Neurosteroid compounds and methods for their preparation and use in treating central nervous system disorders
Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily synthesized and have improved pharmaceutical properties, including water solubility, compared to known neurosteroids.
1 . A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
3 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
4 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
5 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
6 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
7 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
8 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
9 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
10 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
11 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof; or the compound is:
or a pharmaceutically acceptable salt thereof.
12 . A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
13 . The pharmaceutical composition of claim 12 , wherein said pharmaceutically acceptable carrier is a cream, gel, liposome, nanoparticle, ointment, polymeric micelle, protein, or a microsphere.