Neurosteroid compounds and methods for their preparation and use in treating central nervous system disorders
Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily synthesized and have improved pharmaceutical properties, including water solubility, compared to known neurosteroids.
1. A method for treating epilepsy comprising administering to a subject in need thereof a therapeutically effective amount of a compound, a pharmaceutically acceptable salt of said compound, or a pharmaceutical composition comprising a pharmaceutically acceptable excipient and said compound, said compound or said pharmaceutically acceptable salt being selected from:
2. The method of claim 1 , wherein the compound is administered to a patient by oral, parenteral, intravenous, transdermal, inhalation, intracerebral or topical administration in a suitable formulation.
3. A method for treating epilepsy comprising administering to a subject in need thereof a therapeutically effective amount of a compound, a pharmaceutically acceptable salt of said compound, or a pharmaceutical composition comprising a pharmaceutically acceptable excipient and said compound, said compound or pharmaceutically acceptable salt being selected from:
4. The method of claim 3 , wherein the compound is given to a patient by oral, parenteral, intravenous, transdermal, inhalation, intracerebral or topical administration in a suitable formulation.
5. The method of claim 1 , wherein said compound or said pharmaceutically acceptable salt is
6. The method of claim 1 , wherein said compound or said pharmaceutically acceptable salt is
7. The method of claim 1 , wherein said compound or said pharmaceutically acceptable salt is
8. The method of claim 1 , wherein said compound or said pharmaceutically acceptable salt is
9. The method of claim 1 , wherein said compound or said pharmaceutically acceptable salt is
10. The method of claim 1 , wherein said compound or said pharmaceutically acceptable salt is
11. The method of claim 1 , wherein said compound or said pharmaceutically acceptable salt is
12. The method of claim 3 , wherein said compound or said pharmaceutically acceptable salt is
13. The method of claim 3 , wherein said compound or said pharmaceutically acceptable salt is
14. The method of claim 3 , wherein said compound or said pharmaceutically acceptable salt is
15. The method of claim 3 , wherein said compound or said pharmaceutically acceptable salt is
16. The method of claim 3 , wherein said compound or said pharmaceutically acceptable salt is