Granted Patent B2

US 12,239,301 · App. 17/930,532 · Granted Mar 4, 2025

Inventors: Lucian Mihailescu (Pleasant Hill, CA); Michael J. Quinlan (Pleasant Hill, CA); Victor Arie Negut (Berkeley, CA)

Assignee: Ziteo, Inc.

A61B17/00234A61B6/027A61B6/4057A61B6/4241A61B6/4258A61B6/466A61B6/5205A61B6/547A61B34/20A61B2034/2048A61B2034/2051A61B2034/2057A61B2034/2065A61B34/25A61B2090/306A61B2090/367A61B2090/3912A61B2090/3937

Abstract

Claims (41)

1. A radiation position sensitive apparatus, comprising:

a housing assembly having a longitudinal axis;

a gamma ray probe at least partially enclosed within the housing assembly;

a tracking camera at least partially enclosed within the housing assembly, the tracking camera having a tracking field of view, the tracking camera disposed at a predetermined proximity to the gamma ray probe;

at least one processor and a memory operatively coupled with the tracking camera, the memory having instructions for execution by the at least one processor for:

calculating a spatial position and orientation of images taken by the tracking camera with respect to an object; and

associating scanning data from the gamma ray probe with the calculated spatial position and orientation of the images to determine a position and orientation of the scanning data using the known proximity of the gamma ray probe to the tracking camera.

2. The apparatus of claim 1 , wherein the memory has instructions for execution by the at least one processor configured to convert the scanning data to a reconstructed diagram identifying a relative location of a radiation source to the object.

3. The apparatus of claim 2 , wherein the reconstructed diagram is produced using Compton imaging, self-collimation effects, or proximity imaging.

4. The apparatus of claim 2 , wherein the memory has instructions for execution by the at least one processor configured to combine the images and the reconstructed diagram to produce a three-dimensional (3-D) model of a subject's tissue.

5. The apparatus of claim 4 , further comprising:

a display screen operably linked to the at least one processor and configured to show instantaneous renderings of the 3-D model.

6. The apparatus of claim 2 , further comprising:

a display screen operably linked to the at least one processor and configured to show instantaneous renderings of the reconstructed diagram.

7. The apparatus of claim 1 , wherein the object comprises a fiducial.

8. The apparatus of claim 1 , further comprising:

a transparent optical window along a side of the housing assembly through which the tracking camera is configured to see the tracking field of view.

9. The apparatus of claim 8 , further comprising:

a device configured for supplying a stream of fluid in order to keep the transparent optical window clear.

10. The apparatus of claim 9 , wherein the stream of fluid comprises air or liquid.

11. The apparatus of claim 8 , further comprising:

an illumination source with an illumination field of view that overlaps the tracking field of view.

12. The apparatus of claim 11 , wherein the illumination source includes an optical fiber.

13. The apparatus of claim 11 , further comprising:

a transparent illumination window wherein the illumination source illuminates the tracking field of view through the transparent illumination window.

14. The apparatus of claim 11 , wherein the illumination source is selected from the group consisting of spatially patterned light, spectrally coded light, time coded light, uniform light, and combinations thereof.

15. The apparatus of claim 13 , further comprising:

a device configured for supplying a stream of fluid to keep the transparent illumination window clear.

16. The apparatus of claim 15 , wherein the stream of fluid comprises air or liquid.

17. The apparatus of claim 1 , wherein the gamma ray probe comprises an enclosed matrix surrounding a sensor.

18. The apparatus of claim 17 , wherein a material of the sensor is selected from the group consisting of a cadmium zinc tellurium (CdZnTe) detector, a position sensitive scintillator, a segmented silicon (Si) detector, a depleted charge-coupled device (CCD) sensor, and a depleted complementary metal-oxide semiconductor (CMOS) sensor.

19. The apparatus of claim 17 , wherein the sensor is a first sensor and the gamma ray probe further comprises: a second sensor proximate to the first sensor.

20. A medical navigation apparatus, comprising:

a housing assembly;

a sensor probe at least partially enclosed within the housing assembly;

a tracking camera at least partially enclosed within the housing assembly, the tracking camera pointing outward from the housing assembly, the tracking camera disposed at a predetermined position and orientation with respect to the probe;

at least one processor and a memory operatively coupled with the tracking camera, the memory having instructions for execution by the at least one processor for:

calculating a spatial position and orientation of the tracking camera with respect to an object based on an image that includes the object; and

computing a spatial position and orientation of the sensor probe; and

associating scanning data from the probe with the computed spatial position and orientation of the sensor probe.

21. The apparatus of claim 20 , wherein the sensor probe is selected from the group consisting of a magnetic sensor, an electromagnetic sensor, and a gamma ray detector.

Assignments (3)

Continuity (4)

References Cited (315)