IP Library Granted Patent US 12,251,393
Granted Patent B2
US 12,251,393 · App. 18/140,460 · Granted Mar 18, 2025

Compositions containing adenosine triphosphate (ATP) and methods of use

Inventors: John Rathmacher (Story City, IA); Lisa Pitchford (Ames, IA); Shawn Baier (Polk City, IA); Larry Kolb (Missoula, MT); Naji Abumrad (Nashville, TN); Matthew Legge (Bannockburn, AU)
Assignee: TSI Group Co., Ltd.
A61K31/7076A23L33/125A23L33/15A23L33/175A23L33/18A23L33/30
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Quick Facts
Patent No.
US 12,251,393
App. No.
18/140,460
Granted
Mar 18, 2025
Kind
B2
Abstract

The present invention provides a composition comprising adenosine or adenosine triphosphate (ATP) acting as an absorption enhancer when combined with a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug. Methods of administering ATP or adenosine to improve the bioavailability of a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug are described.

Claims (27)

1. A method for increasing the bioavailability of a nutritional material in an animal comprising:

administering to the animal:

at least one nutritional material;

an effective amount of β-hydroxy-β-methylbutyric acid (HMB) as an additional nutritional material; and

an absorption enhancer,

wherein the absorption enhancer that increases absorption of the at least one nutritional material is adenosine triphosphate (ATP) or adenosine.

2. The method of claim 1 , wherein the nutritional material is nutrients, proteins, peptides, vitamins, or amino acids.

3. A method for improving the absorption of a nutritional material in a human, comprising:

administering to the human:

an absorption enhancer that increases absorption of at least one nutritional material;

the at least one nutritional material; and

an effective amount of β-hydroxy-β-methylbutyric acid (HMB) as an additional nutritional material,

wherein the absorption enhancer is adenosine triphosphate (ATP) or adenosine.

4. The method of claim 3 , wherein the nutritional material is nutrients, proteins, peptides, vitamins, or amino acids.

5. The method of claim 4 , wherein the nutritional material is amino acids.

6. The method of claim 5 , wherein the amino acids are essential amino acids.

7. The method of claim 5 , wherein the amino acids are branched chain amino acids.

8. The method of claim 1 , wherein absorption enhancer is administered in a dose in the range of about 10 milligrams to about 80 grams.

9. The method of claim 1 , wherein absorption enhancer is administered in a dose in the range of about 100 milligrams to about 1.6 grams.

10. The method of claim 1 , wherein the administration is performed to administer a single dose.

11. The method of claim 1 , wherein the administration is divided to administer multiple doses over time.

12. The method of claim 4 , wherein the nutritional material is a vitamin.

13. The method of claim 1 , wherein the at least one nutritional material, the effective amount of HMB, and the absorption enhancer are administered as a dietary supplement.

14. The method of claim 1 , wherein the at least one nutritional material, the effective amount of HMB, and the absorption enhancer are administered as a foodstuff.

15. The method of claim 3 , wherein the absorption enhancer is administered in a dose in the range of about 10 milligrams to about 80 grams.

16. The method of claim 3 , wherein the absorption enhancer is administered in a dose in the range of about 100 milligrams to about 1.6 grams.

17. The method of claim 3 , wherein the administration is performed to administer a single dose.

Assignments (4)
CHANGE OF NAME Recorded Dec 3, 2024
From: JIANGYIN TSI PHARMACEUTICAL CO., LTD.
To: TSI GROUP CO., LTD.
Reel/Frame 069479/0536 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2024
From: LEGGE, MATTHEW
To: JIANGYIN TSI PHARMACEUTICAL CO., LTD.
Reel/Frame 069308/0217 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2024
From: RATHMACHER, JOHN; PITCHFORD, LISA; BAIER, SHAWN; ABUMRAD, NAJI
To: JIANGYIN TSI PHARMACEUTICAL CO., LTD.
Reel/Frame 069379/0985 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2024
From: KOLB, LARRY
To: JIANGYIN TSI PHARMACEUTICAL CO., LTD.
Reel/Frame 069379/0992 →
Continuity (4)
Continuation 17012591 · Sep 4, 2020
Provisional Application 62939986 · Nov 25, 2019
Provisional Application 62896335 · Sep 5, 2019
Related Publication 20230338408A1 · Oct 26, 2023
References Cited (15)
US 4994442A · Gil et al. · 1991 [cited by applicant]
US 6566371B2 · Jackson · 2003 [cited by applicant]
US 7585850B2 · Gorny · 2009 [cited by applicant]
US 7629329B2 · Lee · 2009 [cited by examiner]
US 8703719B1 · Abraham et al. · 2014 [cited by applicant]
US 11666593B2 · Rathmacher · 2023 [cited by examiner]
US 20050261238A1 · Lee et al. · 2005 [cited by applicant]
US 20110288012A1 · Somekawa et al. · 2011 [cited by applicant]
US 20110305737A1 · Alexiades-Armenakas · 2011 [cited by applicant]
Anonymous , “MINTEL”, Database GNPG (Online); Raspberry Flavour Maximum Pre-Workout food Supplement, Jun. 7, 2018. [cited by applicant]
Anonymous , “MINTEL”, Database Gnpd (Online); “Pre-Workout Boost”, Sep. 7, 2018. [cited by applicant]
Lowery, Ryan P., et al., “Interaction of Beta-Hydroxy-Beta-Methylbutyrate Free Acid and Adenosine Triphosphate on Muscle Mass, Strength, and Power in Resistance Trained Individuals”, Journal of Strength and Conditioning… [cited by applicant]
Wikipedia , “Branched-chain amino acid”, Nov. 25, 2018. [cited by applicant]
“ATP”, Presentation at the conference of The Japanese Society for the Study of Xenobiotics, 2003. [cited by applicant]
“ATP 20mg [AFP]”, QLifePro (instruction for package inserts of prescription drug “AFP and AFP”), Mar. 1, 2019. [cited by applicant]