IP Library › Granted Patent US 12,208,081
Granted Patent B2
US 12,208,081 · App. 18/073,632 · Granted Jan 28, 2025

Tannin-containing gastrointestinal formulations and methods of use

Inventors: Jess Dreher Reed (Madison, WI); Dhanansayan Shanmuganayagam (Madison, WI); Christian Gerald Krueger (Cambridge, WI); Kenneth Allan Kudsk (Madison, WI); Joseph Francis Pierre (Chicago, IL); Aaron F. Heneghan (Middleton, WI); Rodrigo P. Feliciano (Düsseldorf, DE)
Assignee: Wisconsin Alumni Research Foundation
A61K31/353A23L33/10A23L33/115A23L33/17A23L33/40A61K9/0029A23V2002/00
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Quick Facts
Patent No.
US 12,208,081
App. No.
18/073,632
Granted
Jan 28, 2025
Kind
B2
Abstract

Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.

Claims (39)

1. An enteral or parenteral nutrition composition, comprising:

one or more nutrients comprising:

amino acids and/or polypeptides in an amount of at least 16% of total calories in the composition; and

carbohydrates in an amount of at least 25% of total calories in the composition; and

proanthocyanidins from one or more sources selected from the group consisting of cranberries, blueberries, grapes, sorghum, pomegranates, and pine,

wherein:

the composition is in the form of a powder and comprises the proanthocyanidins in an amount of at least 0.1 wt %, or the composition is in the form of a liquid and comprises the proanthocyanidins in an amount of at least 0.1 mg/L.

2. The composition of claim 1 , wherein the composition comprises the proanthocyanidins in an amount effective to attenuate deleterious effects of an otherwise identical composition lacking the proanthocyanidins on intestinal barrier function when administered to a patient enterally or parenterally.

3. The composition of claim 1 , wherein the amino acids and/or polypeptides are included in the composition in an amount of at least 17% of total calories in the composition.

4. The composition of claim 1 , wherein the amino acids and/or polypeptides are included in the composition in an amount of at least 20% of total calories in the composition.

5. The composition of claim 1 , wherein the amino acids and/or polypeptides are included in the composition in an amount of 17-25% of total calories in the composition.

6. The composition of claim 1 , wherein the amino acids and/or polypeptides comprise hydrolyzed protein.

7. The composition of claim 1 , wherein the amino acids and/or polypeptides comprise amino acids.

8. The composition of claim 7 , wherein the composition is devoid of polypeptides.

9. The composition of claim 1 , wherein the carbohydrates are included in the composition in an amount of at least 30% of total calories in the composition.

10. The composition of claim 1 , wherein the carbohydrates are included in the composition in an amount of 25-48% of total calories in the composition.

11. The composition of claim 1 , wherein the carbohydrates comprise monosaccharides and/or disaccharides.

12. The composition of claim 1 , wherein:

the amino acids and/or polypeptides are included in the composition in an amount of at least 20% of total calories in the composition; and

the carbohydrates are included in the composition in an amount of at least 30% of total calories in the composition.

13. The composition of claim 1 , wherein:

the amino acids and/or polypeptides are included in the composition in an amount of 17-25% of total calories in the composition; and

the carbohydrates are included in the composition in an amount of 25-48% of total calories in the composition.

14. The composition of claim 1 , wherein the one or more nutrients further comprise fatty acids and/or fatty acid esters.

15. The composition of claim 14 , wherein the fatty acids and/or fatty acid esters are included in the composition in an amount of at least 30% of total calories in the composition.

16. The composition of claim 14 , wherein the fatty acids and/or fatty acid esters are included in the composition in an amount of 35-50% of total calories in the composition.

17. The composition of claim 14 , wherein the fatty acids and/or fatty acid esters comprise medium chain triglycerides.

18. The composition of claim 14 , wherein:

the amino acids and/or polypeptides are included in the composition in an amount of at least 20% of total calories in the composition;

the carbohydrates are included in the composition in an amount of at least 30% of total calories in the composition; and

the fatty acids and/or fatty acid esters are included in the composition in an amount of at least 30% of total calories in the composition.

19. The composition of claim 18 , wherein the proanthocyanidins comprise cranberry proanthocyanidins.

20. The composition of claim 14 , wherein:

the amino acids and/or polypeptides are included in the composition in an amount of 17-25% of total calories in the composition;

the carbohydrates are included in the composition in an amount of 25-48% of total calories in the composition; and

the fatty acids and/or fatty acid esters are included in the composition in an amount of 35-50% of total calories in the composition.

21. The composition of claim 20 , wherein the proanthocyanidins comprise cranberry proanthocyanidins.

22. The composition of claim 1 , wherein the proanthocyanidins comprise cranberry proanthocyanidins.

23. A method of preparing the enteral or parenteral nutrition composition of claim 1 , the method comprising adding the proanthocyanidins to the one or more nutrients.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 2, 2022
From: REED, JESS; HENEGHAN, AARON; SHANMUGANAYAGAM, DHANANSAYAN; KRUEGER, CHRISTIAN; FELICIANO, RODRIGO; KUDSK, KENNETH; PIERRE, JOSEPH
To: WISCONSIN ALUMNI RESEARCH FOUNDATION
Reel/Frame 061953/0087 →
Continuity (6)
Continuation 17111948 · Dec 4, 2020
Continuation 16102844 · Aug 14, 2018
Continuation 15347204 · Nov 9, 2016
Continuation 14152267 · Jan 10, 2014
Provisional Application 61751647 · Jan 11, 2013
Related Publication 20230114648A1 · Apr 13, 2023
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