IP Library › Granted Patent US 12,465,566
Granted Patent B2
US 12,465,566 · App. 17/947,974 · Granted Nov 11, 2025

Snuff composition

Inventors: Anders Axelsson (Bjärred, SE); Arne Kristensen (Helsingborg, SE); Henri Hansson (Helsingborg, SE)
Assignee: Modoral Brands Inc.
A61K9/0056A24B13/00A24B15/14A24B15/16A61K9/009A61K31/465A61K9/146
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Quick Facts
Patent No.
US 12,465,566
App. No.
17/947,974
Granted
Nov 11, 2025
Kind
B2
Abstract

Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.

Claims (51)

1 . A product for delivery of an oral composition, the product comprising:

a composition including a cellulose material and nicotine, at least a portion of the nicotine being sorbed to at least a portion of the cellulose material so as to be in the form of a nicotine-cellulose combination and such that the nicotine-cellulose combination forms 10% to 100% by weight of a total weight of the composition; and

enclosing the composition.

2 . The product of claim 1 , wherein the nicotine-cellulose combination forms at least 45% by weight of the total weight of the composition.

3 . The product of claim 1 , wherein the nicotine-cellulose combination forms at least 80% to 98% by weight of the total weight of the composition.

4 . The product of claim 1 , wherein the nicotine is nicotine free base or a pharmaceutically acceptable salt, solvate, complex, or derivative thereof.

5 . The product of claim 1 , wherein the nicotine is in the form of a nicotine salt.

6 . The product of claim 5 , wherein the nicotine salt is nicotine bitartrate.

7 . The product of claim 1 , wherein the nicotine is present in a total amount of about 0.5 mg to about 10 mg.

8 . The product of claim 1 , wherein the composition includes a further cellulose in addition to the cellulose material.

9 . The product of claim 1 , wherein the composition includes one or more of the following:

at least one sugar alcohol;

at least one artificial sweetener;

sodium carbonate;

sodium hydrogen carbonate;

at least one flavoring.

10 . The product of claim 1 , wherein the nicotine and the cellulose material are combined such that, when subjected to an in vitro dissolution test using UV detection, about 30% or more of the total content of the nicotine is released from the composition within 30 minutes.

11 . The product of claim 1 , wherein the pouch is formed of cellulose.

12 . The product of claim 1 , wherein at least a portion of the nicotine is absorbed into at least a portion of the cellulose material.

13 . The product of claim 1 , wherein at least a portion of the nicotine is adsorbed onto at least a portion of the cellulose material.

14 . A product for delivery of an oral composition, the product comprising:

(a) a composition that includes:

a cellulose material; and

nicotine that is one or both of absorbed into and adsorbed onto at least a portion of the cellulose material so as to be in the form a nicotine-cellulose combination that forms 10% to 100% by weight of the total weight of the composition; and

(b) a pouch enclosing the composition.

15 . The product of claim 14 , wherein the nicotine is nicotine free base or a pharmaceutically acceptable salt, solvate, complex, or derivative thereof.

16 . The product of claim 14 , wherein the nicotine is in the form of a nicotine salt.

17 . The product of claim 16 , wherein the nicotine salt is nicotine bitartrate.

18 . The product of claim 14 , wherein the nicotine is present in a total amount of about 0.5 mg to about 10 mg.

19 . The product of claim 14 , wherein the composition includes a further cellulose in addition to the cellulose material.

20 . The product of claim 14 , wherein the composition includes one or more of the following:

at least one sugar alcohol;

at least one artificial sweetener;

sodium carbonate;

sodium hydrogen carbonate;

at least one flavoring.

21 . The product of claim 14 , wherein the nicotine and the cellulose material are combined such that, when subjected to an in vitro dissolution test using UV detection, about 30% or more of the total content of the nicotine is released from the composition within 30 minutes.

22 . The product of claim 14 , wherein the pouch is formed of cellulose.

23 . A product for delivery of an oral composition, the product comprising:

(a) a composition that includes:

a cellulose material;

nicotine that is sorbed to at least a portion of the cellulose material so as to be in the form a nicotine-cellulose combination that forms at least 10% by weight of the total weight of the composition;

one or more of: at least one sugar alcohol; at least one artificial sweetener; sodium carbonate; sodium hydrogen carbonate; at least one flavoring; and

(b) a pouch enclosing the composition.

24 . The product of claim 23 , wherein the nicotine is nicotine free base or a pharmaceutically acceptable salt, solvate, complex, or derivative thereof.

25 . The product of claim 23 , wherein the nicotine is in the form of a nicotine salt.

26 . The product of claim 25 , wherein the nicotine salt is nicotine bitartrate.

27 . The product of claim 23 , wherein the nicotine is present in a total amount of about 0.5 mg to about 10 mg.

28 . The product of claim 23 , wherein the composition includes a further cellulose in addition to the cellulose material.

29 . The product of claim 23 , wherein the nicotine and the cellulose material are combined such that, when subjected to an in vitro dissolution test using UV detection, about 30% or more of the total content of the nicotine is released from the composition within 30 minutes.

30 . The product of claim 23 , wherein the pouch is formed of cellulose.

Priority Claims (2)
DK 2006 00375 · Mar 16, 2006 · national
DK 2006 00376 · Mar 16, 2006 · national
Continuity (7)
Continuation 17458997 · Aug 27, 2021
Continuation 16194969 · Nov 19, 2018
Continuation 13690531 · Nov 30, 2012
Continuation 12225262
Provisional Application 60782903 · Mar 16, 2006
Provisional Application 60782977 · Mar 16, 2006
Related Publication 20230009314A1 · Jan 12, 2023
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