Biodegradable bone glue
The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.
1. A method for filling void spaces within biological tissues comprising administering an amount of the composition comprising:
a bioresorbable polymer of Formula I, or a mixture thereof;
a solvent; and
a non-solvent
to the void spaces within biological tissues; and wherein Formula I is:
wherein:
R is:
2 TEA; or
wherein:
m is between 4 and 90;
n is between 5 and 200;
x is between 1 and 200; and
y is between 0 and 200.
2. A method for filling void spaces within biological tissues in oral cavities comprising administering an amount of a composition comprising:
a bioresorbable polymer of Formula I, or a mixture thereof;
a solvent; and
a non-solvent
to the void spaces within biological tissues in oral cavities; and wherein Formula I is:
wherein:
R is:
2 TEA; or
wherein:
m is between 4 and 90;
n is between 5 and 200;
x is between 1 and 200; and
y is between 0 and 200.