IP Library › Granted Patent US 11,844,802
Granted Patent B2
US 11,844,802 · App. 17/936,184 · Granted Dec 19, 2023

Compounds and compositions for ossification and methods related thereto

Inventors: Scott D. Boden (Atlanta, GA); Sreedhara Sangadala (Atlanta, GA)
Assignees: Emory University; The US Govt as represented by the Dept of VA
A61K31/53A61K38/1875A61L27/54C07D251/18A61L2300/412A61L2430/02
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Quick Facts
Patent No.
US 11,844,802
App. No.
17/936,184
Granted
Dec 19, 2023
Kind
B2
Abstract

The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.

Claims (20)

1. A kit comprising 1-(4-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-1,3,5-triazine or salt thereof, and a graft matrix.

2. The kit of claim 1 , wherein the graft matrix comprises collagen.

3. The kit of claim 1 , wherein the graft matrix comprises calcium phosphates.

4. The kit of claim 1 , wherein the graft matrix comprises bioglass.

5. The kit of claim 1 , wherein the graft matrix comprises a hydrogel polymer.

6. The kit of claim 1 , wherein the kit further comprises a growth factor.

7. The kit of claim 6 , wherein the growth factor is a bone morphogenetic protein.

8. The kit of claim 7 , wherein the bone morphogenetic protein is BMP-2, BMP-7, BMP-6, or BMP-9.

9. The kit of claim 1 , wherein the kits further comprise a transfer device.

10. The kit of claim 9 , wherein the transfer device is a syringe or pipette.

11. A kit comprising 1-(4-chlorophenyl)-5-isopropyl-biguanide or salt thereof, and a graft matrix.

12. The kit of claim 11 , wherein the graft matrix comprises collagen.

13. The kit of claim 11 , wherein the graft matrix comprises calcium phosphates.

14. The kit of claim 11 , wherein the graft matrix comprises bioglass.

15. The kit of claim 11 , wherein the graft matrix comprises a hydrogel polymer.

16. The kit of claim 11 , wherein the kit further comprises a growth factor.

17. The kit of claim 16 , wherein the growth factor is a bone morphogenetic protein.

18. The kit of claim 17 , wherein the bone morphogenetic protein is BMP-2, BMP-7, BMP-6, or BMP-9.

19. The kit of claim 11 , wherein the kits further comprise a transfer device.

20. The kit of claim 19 , wherein the transfer device is a syringe or pipette.

Continuity (8)
Continuation 17122853 · Dec 15, 2020
Continuation 16732959 · Jan 2, 2020
Continuation 15801964 · Nov 2, 2017
Continuation 15334030 · Oct 25, 2016
Division 13816312
Provisional Application 61479910 · Apr 28, 2011
Provisional Application 61374667 · Aug 18, 2010
Related Publication 20230044670A1 · Feb 9, 2023