IP Library Granted Patent US 11,981,685
Granted Patent B2
US 11,981,685 · App. 18/141,008 · Granted May 14, 2024

Bicyclic heterocyclyl derivatives as IRAK4 inhibitors

Inventors: Venkateshwar Rao Gummadi (Bangalore, IN); Susanta Samajdar (Bangalore, IN)
Assignee: Aurigene Oncology Limited
C07D513/04C07D498/04C07D519/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,981,685
App. No.
18/141,008
Granted
May 14, 2024
Kind
B2
Abstract

The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X 1 , X 2 , X 3 , R 1 , R 3 , ‘m’, ‘n’ and ‘p’ have the meanings given in the specification and pharmaceutically acceptable salts or stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical compositions comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Claims (6)

1. A compound selected from

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is

3. The compound of claim 1 , wherein the compound is a pharmaceutically acceptable salt of

4. The compound of claim 1 , wherein the compound is

5. The compound of claim 1 , wherein the compound is a pharmaceutically acceptable salt of

Assignments (2)
CHANGE OF NAME Recorded May 9, 2023
From: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
To: AURIGENE ONCOLOGY LIMITED
Reel/Frame 063582/0259 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 9, 2023
From: GUMMADI, VENKATESHWAR RAO; SAMAJDAR, SUSANTA
To: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Reel/Frame 063588/0185 →
Priority Claims (2)
IN 158/CHE/2014 · Jan 13, 2014 · national
IN 3000/CHE/2014 · Jun 20, 2014 · national
Continuity (6)
Continuation 17245611 · Apr 30, 2021
Continuation 16795394 · Feb 19, 2020
Continuation 16054512 · Aug 3, 2018
Continuation 15667173 · Aug 2, 2017
Continuation 15111000
Related Publication 20230331740A1 · Oct 19, 2023
Cited By (1)
US 12,410,193