IP Library › Granted Patent US 50,550
Granted Patent E1
US 50,550 · App. 17/875,657 · Granted Aug 26, 2025

IL-2 muteins and uses thereof

Inventors: Nathan Higginson-Scott (Hingham, MA); Joanne L. Viney (Belmont, MA); Jyothsna Visweswaraiah (Arlington, MA); Erik Robert Sampson (Sudbury, MA); Kevin Lewis Otipoby (Ashland, MA)
Assignee: Pandion Operations, Inc.
A61K38/2013A61K39/39533A61K47/6813
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Quick Facts
Patent No.
US 50,550
App. No.
17/875,657
Granted
Aug 26, 2025
Kind
E1
Abstract

The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Claims (27)

1. A method of increasing I regulatory cell proliferation in a subject, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a peptide comprising the amino acid sequence of SEQ ID NO: 26 wherein the I regulatory cell proliferation is increased in the subject.

2. The method of claim 1 , wherein the peptide further comprises a N-terminal leader peptide having the amino acid sequence of SEQ. ID. No: 7.

3. The method of claim 1 , wherein the peptide further comprises a linker peptide at the C-terminus.

4. The method of claim 3 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4.

5. The method of claim 1 , wherein the peptide further comprises a Fc peptide.

6. The method of claim 5 , wherein the Fc peptide comprises the amino acid sequence of SEQ ID NO: 8 or SEQ ID NO: 15.

7. The method of claim 5 , wherein the peptide further comprises a leader peptide having the sequence of SEQ. ID. No: 7 at the N-terminus of the peptide.

8. The method of claim 5 , wherein the Fc peptide is at the C-terminus of the peptide.

9. The method of claim 5 , wherein the Fc peptide is at the N-terminus of the peptide.

10. The method of claim 5 , wherein the peptide further comprises a linker peptide that links the peptide of SEQ ID NO: 26 and the Fc peptide.

11. The method of claim 10 , wherein the peptide further comprises a N-terminal leader peptide having the amino acid sequence of SEQ. ID. No: 7 at the N terminus.

12. The method of claim 10 , wherein the linker peptide comprises the sequence of is (GGGGS) n , wherein n is 1, 2, 3, or 4.

13. The method of claim 10 , wherein the Fc peptide comprises the amino acid sequence of SEQ ID NO: 8 or SEQ ID NO: 15.

14. The method of claim 10 , wherein the Fc peptide is at the C-terminus of the peptide.

15. The method of claim 10 , wherein the Fc peptide is at the N-terminus of the peptide.

16. The method of claim 10 , wherein the peptide comprises the amino acid sequence of SEQ ID NO: 40 39.

17. The method of claim 1 wherein the method further comprises activating the T regulatory cells.

18. A method of activating T regulatory cells in a subject, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a peptide comprising the amino acid sequence of SEQ ID NO: 26, wherein the I regulatory cells are activated in the subject.

19. The method of claim 2 , wherein the peptide further comprises a Fc peptide.

20. The method of claim 19 , wherein the Fc peptide is at the C-terminus or the N-terminus of the peptide.

21. The method of claim 19 , wherein the peptide comprises the amino acid sequence of SEQ ID NO: 40 39.

22. The method of claim 1 , wherein the peptide further comprises a linker peptide at the N-terminus.

23. The method of claim 14 , wherein the peptide linker links the N-terminus of the Fc peptide to the C-terminus of the peptide.

24. The method of claim 15 , wherein the peptide linker links the C-terminus of the Fc peptide to the N-terminus of the peptide.

25. The method of claim 22 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4.

26. The method of claim 23 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4.

27. The method of claim 24 , wherein the linker peptide comprises the sequence of (GGGGS) n , wherein n is 1, 2, 3, or 4.

Continuity (6)
Continuation In Part 16109875 · Aug 23, 2018
Continuation In Part 16109897 · Aug 23, 2018
Provisional Application 62721644 · Aug 23, 2018
Provisional Application 62675972 · May 24, 2018
Provisional Application 62595357 · Dec 6, 2017
Reissue 16203018 · Nov 28, 2018
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