Method for treatment of pancreatitis
A composition for preventing and/or treating pancreatitis and a method of prevention and/or treatment of pancreatitis are disclosed. The composition include an aryl ethene compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, as an active ingredient. Also disclosed is a use of the aryl ethene compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, in manufacturing a medicament for preventing and/or treating pancreatitis or for treating one or more symptoms of pancreatitis in a patient. The method of prevention and/or treatment of pancreatitis includes administering the aryl ethene compound, an isomer, a pharmaceutically acceptable salt thereof, or a solvate thereof, in an effective amount to a subject in need thereof.
1 . A method for treating pancreatitis in a subject in need thereof or for treating one or more symptoms of pancreatitis in a subject suffering from pancreatitis, said method comprising administering, to the subject, an effective amount of a compound selected from the following compounds:
a pharmaceutically acceptable salt thereof,
wherein the one or more symptoms are abdominal pain, back pain, swollen abdomen, nausea, vomiting, fever, rapid pulse, or a combination of two or more thereof.
2 . The method of claim 1 , wherein the pancreatitis is acute pancreatitis.
3 . The method of claim 1 , wherein the pancreatitis is chronic pancreatitis.
4 . The method of claim 1 , wherein the pancreatitis is hemorrhagic pancreatitis, necrotizing pancreatitis, or hemorrhagic-necrotizing pancreatitis.
5 . The method of claim 1 , wherein the subject is a mammal.
6 . The method of claim 5 , wherein the mammal is human.
7 . The method of claim 1 , wherein the compound is (E)-5-(4-hydroxyphenyl)-5-(4-(4-isopropylpiperazin-1-yl)phenyl)-4-phenylpent-4-en-1-ol of the following chemical formula:
or a pharmaceutically acceptable salt.
8 . The method of claim 1 , wherein the effective amount is 0.01 mg/kg to 1,000 mg/kg.