electrical signals from the one or more sensors and to convert the electrical signals to one or a plurality of sensor data signals, wherein the one or the plurality of sensor data signals comprises a data representation of at least one of the electrical signals that, when analyzed by a processor, determines a thrombosis development or clinically actionable levels of stenosis; and
a power source and a shelf sensor, wherein the shelf sensor is configured to place the wearable device into a shelf mode in which power is either disconnected from the sensor assembly or the sensor assembly is placed into a low power mode.
33. The wearable device of claim 32 , wherein the AV access corresponds to an arteriovenous (AV) fistula.