IP Library › Granted Patent US 12,377,189
Granted Patent B2
US 12,377,189 · App. 17/979,168 · Granted Aug 5, 2025

Osteoinductive bone implant including harvested demineralized bone and bone morphogenetic proteins bound thereto obtained from the same donor

Inventor: Amit Prakash Govil (Irvine, CA)
Assignee: Bioventus LLC
A61L27/227A61F2/28A61F2/4644A61K35/32A61L27/20A61L27/3608A61L27/365A61L27/3687A61L27/3691A61L27/46A61L27/54A61L27/56A61F2002/2817A61F2002/4646A61L2300/414A61L2300/64A61L2400/16A61L2430/02A61L2430/40
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Quick Facts
Patent No.
US 12,377,189
App. No.
17/979,168
Granted
Aug 5, 2025
Kind
B2
Abstract

Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.

Claims (8)

1. A bone implant comprising:

demineralized bone harvested from a donor; and

bone morphogenetic proteins obtained by release and solubilization from one or more of cellular material, bone marrow, and blood, each from the same donor as the harvested bone;

wherein the bone morphogenetic proteins are bound to the demineralized bone after release and solubilization.

2. The bone implant of claim 1 , wherein the harvested demineralized bone comprises bone marrow.

3. The bone implant of claim 1 , wherein the harvested demineralized bone comprises cortical or cancellous bone.

4. The bone implant of claim 1 , wherein the harvested demineralized bone comprises ground particulate.

5. The bone implant of claim 1 , wherein the implant further comprises antibiotics.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2024
From: GOVIL, AMIT PRAKASH
To: ADVANCED BIOLOGICS, LLC
Reel/Frame 068069/0421 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2024
From: ADVANCED BIOLOGICS LLC
To: BIOVENTUS LLC
Reel/Frame 068069/0425 →
Continuity (6)
Continuation 16459778 · Jul 2, 2019
Continuation 15016072 · Feb 4, 2016
Continuation 12636751 · Dec 13, 2009
Provisional Application 61240283 · Sep 7, 2009
Provisional Application 61201612 · Dec 13, 2008
Related Publication 20230057820A1 · Feb 23, 2023
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